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4,661 results

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The following term was not found in PubMed: Vershuuren
Page 1
Pim Kinases: Important Regulators of Cardiovascular Disease.
Nock S, Karim E, Unsworth AJ. Nock S, et al. Int J Mol Sci. 2023 Jul 18;24(14):11582. doi: 10.3390/ijms241411582. Int J Mol Sci. 2023. PMID: 37511341 Free PMC article. Review.
Pim Kinases; Pim-1, Pim-2, and Pim-3, are a family of constitutively active serine/threonine kinases, widely associated with cell survival, proliferation, and migration. ...In this review, we discuss what is known about Pim kinase expression and …
Pim Kinases; Pim-1, Pim-2, and Pim-3, are a family of constitutively active serine/threonine kinases, widely ass …
Targeting Pim kinases in hematological cancers: molecular and clinical review.
Bellon M, Nicot C. Bellon M, et al. Mol Cancer. 2023 Jan 25;22(1):18. doi: 10.1186/s12943-023-01721-1. Mol Cancer. 2023. PMID: 36694243 Free PMC article. Review.
Decades of research has recognized a solid role for Pim kinases in lymphoproliferative disorders. Often up-regulated following JAK/STAT and tyrosine kinase receptor signaling, Pim kinases regulate cell proliferation, survival, metabolism, cellular trafficking and si …
Decades of research has recognized a solid role for Pim kinases in lymphoproliferative disorders. Often up-regulated following JAK/ST …
PIM Kinases in Multiple Myeloma.
Wu J, Chu E, Kang Y. Wu J, et al. Cancers (Basel). 2021 Aug 26;13(17):4304. doi: 10.3390/cancers13174304. Cancers (Basel). 2021. PMID: 34503111 Free PMC article. Review.
This review provides a comprehensive overview of the PIM kinase pathways and the current research status of the development of PIM kinase inhibitors for the treatment of MM. Additionally, the combinatorial effects of the PIM kinase inhibitors with other targe …
This review provides a comprehensive overview of the PIM kinase pathways and the current research status of the development of PIM …
The role of Pim kinase in immunomodulation.
Liu Z, Han M, Ding K, Fu R. Liu Z, et al. Am J Cancer Res. 2020 Dec 1;10(12):4085-4097. eCollection 2020. Am J Cancer Res. 2020. PMID: 33414987 Free PMC article. Review.
Pim kinase, which has three isozymes (Pim-1, Pim-2 and Pim-3), is a serine/threonine kinase abnormally expressed in many cancers. ...In recent years, researches verified the role of Pim kinase in immunomodulation. The mechanisms by which Pim …
Pim kinase, which has three isozymes (Pim-1, Pim-2 and Pim-3), is a serine/threonine kinase abnormally expressed …
PIM kinases regulate early human Th17 cell differentiation.
Buchacher T, Shetty A, Koskela SA, Smolander J, Kaukonen R, Sousa AGG, Junttila S, Laiho A, Rundquist O, Lönnberg T, Marson A, Rasool O, Elo LL, Lahesmaa R. Buchacher T, et al. Cell Rep. 2023 Dec 26;42(12):113469. doi: 10.1016/j.celrep.2023.113469. Epub 2023 Nov 30. Cell Rep. 2023. PMID: 38039135 Free PMC article.
The serine/threonine-specific Moloney murine leukemia virus (PIM) kinase family (i.e., PIM1, PIM2, and PIM3) has been extensively studied in tumorigenesis. PIM kinases are downstream of several cytokine signaling pathways that drive immune-mediated diseases. ...
The serine/threonine-specific Moloney murine leukemia virus (PIM) kinase family (i.e., PIM1, PIM2, and PIM3) has been extensively stu …
PIM kinase inhibitors: Structural and pharmacological perspectives.
Asati V, Mahapatra DK, Bharti SK. Asati V, et al. Eur J Med Chem. 2019 Jun 15;172:95-108. doi: 10.1016/j.ejmech.2019.03.050. Epub 2019 Mar 23. Eur J Med Chem. 2019. PMID: 30954777 Review.
The PIM kinase, also known as serine/threonine kinase plays an important role in cancer biology and is found in three different isoforms namely PIM-1, PIM-2, and PIM-3. ...Several medicinally privileged heterocyclic ring scaffolds such as pyrrole, pyri …
The PIM kinase, also known as serine/threonine kinase plays an important role in cancer biology and is found in three different isofo …
Targeting PIM Kinases to Improve the Efficacy of Immunotherapy.
Clements AN, Warfel NA. Clements AN, et al. Cells. 2022 Nov 21;11(22):3700. doi: 10.3390/cells11223700. Cells. 2022. PMID: 36429128 Free PMC article. Review.
The role of PIM in immune evasion has sparked interest in examining the effect of PIM inhibition in combination with immunotherapy. This review focuses on the role of PIM kinases in regulating immune cell populations, how PIM modulates the immune tumor …
The role of PIM in immune evasion has sparked interest in examining the effect of PIM inhibition in combination with immunothe …
An overview of pim kinase as a target in multiple myeloma.
Liu Z, Zhang Y, Guo Y, Wang H, Fu R. Liu Z, et al. Cancer Med. 2023 May;12(10):11746-11759. doi: 10.1002/cam4.5797. Epub 2023 May 10. Cancer Med. 2023. PMID: 37162273 Free PMC article. Review.
Therefore, pim kinase has become a potential therapeutic target in the treatment of MM and some pim kinase inhibitors have demonstrated good efficacy in clinical trials. ...Our analysis will guide the clinical use of pim kinase inhibitors for managing tumor l …
Therefore, pim kinase has become a potential therapeutic target in the treatment of MM and some pim kinase inhibitors have dem …
PIM Kinase as an Executional Target in Cancer.
Zhang X, Song M, Kundu JK, Lee MH, Liu ZZ. Zhang X, et al. J Cancer Prev. 2018 Sep;23(3):109-116. doi: 10.15430/JCP.2018.23.3.109. Epub 2018 Sep 30. J Cancer Prev. 2018. PMID: 30370255 Free PMC article. Review.
The aberrant expression and/or activation of PIM kinases in various cancers follow an isoform-specific pattern. ...This review sheds light on the signaling pathways involved in the PIM kinase regulation and current status of developing PIM kinase inhibitors a …
The aberrant expression and/or activation of PIM kinases in various cancers follow an isoform-specific pattern. ...This review sheds …
PIM kinases: From survival factors to regulators of cell motility.
Santio NM, Koskinen PJ. Santio NM, et al. Int J Biochem Cell Biol. 2017 Dec;93:74-85. doi: 10.1016/j.biocel.2017.10.016. Epub 2017 Nov 3. Int J Biochem Cell Biol. 2017. PMID: 29108877 Review.
Since high PIM expression levels have been connected to cancer progression and poor patient survival, PIM kinases have become attractive targets for drug development. Many downstream targets have also been identified, through which PIM kinases promote cell su …
Since high PIM expression levels have been connected to cancer progression and poor patient survival, PIM kinases have become …
4,661 results