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Complement C3-Targeted Gene Therapy Restricts Onset and Progression of Neurodegeneration in Chronic Mouse Glaucoma.
Bosco A, Anderson SR, Breen KT, Romero CO, Steele MR, Chiodo VA, Boye SL, Hauswirth WW, Tomlinson S, Vetter ML. Bosco A, et al. Mol Ther. 2018 Oct 3;26(10):2379-2396. doi: 10.1016/j.ymthe.2018.08.017. Epub 2018 Aug 24. Mol Ther. 2018. PMID: 30217731 Free PMC article.
Because complement signals through three pathways that intersect at complement C3 activation, here we targeted this step to restore complement balance in the glaucomatous retina and to determine its contribution to degeneration onset and/or progression. ...This resulted in …
Because complement signals through three pathways that intersect at complement C3 activation, here we targeted this step to restore c …
Regulation of pancreatic beta-cell insulin secretion by actin cytoskeleton remodelling: role of gelsolin and cooperation with the MAPK signalling pathway.
Tomas A, Yermen B, Min L, Pessin JE, Halban PA. Tomas A, et al. J Cell Sci. 2006 May 15;119(Pt 10):2156-67. doi: 10.1242/jcs.02942. Epub 2006 Apr 25. J Cell Sci. 2006. PMID: 16638805 Free article.
Consistent with these data, B1 cells display glucose-dependent actin remodelling whereas, in C3 cells, F-actin is refractory to this secretagogue. Furthermore, F-actin depolymerisation with latrunculin B restores glucose-stimulated insulin secretion in C3 cells. In …
Consistent with these data, B1 cells display glucose-dependent actin remodelling whereas, in C3 cells, F-actin is refractory to this …