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A large-scale comparative analysis of affinity, thermodynamics and functional characteristics of interactions of twelve cytochrome P450 isoforms and their redox partners.
Yablokov EO, Sushko TA, Ershov PV, Florinskaya AV, Gnedenko OV, Shkel TV, Grabovec IP, Strushkevich NV, Kaluzhskiy LA, Usanov SA, Gilep AA, Ivanov AS. Yablokov EO, et al. Among authors: grabovec ip. Biochimie. 2019 Jul;162:156-166. doi: 10.1016/j.biochi.2019.04.020. Epub 2019 Apr 26. Biochimie. 2019. PMID: 31034920
Different inhibitory effects of azole-containing drugs and pesticides on CYP2C9 polymorphic forms: An in vitro study.
Haidukevich IV, Sushko TA, Tumilovich AM, Grabovec IP, Usanov SA, Gilep AA. Haidukevich IV, et al. Among authors: grabovec ip. Toxicol In Vitro. 2018 Aug;50:249-256. doi: 10.1016/j.tiv.2018.04.002. Epub 2018 Apr 3. Toxicol In Vitro. 2018. PMID: 29621561
Structural characterization of human cholesterol 7α-hydroxylase.
Tempel W, Grabovec I, MacKenzie F, Dichenko YV, Usanov SA, Gilep AA, Park HW, Strushkevich N. Tempel W, et al. Among authors: grabovec i. J Lipid Res. 2014 Sep;55(9):1925-32. doi: 10.1194/jlr.M050765. Epub 2014 Jun 13. J Lipid Res. 2014. PMID: 24927729 Free PMC article.
Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system.
Strushkevich N, MacKenzie F, Cherkesova T, Grabovec I, Usanov S, Park HW. Strushkevich N, et al. Among authors: grabovec i. Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10139-43. doi: 10.1073/pnas.1019441108. Epub 2011 Jun 2. Proc Natl Acad Sci U S A. 2011. PMID: 21636783 Free PMC article.
Adrenodoxin supports reactions catalyzed by microsomal steroidogenic cytochrome P450s.
Pechurskaya TA, Harnastai IN, Grabovec IP, Gilep AA, Usanov SA. Pechurskaya TA, et al. Among authors: grabovec ip. Biochem Biophys Res Commun. 2007 Feb 16;353(3):598-604. doi: 10.1016/j.bbrc.2006.12.047. Epub 2006 Dec 15. Biochem Biophys Res Commun. 2007. PMID: 17188650
Hydroxylation of Antitubercular Drug Candidate, SQ109, by Mycobacterial Cytochrome P450.
Bukhdruker S, Varaksa T, Grabovec I, Marin E, Shabunya P, Kadukova M, Grudinin S, Kavaleuski A, Gusach A, Gilep A, Borshchevskiy V, Strushkevich N. Bukhdruker S, et al. Among authors: grabovec i. Int J Mol Sci. 2020 Oct 16;21(20):7683. doi: 10.3390/ijms21207683. Int J Mol Sci. 2020. PMID: 33081390 Free PMC article.