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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2004 1
2006 1
2008 1
2009 1
2013 1
2014 1
2015 3
2016 6
2017 1
2018 2
2019 4
2020 1
2021 4
2022 4
2023 5
2024 1

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32 results

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Page 1
Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors.
Adalsteinsson VA, Ha G, Freeman SS, Choudhury AD, Stover DG, Parsons HA, Gydush G, Reed SC, Rotem D, Rhoades J, Loginov D, Livitz D, Rosebrock D, Leshchiner I, Kim J, Stewart C, Rosenberg M, Francis JM, Zhang CZ, Cohen O, Oh C, Ding H, Polak P, Lloyd M, Mahmud S, Helvie K, Merrill MS, Santiago RA, O'Connor EP, Jeong SH, Leeson R, Barry RM, Kramkowski JF, Zhang Z, Polacek L, Lohr JG, Schleicher M, Lipscomb E, Saltzman A, Oliver NM, Marini L, Waks AG, Harshman LC, Tolaney SM, Van Allen EM, Winer EP, Lin NU, Nakabayashi M, Taplin ME, Johannessen CM, Garraway LA, Golub TR, Boehm JS, Wagle N, Getz G, Love JC, Meyerson M. Adalsteinsson VA, et al. Nat Commun. 2017 Nov 6;8(1):1324. doi: 10.1038/s41467-017-00965-y. Nat Commun. 2017. PMID: 29109393 Free PMC article.
Membrane mimetic-dependence of GPCR energy landscapes.
Thakur N, Ray AP, Jin B, Afsharian NP, Lyman E, Gao ZG, Jacobson KA, Eddy MT. Thakur N, et al. Structure. 2024 May 2;32(5):523-535.e5. doi: 10.1016/j.str.2024.01.013. Epub 2024 Feb 23. Structure. 2024. PMID: 38401537
We leveraged variable-temperature (19)F-NMR spectroscopy to compare the conformational equilibria of the human A(2A) adenosine receptor (A(2A)AR), a class A G protein-coupled receptor (GPCR), across a range of temperatures ranging from lower temperatures typically e …
We leveraged variable-temperature (19)F-NMR spectroscopy to compare the conformational equilibria of the human A(2A) adenosine receptor (A(2 …
Anionic phospholipids control mechanisms of GPCR-G protein recognition.
Thakur N, Ray AP, Sharp L, Jin B, Duong A, Pour NG, Obeng S, Wijesekara AV, Gao ZG, McCurdy CR, Jacobson KA, Lyman E, Eddy MT. Thakur N, et al. Nat Commun. 2023 Feb 13;14(1):794. doi: 10.1038/s41467-023-36425-z. Nat Commun. 2023. PMID: 36781870 Free PMC article.
In computational models, anionic lipids mimic interactions between a G protein and positively charged residues in A(2A)AR at the receptor intracellular surface, stabilizing a pre-activated receptor conformation. ...
In computational models, anionic lipids mimic interactions between a G protein and positively charged residues in A(2A)AR at t …
Slow conformational dynamics of the human A2A adenosine receptor are temporally ordered.
Wei S, Thakur N, Ray AP, Jin B, Obeng S, McCurdy CR, McMahon LR, Gutiérrez-de-Terán H, Eddy MT, Lamichhane R. Wei S, et al. Structure. 2022 Mar 3;30(3):329-337.e5. doi: 10.1016/j.str.2021.11.005. Epub 2021 Dec 10. Structure. 2022. PMID: 34895472 Free PMC article.
We used total internal reflection fluorescence (TIRF) imaging to investigate the conformational dynamics of the human A(2A) adenosine receptor (A(2A)AR), a class A G protein-coupled receptor (GPCR), at the single-molecule level. ...
We used total internal reflection fluorescence (TIRF) imaging to investigate the conformational dynamics of the human A(2A) adenosine recept …
Production of human A2AAR in lipid nanodiscs for 19F-NMR and single-molecule fluorescence spectroscopy.
Thakur N, Wei S, Ray AP, Lamichhane R, Eddy MT. Thakur N, et al. STAR Protoc. 2022 Sep 16;3(3):101535. doi: 10.1016/j.xpro.2022.101535. Epub 2022 Jul 13. STAR Protoc. 2022. PMID: 35839771 Free PMC article.
We describe production of the human A(2A) adenosine receptor (A(2A)AR), a class A G protein-coupled receptor (GPCR) for (19)F-NMR and single-molecule fluorescence (SMF) spectroscopy. ...
We describe production of the human A(2A) adenosine receptor (A(2A)AR), a class A G protein-coupled receptor (GPCR) for (19)F- …
Surface Plasmon Resonance Analysis of PfEMP1 Interaction with Receptors.
Lennartz F, Higgins MK. Lennartz F, et al. Methods Mol Biol. 2022;2470:467-482. doi: 10.1007/978-1-0716-2189-9_35. Methods Mol Biol. 2022. PMID: 35881367
This chapter focuses on using surface plasmon resonance (SPR) as a reproducible, high-throughput method to quantitatively characterize these interactions. We describe how to utilize protein A or A/G and streptavidin for protein immobilization on SPR sensor chips and …
This chapter focuses on using surface plasmon resonance (SPR) as a reproducible, high-throughput method to quantitatively characterize these …
Fixation biases affecting human SNPs.
Webster MT, Smith NG. Webster MT, et al. Trends Genet. 2004 Mar;20(3):122-6. doi: 10.1016/j.tig.2004.01.005. Trends Genet. 2004. PMID: 15049304 Review.
Furthermore, in transcribed regions this process exhibits strand asymmetry, and is biased towards preserving a G base on the coding strand. Biased gene conversion has the potential to explain both existence of isochores and the compositional asymmetry in mammalian t …
Furthermore, in transcribed regions this process exhibits strand asymmetry, and is biased towards preserving a G base on the c …
32 results