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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1870 1
1916 1
1921 3
1922 4
1931 1
1932 1
1933 2
1935 1
1936 1
1937 1
1939 1
1940 1
1941 1
1942 2
1943 1
1945 2
1946 2
1947 5
1948 3
1949 2
1951 3
1952 3
1953 8
1954 6
1955 4
1956 5
1957 5
1958 5
1959 6
1960 3
1961 13
1962 10
1963 7
1964 17
1965 33
1966 41
1967 48
1968 61
1969 87
1970 83
1971 113
1972 158
1973 156
1974 189
1975 649
1976 771
1977 867
1978 831
1979 943
1980 926
1981 882
1982 972
1983 1122
1984 1071
1985 1065
1986 1038
1987 1039
1988 1116
1989 1169
1990 1093
1991 1038
1992 1081
1993 1111
1994 1020
1995 1029
1996 1194
1997 1098
1998 1150
1999 1227
2000 1360
2001 1397
2002 1465
2003 1563
2004 1594
2005 1715
2006 1873
2007 1960
2008 2152
2009 2182
2010 2339
2011 2549
2012 2758
2013 2617
2014 2798
2015 3189
2016 3175
2017 3444
2018 3830
2019 4352
2020 4728
2021 5081
2022 5264
2023 5103
2024 2172

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89,422 results

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Page 1
C3-dependent effector functions of complement.
Zarantonello A, Revel M, Grunenwald A, Roumenina LT. Zarantonello A, et al. Immunol Rev. 2023 Jan;313(1):120-138. doi: 10.1111/imr.13147. Epub 2022 Oct 22. Immunol Rev. 2023. PMID: 36271889 Free PMC article. Review.
We will introduce the C3 forms (native C3, C3 [H(2) O], and intracellular C3), the C3 fragments C3a, C3b, iC3b, and C3dg/C3d, and the C3 expression sites. To highlight the important role that C3 plays in human biological processes, …
We will introduce the C3 forms (native C3, C3 [H(2) O], and intracellular C3), the C3 fragments C3a, C3b, …
A Narrative Review on C3 Glomerulopathy: A Rare Renal Disease.
Schena FP, Esposito P, Rossini M. Schena FP, et al. Int J Mol Sci. 2020 Jan 14;21(2):525. doi: 10.3390/ijms21020525. Int J Mol Sci. 2020. PMID: 31947692 Free PMC article. Review.
In April 2012, a group of nephrologists organized a consensus conference in Cambridge (UK) on type II membranoproliferative glomerulonephritis and decided to use a new terminology, "C3 glomerulopathy" (C3 GP). Further knowledge on the complement system and on kidney …
In April 2012, a group of nephrologists organized a consensus conference in Cambridge (UK) on type II membranoproliferative glomerulonephrit …
C3 Glomerulopathy.
Riedl M, Thorner P, Licht C. Riedl M, et al. Pediatr Nephrol. 2017 Jan;32(1):43-57. doi: 10.1007/s00467-015-3310-4. Epub 2016 Apr 7. Pediatr Nephrol. 2017. PMID: 27056062 Review.
In C3G, loss of AP regulation leads to predominant glomerular C3 deposition, which distinguishes C3G from IC-GN with predominant immunoglobulin G staining. ...Mutations or autoantibodies affecting the function of AP activators or regulators, in particular the decay of the …
In C3G, loss of AP regulation leads to predominant glomerular C3 deposition, which distinguishes C3G from IC-GN with predominant immu …
With complements: C3 inhibition in the clinic.
Kolev M, Barbour T, Baver S, Francois C, Deschatelets P. Kolev M, et al. Immunol Rev. 2023 Jan;313(1):358-375. doi: 10.1111/imr.13138. Epub 2022 Sep 25. Immunol Rev. 2023. PMID: 36161656 Review.
C3 is a key complement protein, located at the nexus of all complement activation pathways. ...In this review, we compare the MoA of pegcetacoplan and eculizumab in paroxysmal nocturnal hemoglobinuria and discuss the complement-mediated disease that might be amenable to …
C3 is a key complement protein, located at the nexus of all complement activation pathways. ...In this review, we compare the MoA of …
Emerging opportunities for C3 inhibition in the eye.
Kim BJ, Liu T, Mastellos DC, Lambris JD. Kim BJ, et al. Semin Immunol. 2022 Jan;59:101633. doi: 10.1016/j.smim.2022.101633. Epub 2022 Jul 2. Semin Immunol. 2022. PMID: 35787973 Review.
This article will discuss the location of C3 expression in the eye as well as the preclinical and clinical data regarding C3's functions in AMD. We will provide a comprehensive review of developing C3 inhibitors for the eye, including the Phase 2 and 3 data f …
This article will discuss the location of C3 expression in the eye as well as the preclinical and clinical data regarding C3's …
Humanized C3 Mouse: A Novel Accelerated Model of C3 Glomerulopathy.
Devalaraja-Narashimha K, Meagher K, Luo Y, Huang C, Kaplan T, Muthuswamy A, Halasz G, Casanova S, O'Brien J, Peyser Boiarsky R, McWhirter J, Gartner H, Bai Y, MacDonnell S, Liu C, Hu Y, Latuszek A, Wei Y, Prasad S, Huang T, Yancopoulos G, Murphy A, Olson W, Zambrowicz B, Macdonald L, Morton LG. Devalaraja-Narashimha K, et al. J Am Soc Nephrol. 2021 Jan;32(1):99-114. doi: 10.1681/ASN.2020050698. Epub 2020 Dec 7. J Am Soc Nephrol. 2021. PMID: 33288630 Free PMC article.
The C3(hu/hu) mice display elevated biomarkers of kidney dysfunction, glomerulosclerosis, C3/C5b-9 deposition, and reduced circulating C3 compared with wild-type mice. ...The C3G phenotype in C3(hu/hu) mice may originate from a dysregulated interaction …
The C3(hu/hu) mice display elevated biomarkers of kidney dysfunction, glomerulosclerosis, C3/C5b-9 deposition, and reduced cir …
C3 deficiencies.
Bitter-Suermann D, Burger R. Bitter-Suermann D, et al. Curr Top Microbiol Immunol. 1990;153:223-33. doi: 10.1007/978-3-642-74977-3_12. Curr Top Microbiol Immunol. 1990. PMID: 2404696 Review. No abstract available.
Complement C3-targeted therapy in C3 glomerulopathy, a prototype of complement-mediated kidney diseases.
Meuleman MS, Grunenwald A, Chauvet S. Meuleman MS, et al. Semin Immunol. 2022 Mar;60:101634. doi: 10.1016/j.smim.2022.101634. Epub 2022 Jul 8. Semin Immunol. 2022. PMID: 35817659 Review.
C3 glomerulopathy (C3G) is a rare and complex kidney disease that primarily affects young adults. ...However, the lack of sufficient efficiency in anti-C5 therapy highlights the extreme complexity of the disease and the need for new therapeutic approaches based on C3 …
C3 glomerulopathy (C3G) is a rare and complex kidney disease that primarily affects young adults. ...However, the lack of sufficient …
Serum IgA/C3 ratio and glomerular C3 staining predict progression of IgA nephropathy in children.
Lang Y, Song S, Zhao L, Yang Y, Liu T, Shen Y, Wang W. Lang Y, et al. Transl Pediatr. 2021 Mar;10(3):666-672. doi: 10.21037/tp-21-90. Transl Pediatr. 2021. PMID: 33880336 Free PMC article.
Receiver operating characteristic (ROC) curves were used to evaluate the optimal cutoff value of serum IgA/C3 ratio in two groups. According to the optimal cutoff value of serum IgA/C3 ratio and glomerular C3 staining, the children were divided into four grou …
Receiver operating characteristic (ROC) curves were used to evaluate the optimal cutoff value of serum IgA/C3 ratio in two groups. Ac …
Structure and expression of the C3 gene.
Fey G, Domdey H, Wiebauer K, Whitehead AS, Odink K. Fey G, et al. Springer Semin Immunopathol. 1983;6(2-3):119-47. doi: 10.1007/BF00205869. Springer Semin Immunopathol. 1983. PMID: 6356427 Free article. Review.
This review summarizes the currently known molecular properties of mouse liver C3 mRNA, cloned C3 cDNA, and genomic DNA. Original data communicated have specified the amino acid sequence of the 215 amino-terminal residues of mature mouse C3 beta. Southern blo …
This review summarizes the currently known molecular properties of mouse liver C3 mRNA, cloned C3 cDNA, and genomic DNA. Origi …
89,422 results
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