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The isatin-Schiff base copper(II) complex Cu(isaepy)2 acts as delocalized lipophilic cation, yields widespread mitochondrial oxidative damage and induces AMP-activated protein kinase-dependent apoptosis.
Carcinogenesis. 2009 Jul;30(7):1115-24. doi: 10.1093/carcin/bgp105. Epub 2009 Apr 30.
Carcinogenesis. 2009.
PMID: 19406932
Free PMC article.
Carcinoma cells activate AMP-activated protein kinase-dependent autophagy as survival response to kaempferol-mediated energetic impairment.
Filomeni G, Desideri E, Cardaci S, Graziani I, Piccirillo S, Rotilio G, Ciriolo MR.
Filomeni G, et al. Among authors: graziani i.
Autophagy. 2010 Feb;6(2):202-16. doi: 10.4161/auto.6.2.10971. Epub 2010 Feb 17.
Autophagy. 2010.
PMID: 20083895
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Neuroprotection of kaempferol by autophagy in models of rotenone-mediated acute toxicity: possible implications for Parkinson's disease.
Filomeni G, Graziani I, De Zio D, Dini L, Centonze D, Rotilio G, Ciriolo MR.
Filomeni G, et al. Among authors: graziani i.
Neurobiol Aging. 2012 Apr;33(4):767-85. doi: 10.1016/j.neurobiolaging.2010.05.021. Epub 2010 Jul 1.
Neurobiol Aging. 2012.
PMID: 20594614
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Complex I and cytochrome c are molecular targets of flavonoids that inhibit hydrogen peroxide production by mitochondria.
Lagoa R, Graziani I, Lopez-Sanchez C, Garcia-Martinez V, Gutierrez-Merino C.
Lagoa R, et al. Among authors: graziani i.
Biochim Biophys Acta. 2011 Dec;1807(12):1562-72. doi: 10.1016/j.bbabio.2011.09.022. Epub 2011 Oct 12.
Biochim Biophys Acta. 2011.
PMID: 22015496
Free article.
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Double-strand DNA cleavage induced by oxindole-Schiff base copper(II) complexes with potential antitumor activity.
da Silveira VC, Luz JS, Oliveira CC, Graziani I, Ciriolo MR, da Costa Ferreira AM.
da Silveira VC, et al. Among authors: graziani i.
J Inorg Biochem. 2008 May-Jun;102(5-6):1090-103. doi: 10.1016/j.jinorgbio.2007.12.033. Epub 2008 Jan 12.
J Inorg Biochem. 2008.
PMID: 18295339
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