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Targeted Therapies for Pancreatic Cancer and Hurdles Ahead.
Aslan M, Shahbazi R, Ulubayram K, Ozpolat B. Aslan M, et al. Anticancer Res. 2018 Dec;38(12):6591-6606. doi: 10.21873/anticanres.13026. Anticancer Res. 2018. PMID: 30504367 Review.
In addition, tumor stroma represents an important biological barrier for drug delivery and successful treatment of PDAC. Small interfering RNA (siRNA) has recently emerged as a potential and targeted therapeutic approach which is now evaluated in clini …
In addition, tumor stroma represents an important biological barrier for drug delivery and successful treatment of PDAC. Small int …
Chitosan Nanoparticles for miRNA Delivery.
Denizli M, Aslan B, Mangala LS, Jiang D, Rodriguez-Aguayo C, Lopez-Berestein G, Sood AK. Denizli M, et al. Methods Mol Biol. 2017;1632:219-230. doi: 10.1007/978-1-4939-7138-1_14. Methods Mol Biol. 2017. PMID: 28730442 Free PMC article.
RNA interference techniques represent a promising strategy for therapeutic applications. In addition to small interfering RNA-based approaches, which have been widely studied and translated into clinical investigations, microRNA-based approaches are at …
RNA interference techniques represent a promising strategy for therapeutic applications. In addition to small interfering …
The ZNF304-integrin axis protects against anoikis in cancer.
Aslan B, Monroig P, Hsu MC, Pena GA, Rodriguez-Aguayo C, Gonzalez-Villasana V, Rupaimoole R, Nagaraja AS, Mangala S, Han HD, Yuca E, Wu SY, Ivan C, Moss TJ, Ram PT, Wang H, Gol-Chambers A, Ozkayar O, Kanlikilicer P, Fuentes-Mattei E, Kahraman N, Pradeep S, Ozpolat B, Tucker S, Hung MC, Baggerly K, Bartholomeusz G, Calin G, Sood AK, Lopez-Berestein G. Aslan B, et al. Nat Commun. 2015 Jun 17;6:7351. doi: 10.1038/ncomms8351. Nat Commun. 2015. PMID: 26081979 Free PMC article.
ZNF304 transcriptionally regulates beta1 integrin, which subsequently regulates Src/focal adhesion kinase and paxillin and prevents anoikis. In vivo delivery of ZNF304 siRNA by a dual assembly nanoparticle leads to sustained gene silencing for 14 days, increased anoikis an …
ZNF304 transcriptionally regulates beta1 integrin, which subsequently regulates Src/focal adhesion kinase and paxillin and prevents anoikis. …
PTGER3 induces ovary tumorigenesis and confers resistance to cisplatin therapy through up-regulation Ras-MAPK/Erk-ETS1-ELK1/CFTR1 axis.
Rodriguez-Aguayo C, Bayraktar E, Ivan C, Aslan B, Mai J, He G, Mangala LS, Jiang D, Nagaraja AS, Ozpolat B, Chavez-Reyes A, Ferrari M, Mitra R, Siddik ZH, Shen H, Yang X, Sood AK, Lopez-Berestein G. Rodriguez-Aguayo C, et al. EBioMedicine. 2019 Feb;40:290-304. doi: 10.1016/j.ebiom.2018.11.045. Epub 2019 Jan 14. EBioMedicine. 2019. PMID: 30655206 Free PMC article.
PTGER3 mRNA and protein levels were higher in cisplatin-resistant ovarian cancer cells than in their cisplatin-sensitive counterparts. FINDINGS: Silencing of PTGER3 via siRNA in cancer cells was associated with decreased cell growth and less invasiveness, as well as cell-c …
PTGER3 mRNA and protein levels were higher in cisplatin-resistant ovarian cancer cells than in their cisplatin-sensitive counterparts. FINDI …
Enhancing chemotherapy response with sustained EphA2 silencing using multistage vector delivery.
Shen H, Rodriguez-Aguayo C, Xu R, Gonzalez-Villasana V, Mai J, Huang Y, Zhang G, Guo X, Bai L, Qin G, Deng X, Li Q, Erm DR, Aslan B, Liu X, Sakamoto J, Chavez-Reyes A, Han HD, Sood AK, Ferrari M, Lopez-Berestein G. Shen H, et al. Clin Cancer Res. 2013 Apr 1;19(7):1806-15. doi: 10.1158/1078-0432.CCR-12-2764. Epub 2013 Feb 5. Clin Cancer Res. 2013. PMID: 23386691 Free PMC article.
PURPOSE: RNA interference has the potential to specifically knockdown the expression of target genes and thereby transform cancer therapy. ...EXPERIMENTAL DESIGN: Tumor accumulation of MSV/EphA2 and sustained release of siRNA from MSV were analyzed after intravenous …
PURPOSE: RNA interference has the potential to specifically knockdown the expression of target genes and thereby transform cancer the …
MicroRNA-626 inhibits mTOR pathways activity of retinal pigment epithelial cells by targeting SLC7A5 in human ARPE-19 Cells.
Ercan Ç, Elbay A, Aslan ES, Akbaş F, Ozdemir H, Ozgentürk NO. Ercan Ç, et al. Cell Mol Biol (Noisy-le-grand). 2023 Oct 31;69(10):17-22. doi: 10.14715/cmb/2023.69.10.3. Cell Mol Biol (Noisy-le-grand). 2023. PMID: 37953589
We knocked down mir-626 levels and overexpression by mir-626-siRNA transfection of human RPE cell lines, and using an MTT assay, we assessed the role of SLC7A5 on RPE cell proliferation. ...The findings demonstrate that mir-626 inhibits SLC7A5 gene expression and prolifera …
We knocked down mir-626 levels and overexpression by mir-626-siRNA transfection of human RPE cell lines, and using an MTT assay, we a …