NO-donor thiacarbocyanines as multifunctional agents for Alzheimer's disease.
Chegaev K, Federico A, Marini E, Rolando B, Fruttero R, Morbin M, Rossi G, Fugnanesi V, Bastone A, Salmona M, Badiola NB, Gasparini L, Cocco S, Ripoli C, Grassi C, Gasco A.
Chegaev K, et al.
Bioorg Med Chem. 2015 Aug 1;23(15):4688-4698. doi: 10.1016/j.bmc.2015.05.050. Epub 2015 Jun 3.
Bioorg Med Chem. 2015.
PMID: 26078011
Free article.
Some symmetrical and unsymmetrical thiacarbocyanines bearing NO-donor nitrooxy and furoxan moieties were synthesized and studied as candidate anti-Alzheimer's drugs. All products activated soluble guanylate cyclase (sGC) in a dose-dependent manner, depending on the presenc …
Some symmetrical and unsymmetrical thiacarbocyanines bearing NO-donor nitrooxy and furoxan moieties were synthesized and studied as candi …