Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1987 1
1992 1
1997 1
2001 2
2003 2
2004 2
2005 3
2006 4
2007 2
2008 5
2009 5
2010 2
2011 3
2012 2
2013 1
2014 4
2015 5
2016 1
2017 4
2018 2
2019 6
2020 6
2021 11
2022 5
2023 8
2024 2

Text availability

Article attribute

Article type

Publication date

Search Results

79 results

Results by year

Filters applied: . Clear all
Page 1
Counteracting chromatin effects of a splicing-correcting antisense oligonucleotide improves its therapeutic efficacy in spinal muscular atrophy.
Marasco LE, Dujardin G, Sousa-Luís R, Liu YH, Stigliano JN, Nomakuchi T, Proudfoot NJ, Krainer AR, Kornblihtt AR. Marasco LE, et al. Cell. 2022 Jun 9;185(12):2057-2070.e15. doi: 10.1016/j.cell.2022.04.031. Cell. 2022. PMID: 35688133 Free PMC article.
Spinal muscular atrophy (SMA) is a motor-neuron disease caused by mutations of the SMN1 gene. The human paralog SMN2, whose exon 7 (E7) is predominantly skipped, cannot compensate for the lack of SMN1. Nusinersen is an antisense oligonucleotide (ASO) that upregulates E7 in …
Spinal muscular atrophy (SMA) is a motor-neuron disease caused by mutations of the SMN1 gene. The human paralog SMN2, whose exon 7 (E7) is p …
Impact of the addition of carboplatin and/or bevacizumab to neoadjuvant once-per-week paclitaxel followed by dose-dense doxorubicin and cyclophosphamide on pathologic complete response rates in stage II to III triple-negative breast cancer: CALGB 40603 (Alliance).
Sikov WM, Berry DA, Perou CM, Singh B, Cirrincione CT, Tolaney SM, Kuzma CS, Pluard TJ, Somlo G, Port ER, Golshan M, Bellon JR, Collyar D, Hahn OM, Carey LA, Hudis CA, Winer EP. Sikov WM, et al. J Clin Oncol. 2015 Jan 1;33(1):13-21. doi: 10.1200/JCO.2014.57.0572. Epub 2014 Aug 4. J Clin Oncol. 2015. PMID: 25092775 Free PMC article. Clinical Trial.
RESULTS: Patients assigned to either carboplatin or bevacizumab were less likely to complete wP and ddAC without skipped doses, dose modification, or early discontinuation resulting from toxicity. ...
RESULTS: Patients assigned to either carboplatin or bevacizumab were less likely to complete wP and ddAC without skipped doses, dose …
Exon Skipping Is Correlated with Exon Circularization.
Kelly S, Greenman C, Cook PR, Papantonis A. Kelly S, et al. J Mol Biol. 2015 Jul 31;427(15):2414-2417. doi: 10.1016/j.jmb.2015.02.018. Epub 2015 Feb 26. J Mol Biol. 2015. PMID: 25728652
We find that circularization of exons is widespread and correlates with exon skipping, a feature that adds considerably to the regulatory complexity of the human transcriptome....
We find that circularization of exons is widespread and correlates with exon skipping, a feature that adds considerably to the regula …
Charcot's motor brain map and 19th-century neurosurgery.
Leblanc R. Leblanc R. J Neurosurg. 2021 Apr 2;135(6):1843-1848. doi: 10.3171/2020.10.JNS202651. J Neurosurg. 2021. PMID: 33799300
When the topic is broached in its historiography, it begins with Fritch and Hitzig's report on the localization of motor function in the cortex of the dog and skips rapidly to Wilder Penfield's homunculus. In that gap are found the origins of modern neurosurgery in 3 paper …
When the topic is broached in its historiography, it begins with Fritch and Hitzig's report on the localization of motor function in the cor …
Programmed Cell Death Protein 1 Inhibitors and MET Targeted Therapies in NSCLC With MET Exon 14 Skipping Mutations: Efficacy and Toxicity as Sequential Therapies.
Lau SCM, Perdrizet K, Fung AS, Mata DGMM, Weiss J, Holzapfel N, Liu G, Bradbury PA, Shepherd FA, Sacher AG, Feilotter H, Sheffield B, Hwang D, Tsao MS, Cheng S, Cheema P, Leighl NB. Lau SCM, et al. JTO Clin Res Rep. 2023 Aug 19;4(10):100562. doi: 10.1016/j.jtocrr.2023.100562. eCollection 2023 Oct. JTO Clin Res Rep. 2023. PMID: 37744308 Free PMC article.
INTRODUCTION: NSCLC with MET exon 14 skipping mutation (METex14) is associated with poor outcomes. Integration of novel targeted therapies is challenging because of barriers in testing and drug access. ...PD-1 inhibitors seem effective as an initial treatment, although gre …
INTRODUCTION: NSCLC with MET exon 14 skipping mutation (METex14) is associated with poor outcomes. Integration of novel targeted ther …
Recent advances in Duchenne muscular dystrophy.
Perkins KJ, Davies KE. Perkins KJ, et al. Degener Neurol Neuromuscul Dis. 2012 Oct 11;2:141-164. doi: 10.2147/DNND.S26637. eCollection 2012. Degener Neurol Neuromuscul Dis. 2012. PMID: 30890885 Free PMC article. Review.
In particular, RNA-based modifying approaches such as exon skipping enable expression of a shorter but functional dystrophin protein and rapid progress toward clinical application. ...
In particular, RNA-based modifying approaches such as exon skipping enable expression of a shorter but functional dystrophin protein …
Maternal and best friends' influences on meal-skipping behaviours.
Pearson N, Williams L, Crawford D, Ball K. Pearson N, et al. Br J Nutr. 2012 Sep;108(5):932-8. doi: 10.1017/S000711451100612X. Epub 2012 Jan 31. Br J Nutr. 2012. PMID: 22289518
Understanding the correlates of meal-skipping behaviours is important for the design of nutrition interventions. ...Best friend and maternal factors were differentially associated with meal-skipping behaviours. For example, boys and girls who perceived that their be …
Understanding the correlates of meal-skipping behaviours is important for the design of nutrition interventions. ...Best friend and m …
The rapidly evolving landscape of novel targeted therapies in advanced non-small cell lung cancer.
Melosky B, Wheatley-Price P, Juergens RA, Sacher A, Leighl NB, Tsao MS, Cheema P, Snow S, Liu G, Card PB, Chu Q. Melosky B, et al. Lung Cancer. 2021 Oct;160:136-151. doi: 10.1016/j.lungcan.2021.06.002. Epub 2021 Jun 5. Lung Cancer. 2021. PMID: 34353680 Review.
This rapidly evolving field has produced many new targeted treatment options and promising outcomes have led to the FDA approval of seven novel agents for use in ROS1-rearranged, BRAF V600E-mutant, NTRK-rearranged, MET exon 14 skipping-mutant or RET-rearranged advanced NSC …
This rapidly evolving field has produced many new targeted treatment options and promising outcomes have led to the FDA approval of seven no …
AIFM1-associated X-linked spondylometaphyseal dysplasia with cerebral hypomyelination.
Edgerley K, Barnicoat A, Offiah AC, Calder AD, Mankad K, Thomas NS, Bunyan DJ, Williams M, Buxton C, Majumdar A, Vijayakumar K, Hilliard T, Turner J, Burren CP, Monsell F, Smithson SF. Edgerley K, et al. Am J Med Genet A. 2021 Apr;185(4):1228-1235. doi: 10.1002/ajmg.a.62072. Epub 2021 Jan 13. Am J Med Genet A. 2021. PMID: 33439541 Free article.
Here we describe two further affected boys, one with a novel intronic variant associated with skipping of Exon 7 of AIFM1 and the other a synonymous variant within Exon 7 of AIFM1. ...
Here we describe two further affected boys, one with a novel intronic variant associated with skipping of Exon 7 of AIFM1 and the oth …
RNA modulation, repair and remodeling by splice switching oligonucleotides.
Kole R, Williams T, Cohen L. Kole R, et al. Acta Biochim Pol. 2004;51(2):373-8. Acta Biochim Pol. 2004. PMID: 15218534 Free article. Review.
By preventing the use of an aberrant splice site created by a mutation and enforcing re-selection of correct splice sites the RNA is repaired. Antisense induced skipping of the exon that carries a nonsense mutation remodels the mRNA and restores the reading frame of the de …
By preventing the use of an aberrant splice site created by a mutation and enforcing re-selection of correct splice sites the RNA is repaire …
79 results