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Did you mean karen Last (162 results)?
An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2.
Miller RE, Ishihara S, Tran PB, Golub SB, Last K, Miller RJ, Fosang AJ, Malfait AM. Miller RE, et al. Among authors: Last K. JCI Insight. 2018 Mar 22;3(6):e95704. doi: 10.1172/jci.insight.95704. JCI Insight. 2018. PMID: 29563338 Free PMC article.
A Disintegrin and Metalloproteinase with Thrombospondin Motifs-5 (ADAMTS-5) Forms Catalytically Active Oligomers.
Kosasih HJ, Last K, Rogerson FM, Golub SB, Gauci SJ, Russo VC, Stanton H, Wilson R, Lamande SR, Holden P, Fosang AJ. Kosasih HJ, et al. Among authors: Last K. J Biol Chem. 2016 Feb 12;291(7):3197-208. doi: 10.1074/jbc.M115.704817. Epub 2015 Dec 14. J Biol Chem. 2016. PMID: 26668318 Free PMC article.
Investigating ADAMTS-mediated aggrecanolysis in mouse cartilage.
Stanton H, Golub SB, Rogerson FM, Last K, Little CB, Fosang AJ. Stanton H, et al. Among authors: Last K. Nat Protoc. 2011 Mar;6(3):388-404. doi: 10.1038/nprot.2010.179. Epub 2011 Mar 3. Nat Protoc. 2011. PMID: 21372818
Neoepitope antibodies against MMP-cleaved and aggrecanase-cleaved aggrecan.
Fosang AJ, Last K, Stanton H, Golub SB, Little CB, Brown L, Jackson DC. Fosang AJ, et al. Among authors: Last K. Methods Mol Biol. 2010;622:312-47. doi: 10.1007/978-1-60327-299-5_19. Methods Mol Biol. 2010. PMID: 20135291
ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro.
Stanton H, Rogerson FM, East CJ, Golub SB, Lawlor KE, Meeker CT, Little CB, Last K, Farmer PJ, Campbell IK, Fourie AM, Fosang AJ. Stanton H, et al. Among authors: Last K. Nature. 2005 Mar 31;434(7033):648-52. doi: 10.1038/nature03417. Nature. 2005. PMID: 15800625 Free article.
Aggrecanase cleavage in juvenile idiopathic arthritis patients is minimally detected in the aggrecan interglobular domain but robust at the aggrecan C-terminus.
Struglics A, Lohmander LS, Last K, Akikusa J, Allen R, Fosang AJ. Struglics A, et al. Among authors: Last K. Arthritis Rheum. 2012 Dec;64(12):4151-61; author reply 4162-3. doi: 10.1002/art.34665. Arthritis Rheum. 2012. PMID: 22886575 Free article.
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