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2010 1
2011 1
2012 1
2013 1
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2017 3
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Page 1
Long-term safety and efficacy of ravulizumab in patients with paroxysmal nocturnal hemoglobinuria: 2-year results from two pivotal phase 3 studies.
Kulasekararaj AG, Griffin M, Langemeijer S, Usuki K, Kulagin A, Ogawa M, Yu J, Mujeebuddin A, Nishimura JI, Lee JW, Peffault de Latour R; 301/302 Study Group. Kulasekararaj AG, et al. Eur J Haematol. 2022 Sep;109(3):205-214. doi: 10.1111/ejh.13783. Epub 2022 Jun 16. Eur J Haematol. 2022. PMID: 35502600 Free PMC article. Clinical Trial.
OBJECTIVES: The complement component 5 (C5) inhibitor ravulizumab demonstrated non-inferiority to eculizumab following 26 weeks of treatment in complement inhibitor-naive and complement inhibitor-experienced patients with paroxysmal nocturnal hemoglobinuria (PNH; studies 3 …
OBJECTIVES: The complement component 5 (C5) inhibitor ravulizumab demonstrated non-inferiority to eculizumab following 26 weeks of tr …
Addition of danicopan to ravulizumab or eculizumab in patients with paroxysmal nocturnal haemoglobinuria and clinically significant extravascular haemolysis (ALPHA): a double-blind, randomised, phase 3 trial.
Lee JW, Griffin M, Kim JS, Lee Lee LW, Piatek C, Nishimura JI, Carrillo Infante C, Jain D, Liu P, Filippov G, Sicre de Fontbrune F, Risitano A, Kulasekararaj AG; ALXN2040-PNH-301 Investigators. Lee JW, et al. Lancet Haematol. 2023 Dec;10(12):e955-e965. doi: 10.1016/S2352-3026(23)00315-0. Lancet Haematol. 2023. PMID: 38030318 Clinical Trial.
BACKGROUND: Symptoms of anaemia due to clinically significant extravascular haemolysis can affect patients with paroxysmal nocturnal haemoglobinuria (PNH) treated with C5 inhibitors (ravulizumab or eculizumab). The aim of this study was to assess the efficacy and safety of …
BACKGROUND: Symptoms of anaemia due to clinically significant extravascular haemolysis can affect patients with paroxysmal nocturnal haemogl …
Elevated Hemidiaphragm.
Patel PR, Bechmann S. Patel PR, et al. 2023 Jul 31. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2023 Jul 31. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 32644681 Free Books & Documents.
The diaphragm is innervated by the ipsilateral phrenic nerve that arises from the cervical nerve roots of C3-C5. The phrenic nerve emerges through the anterior scalene muscle on either side of the neck and courses posteriorly to the subclavian vein. ...
The diaphragm is innervated by the ipsilateral phrenic nerve that arises from the cervical nerve roots of C3-C5. The phrenic nerve em …
Scrotal thermography.
Gold RH, Ehrlich RM, Samuels B, Dowdy A, Young RT. Gold RH, et al. Radiology. 1977 Jan;122(1):129-32. doi: 10.1148/122.1.129. Radiology. 1977. PMID: 830321
Systematic review of adapted physical activity and therapeutic education of patients with chronic venous disease.
Thibert A, Briche N, Vernizeau BD, Mougin-Guillaume F, Béliard S; Therapeutic Patient Education Working Group of the French Society of Vascular Medicine. Thibert A, et al. J Vasc Surg Venous Lymphat Disord. 2022 Nov;10(6):1385-1400. doi: 10.1016/j.jvsv.2022.05.004. Epub 2022 Jul 8. J Vasc Surg Venous Lymphat Disord. 2022. PMID: 35810994 Review.
RESULTS: A total of 21 studies were selected for analysis. The analysis revealed first, that patients at stage C0 to C5 had had access to an APA program. This therapy alleviated the clinical signs and symptoms and improved the patients' quality of life. ...
RESULTS: A total of 21 studies were selected for analysis. The analysis revealed first, that patients at stage C0 to C5 had had acces …
C5 Palsy After Cervical Spine Surgery: A Multicenter Retrospective Review of 59 Cases.
Thompson SE, Smith ZA, Hsu WK, Nassr A, Mroz TE, Fish DE, Wang JC, Fehlings MG, Tannoury CA, Tannoury T, Tortolani PJ, Traynelis VC, Gokaslan Z, Hilibrand AS, Isaacs RE, Mummaneni PV, Chou D, Qureshi SA, Cho SK, Baird EO, Sasso RC, Arnold PM, Buser Z, Bydon M, Clarke MJ, De Giacomo AF, Derakhshan A, Jobse B, Lord EL, Lubelski D, Massicotte EM, Steinmetz MP, Smith GA, Pace J, Corriveau M, Lee S, Cha PI, Chatterjee D, Gee EL, Mayer EN, McBride OJ, Roe AK, Yanez MY, Stroh DA, Than KD, Riew KD. Thompson SE, et al. Global Spine J. 2017 Apr;7(1 Suppl):64S-70S. doi: 10.1177/2192568216688189. Epub 2017 Apr 1. Global Spine J. 2017. PMID: 28451494 Free PMC article.
STUDY DESIGN: A multicenter, retrospective review of C5 palsy after cervical spine surgery. OBJECTIVE: Postoperative C5 palsy is a known complication of cervical decompressive spinal surgery. ...RESULTS: Of the 13 946 cases reviewed, 59 patients experienced a postop …
STUDY DESIGN: A multicenter, retrospective review of C5 palsy after cervical spine surgery. OBJECTIVE: Postoperative C5 palsy …
Alternative Complement Pathway Activation Provokes a Hypercoagulable State with Diminished Fibrinolysis.
Samuels JM, Coleman JR, Moore EE, Bartley M, Vigneshwar N, Cohen M, Silliman CC, Sauaia A, Banerjee A. Samuels JM, et al. Shock. 2020 May;53(5):560-565. doi: 10.1097/SHK.0000000000001437. Shock. 2020. PMID: 31441792 Free PMC article.
We hypothesize that activation of the alternative pathway triggers a hypercoagulable state. METHODS: C3/C5 convertase Cobra Venom Factor (CVF, 10 Units/mL) was employed to activate the alternative complement pathway in whole blood. ...
We hypothesize that activation of the alternative pathway triggers a hypercoagulable state. METHODS: C3/C5 convertase Cobra Venom Fac …
Rare Complications of Cervical Spine Surgery: Horner's Syndrome.
Traynelis VC, Malone HR, Smith ZA, Hsu WK, Kanter AS, Qureshi SA, Cho SK, Baird EO, Isaacs RE, Rahman RK, Polevaya G, Smith JS, Shaffrey C, Tortolani PJ, Stroh DA, Arnold PM, Fehlings MG, Mroz TE, Riew KD. Traynelis VC, et al. Global Spine J. 2017 Apr;7(1 Suppl):103S-108S. doi: 10.1177/2192568216688184. Epub 2017 Apr 1. Global Spine J. 2017. PMID: 28451480 Free PMC article.
The sympathetic trunk appeared to be more vulnerable when operating on midcervical levels (C5, C6), and most patients experienced at least a partial recovery without further treatment. ...
The sympathetic trunk appeared to be more vulnerable when operating on midcervical levels (C5, C6), and most patients experienced at …
27 results