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Mistranslation: from adaptations to applications.

Hoffman KS, O'Donoghue P, Brandl CJ. Hoffman KS, et al. Biochim Biophys Acta Gen Subj. 2017 Nov;1861(11 Pt B):3070-3080. doi: 10.1016/j.bbagen.2017.01.031. Epub 2017 Jan 30. Biochim Biophys Acta Gen Subj. 2017. PMID: 28153753 Review.

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Versatility of Synthetic tRNAs in Genetic Code Expansion.

Hoffman KS, Crnković A, Söll D. Hoffman KS, et al. Genes (Basel). 2018 Nov 7;9(11):537. doi: 10.3390/genes9110537. Genes (Basel). 2018. PMID: 30405060 Free PMC article. Review.

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Bacterial translation machinery for deliberate mistranslation of the genetic code.

Vargas-Rodriguez O, Badran AH, Hoffman KS, Chen M, Crnković A, Ding Y, Krieger JR, Westhof E, Söll D, Melnikov S. Vargas-Rodriguez O, et al. Among authors: hoffman ks. Proc Natl Acad Sci U S A. 2021 Aug 31;118(35):e2110797118. doi: 10.1073/pnas.2110797118. Proc Natl Acad Sci U S A. 2021. PMID: 34413202 Free PMC article.

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Visualizing tRNA-dependent mistranslation in human cells.

Lant JT, Berg MD, Sze DHW, Hoffman KS, Akinpelu IC, Turk MA, Heinemann IU, Duennwald ML, Brandl CJ, O'Donoghue P. Lant JT, et al. Among authors: hoffman ks. RNA Biol. 2018;15(4-5):567-575. doi: 10.1080/15476286.2017.1379645. Epub 2017 Nov 9. RNA Biol. 2018. PMID: 28933646 Free PMC article.

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Translation of Diverse Aramid- and 1,3-Dicarbonyl-peptides by Wild Type Ribosomes in Vitro.

Ad O, Hoffman KS, Cairns AG, Featherston AL, Miller SJ, Söll D, Schepartz A. Ad O, et al. Among authors: hoffman ks. ACS Cent Sci. 2019 Jul 24;5(7):1289-1294. doi: 10.1021/acscentsci.9b00460. Epub 2019 Jun 26. ACS Cent Sci. 2019. PMID: 31403077 Free PMC article.

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Covalent Immune Proximity-Induction Strategy Using SuFEx-Engineered Bifunctional Viral Peptides.

McCann HM, Lake BPM, Hoffman KS, Davola ME, Mossman KL, Rullo AF. McCann HM, et al. Among authors: hoffman ks. ACS Chem Biol. 2022 May 20;17(5):1269-1281. doi: 10.1021/acschembio.2c00233. Epub 2022 May 6. ACS Chem Biol. 2022. PMID: 35522208

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Genetic selection for mistranslation rescues a defective co-chaperone in yeast.

Hoffman KS, Berg MD, Shilton BH, Brandl CJ, O'Donoghue P. Hoffman KS, et al. Nucleic Acids Res. 2017 Apr 7;45(6):3407-3421. doi: 10.1093/nar/gkw1021. Nucleic Acids Res. 2017. PMID: 27899648 Free PMC article.

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Saccharomyces cerevisiae Tti2 Regulates PIKK Proteins and Stress Response.

Hoffman KS, Duennwald ML, Karagiannis J, Genereaux J, McCarton AS, Brandl CJ. Hoffman KS, et al. G3 (Bethesda). 2016 Jun 1;6(6):1649-59. doi: 10.1534/g3.116.029520. G3 (Bethesda). 2016. PMID: 27172216 Free PMC article.

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A cysteinyl-tRNA synthetase variant confers resistance against selenite toxicity and decreases selenocysteine misincorporation.

Hoffman KS, Vargas-Rodriguez O, Bak DW, Mukai T, Woodward LK, Weerapana E, Söll D, Reynolds NM. Hoffman KS, et al. J Biol Chem. 2019 Aug 23;294(34):12855-12865. doi: 10.1074/jbc.RA119.008219. Epub 2019 Jul 11. J Biol Chem. 2019. PMID: 31296657 Free PMC article.

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Evolving Mistranslating tRNAs Through a Phenotypically Ambivalent Intermediate in Saccharomyces cerevisiae.

Berg MD, Hoffman KS, Genereaux J, Mian S, Trussler RS, Haniford DB, O'Donoghue P, Brandl CJ. Berg MD, et al. Among authors: hoffman ks. Genetics. 2017 Aug;206(4):1865-1879. doi: 10.1534/genetics.117.203232. Epub 2017 Jun 2. Genetics. 2017. PMID: 28576863 Free PMC article.

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