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Trypanosuppressive effects of Kolaviron may be associated with down regulation of Trypanothione reductase in Trypanosoma congolense infection.
Timothy MR, Ibrahim YKE, Muhammad A, Chechet GD, Aimola IA, Mamman M. Timothy MR, et al. Trop Biomed. 2021 Mar 1;38(1):94-101. doi: 10.47665/tb.38.1.016. Trop Biomed. 2021. PMID: 33797530
Real-time PCR (qPCR) assay was implored to monitor expression of trypanothione reductase using primers targeting the 177-bp repeat satellite DNA in T. congolense with SYBR Green to monitor product accumulation. Kolaviron showed IC(50) values of 2.64mug/ml with % inhibition …
Real-time PCR (qPCR) assay was implored to monitor expression of trypanothione reductase using primers targeting the 177-bp repeat satellite …
Difference in mortality among individuals admitted to hospital with COVID-19 during the first and second waves in South Africa: a cohort study.
Jassat W, Mudara C, Ozougwu L, Tempia S, Blumberg L, Davies MA, Pillay Y, Carter T, Morewane R, Wolmarans M, von Gottberg A, Bhiman JN, Walaza S, Cohen C; DATCOV author group. Jassat W, et al. Lancet Glob Health. 2021 Sep;9(9):e1216-e1225. doi: 10.1016/S2214-109X(21)00289-8. Epub 2021 Jul 9. Lancet Glob Health. 2021. PMID: 34252381 Free PMC article.
Risk factors for COVID-19-related in-hospital mortality in a high HIV and tuberculosis prevalence setting in South Africa: a cohort study.
Jassat W, Cohen C, Tempia S, Masha M, Goldstein S, Kufa T, Murangandi P, Savulescu D, Walaza S, Bam JL, Davies MA, Prozesky HW, Naude J, Mnguni AT, Lawrence CA, Mathema HT, Zamparini J, Black J, Mehta R, Parker A, Chikobvu P, Dawood H, Muvhango N, Strydom R, Adelekan T, Mdlovu B, Moodley N, Namavhandu EL, Rheeder P, Venturas J, Magula N, Blumberg L; DATCOV author group. Jassat W, et al. Lancet HIV. 2021 Sep;8(9):e554-e567. doi: 10.1016/S2352-3018(21)00151-X. Epub 2021 Aug 4. Lancet HIV. 2021. PMID: 34363789 Free PMC article.