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p38γ MAPK contributes to left ventricular remodeling after pathologic stress and disinhibits calpain through phosphorylation of calpastatin.
Loonat AA, Martin ED, Sarafraz-Shekary N, Tilgner K, Hertz NT, Levin R, Shokat KM, Burlingame AL, Arabacilar P, Uddin S, Thomas M, Marber MS, Clark JE. Loonat AA, et al. FASEB J. 2019 Dec;33(12):13131-13144. doi: 10.1096/fj.201701545R. Epub 2019 Oct 22. FASEB J. 2019. PMID: 31638431 Free PMC article.
In addition, we have identified calpastatin, among other substrates, as a novel direct target of p38gamma that may contribute to the protection observed in p38gammaKO mice.-Loonat, A. A., Martin, E. D., Sarafraz-Shekary, N., Tilgner, K., Hertz, N. T., Levin, R., Shokat, K. …
In addition, we have identified calpastatin, among other substrates, as a novel direct target of p38gamma that may contribute to the protect …
Molecular evaluation of pvdhfr and pvmdr-1 mutants in Plasmodium vivax isolates after treatment with sulfadoxine/pyrimethamine and chloroquine in Iran during 2001-2016.
Parsaei M, Raeisi A, Spotin A, Shahbazi A, Mahami-Oskouei M, Hazratian T, Khorashad AS, Zaman J, Bazmani A, Sarafraz S. Parsaei M, et al. Infect Genet Evol. 2018 Oct;64:70-75. doi: 10.1016/j.meegid.2018.06.021. Epub 2018 Jun 19. Infect Genet Evol. 2018. PMID: 29929007
The genomic DNA was extracted and examined using nested polymerase chain reaction-(PCR) and sequencing. Mutations were detected in pvdhfr codons P33L (21.2%), T61 M (25%), S93H (3.9%), and S117 T (1.9%) and 5 isolates showed double mutations (33 L/61 M, 7.7%; 33 L/1 …
The genomic DNA was extracted and examined using nested polymerase chain reaction-(PCR) and sequencing. Mutations were detected in pvdhfr co …