Small Molecules in the Treatment of Squamous Cell Carcinomas: Focus on Indirubins.
Schäfer M, Semmler ML, Bernhardt T, Fischer T, Kakkassery V, Ramer R, Hein M, Bekeschus S, Langer P, Hinz B, Emmert S, Boeckmann L.
Schäfer M, et al.
Cancers (Basel). 2021 Apr 7;13(8):1770. doi: 10.3390/cancers13081770.
Cancers (Basel). 2021.
PMID: 33917267
Free PMC article.
Review.
A treatment with the small molecule 5'-nitroindirubin-monoxime (INO) leads to inhibition of cyclin D1 and thus inhibition of proliferation. As a component of Danggui Longhui Wan, a traditional Chinese medicine, indirubins are used to treat chronic diseases and have …
A treatment with the small molecule 5'-nitroindirubin-monoxime (INO) leads to inhibition of cyclin D1 and thus inhibition of proliferation. …