Diverse priming outcomes under conditions of very rare precursor B cells.
Madden PJ, Marina-Zárate E, Rodrigues KA, Steichen JM, Shil M, Ni K, Michaels KK, Maiorino L, Upadhyay AA, Saha S, Pradhan A, Kalyuzhiny O, Liguori A, Lopez PG, Phung I, Phelps N, Georgeson E, Alavi N, Kubitz M, Lu D, Eskandarzadeh S, Metz A, Rodriguez OL, Shields K, Schultze S, Smith ML, Healy BS, Lim D, Lewis VR, Ben-Akiva E, Pinney W, Gregory J, Xiao S, Carnathan DG, Kasturi SP, Watson CT, Bosinger SE, Silvestri G, Schief WR, Irvine DJ, Crotty S.
Madden PJ, et al.
bioRxiv [Preprint]. 2024 Nov 25:2024.11.21.624746. doi: 10.1101/2024.11.21.624746.
bioRxiv. 2024.
PMID: 39651117
Free PMC article.
Preprint.
Rare B cells can have special pathogen-recognition features giving them the potential to make outsized contributions to protective immunity. ...All groups had strong GC responses, but only ED+SMNP and bolus+SMNP induced BG18-like memory B cells in >50% of animals …
Rare B cells can have special pathogen-recognition features giving them the potential to make outsized contributions to protective im …