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Levels of complement factor H-related 4 protein do not influence susceptibility to age-related macular degeneration or its course of progression.
Zouache MA, Richards BT, Pappas CM, Anstadt RA, Liu J, Corsetti T, Matthews S, Seager NA, Schmitz-Valckenberg S, Fleckenstein M, Hubbard WC, Thomas J, Hageman JL, Williams BL, Hageman GS. Zouache MA, et al. Nat Commun. 2024 Jan 10;15(1):443. doi: 10.1038/s41467-023-44605-0. Nat Commun. 2024. PMID: 38200010 Free PMC article.
A deficiency of mixed function oxidase activities in the cholesterol biosynthetic pathway of human granulocytes.
Shechter I, Fogelman AM, Popják G. Shechter I, et al. J Lipid Res. 1980 Mar;21(3):277-83. J Lipid Res. 1980. PMID: 7381322 Free article.
These results may provide an explanation for the accumulation of farnesol and squalene that has been previously observed in populations of mixed leukocytes (Fogelman, A. M., Edmond, J., Seager, J., and Popjak, G. (1975) J. Biol. Chem. 250: 2045-2055 (1 …
These results may provide an explanation for the accumulation of farnesol and squalene that has been previously observed in populations of m …
Mechanism of induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase in human leukocytes.
Fogelman AM, Seager J, Edwards PA, Popják G. Fogelman AM, et al. J Biol Chem. 1977 Jan 25;252(2):644-51. J Biol Chem. 1977. PMID: 833148 Free article.
The latter was shown previously to be proportional to the HMG-CoA reductase levels in the cells (Fogelman, A. M., Edmond, J., Seager, J., and Popjak, G. (1975)J. Biol. Chem. 250, 2045-2055). ...A close correlation between sterol loss and total sterol s …
The latter was shown previously to be proportional to the HMG-CoA reductase levels in the cells (Fogelman, A. M., Edmond, J., Seag …
Measurement of testicular volume in smaller testes: how accurate is the conventional orchidometer?
Lin CC, Huang WJ, Chen KK. Lin CC, et al. J Androl. 2009 Nov-Dec;30(6):685-9. doi: 10.2164/jandrol.108.006460. Epub 2009 Jul 3. J Androl. 2009. PMID: 19578133 Free article.
The aim of this study was to evaluate the accuracy of different methods, including the Seager orchidometer (SO) and ultrasonography (US), for assessing testicular volume of smaller testes (testes volume less than 18 mL). ...The testicular volume by water displacement was 8 …
The aim of this study was to evaluate the accuracy of different methods, including the Seager orchidometer (SO) and ultrasonography ( …
TESS DISCOVERY OF A TRANSITING SUPER-EARTH IN THE π MENSAE SYSTEM.
Huang CX, Burt J, Vanderburg A, Günther MN, Shporer A, Dittmann JA, Winn JN, Wittenmyer R, Sha L, Kane SR, Ricker GR, Vanderspek RK, Latham DW, Seager S, Jenkins JM, Caldwell DA, Collins KA, Guerrero N, Smith JC, Quinn SN, Udry S, Pepe F, Bouchy F, Ségransan D, Lovis C, Ehrenreich D, Marmier M, Mayor M, Wohler B, Haworth K, Morgan EH, Fausnaugh M, Ciardi DR, Christiansen J, Charbonneau D, Dragomir D, Deming D, Glidden A, Levine AM, McCullough PR, Yu L, Narita N, Nguyen T, Morton T, Pepper J, Pál A, Rodriguez JE; TESS team. Huang CX, et al. Astrophys J Lett. 2018 Dec 1;868(2):10.3847/2041-8213/aaef91. doi: 10.3847/2041-8213/aaef91. Epub 2018 Nov 30. Astrophys J Lett. 2018. PMID: 31360431 Free PMC article.
The solar-type host star is unusually bright (V = 5.7) and was already known to host a Jovian planet on a highly eccentric, 5.7-year orbit. The newly discovered planet has a size of 2.04 0.05 R () and an orbital period of 6.27 days. Radial-velocity data from the HARPS and …
The solar-type host star is unusually bright (V = 5.7) and was already known to host a Jovian planet on a highly eccentric, 5.7-year orbit. …
Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome.
Xie SC, Gillett DL, Spillman NJ, Tsu C, Luth MR, Ottilie S, Duffy S, Gould AE, Hales P, Seager BA, Charron CL, Bruzzese F, Yang X, Zhao X, Huang SC, Hutton CA, Burrows JN, Winzeler EA, Avery VM, Dick LR, Tilley L. Xie SC, et al. J Med Chem. 2018 Nov 21;61(22):10053-10066. doi: 10.1021/acs.jmedchem.8b01161. Epub 2018 Nov 7. J Med Chem. 2018. PMID: 30373366 Free PMC article.
Chromosome 10q26-driven age-related macular degeneration is associated with reduced levels of HTRA1 in human retinal pigment epithelium.
Williams BL, Seager NA, Gardiner JD, Pappas CM, Cronin MC, Amat di San Filippo C, Anstadt RA, Liu J, Toso MA, Nichols L, Parnell TJ, Eve JR, Heinz S, Hayes MGB, Bartel PL, Zouache MA, Richards BT, Hageman GS. Williams BL, et al. Proc Natl Acad Sci U S A. 2021 Jul 27;118(30):e2103617118. doi: 10.1073/pnas.2103617118. Proc Natl Acad Sci U S A. 2021. PMID: 34301870 Free PMC article.
To date, it has been difficult to assign causality to any specific single nucleotide polymorphism (SNP), haplotype, or gene within this region because of high linkage disequilibrium among the disease-associated variants [J. Jakobsdottir et al. Am. J. Hum. Genet. 77, …
To date, it has been difficult to assign causality to any specific single nucleotide polymorphism (SNP), haplotype, or gene within this regi …
17 results