Basement membrane stiffness determines metastases formation.
Reuten R, Zendehroud S, Nicolau M, Fleischhauer L, Laitala A, Kiderlen S, Nikodemus D, Wullkopf L, Nielsen SR, McNeilly S, Prein C, Rafaeva M, Schoof EM, Furtwängler B, Porse BT, Kim H, Won KJ, Sudhop S, Zornhagen KW, Suhr F, Maniati E, Pearce OMT, Koch M, Oddershede LB, Van Agtmael T, Madsen CD, Mayorca-Guiliani AE, Bloch W, Netz RR, Clausen-Schaumann H, Erler JT.
Reuten R, et al.
Nat Mater. 2021 Jun;20(6):892-903. doi: 10.1038/s41563-020-00894-0. Epub 2021 Jan 25.
Nat Mater. 2021.
PMID: 33495631
Free article.
The basement membrane (BM) is a special type of extracellular matrix and presents the major barrier cancer cells have to overcome multiple times to form metastases. Here we show that BM stiffness is a major determinant of metastases formation in several tissues and identif …
The basement membrane (BM) is a special type of extracellular matrix and presents the major barrier cancer cells have to overcome mul …