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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1953 1
1973 1
1975 1
1976 1
1978 2
1979 5
1980 6
1981 4
1982 4
1983 3
1984 2
1985 1
1986 2
1987 4
1988 6
1989 3
1990 3
1991 4
1992 5
1993 3
1994 5
1995 6
1996 10
1997 7
1998 10
1999 8
2000 13
2001 44
2002 219
2003 768
2004 1902
2005 2986
2006 3904
2007 4888
2008 5624
2009 6432
2010 6909
2011 7487
2012 8147
2013 8451
2014 8094
2015 8033
2016 7193
2017 6851
2018 7061
2019 6507
2020 5537
2021 4887
2022 4249
2023 3422
2024 1367

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106,381 results

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The following term was not found in PubMed: 20Feng
Page 1
siRNA vs. shRNA: similarities and differences.
Rao DD, Vorhies JS, Senzer N, Nemunaitis J. Rao DD, et al. Adv Drug Deliv Rev. 2009 Jul 25;61(9):746-59. doi: 10.1016/j.addr.2009.04.004. Epub 2009 Apr 20. Adv Drug Deliv Rev. 2009. PMID: 19389436 Review.
Using available technology and bioinformatics investigators will soon be able to identify relevant bio molecular tumor network hubs as potential key targets for knockdown approaches. Methods of mediating the RNAi effect involve small interfering RNA (siRNA), …
Using available technology and bioinformatics investigators will soon be able to identify relevant bio molecular tumor network hubs as poten …
Short hairpin RNA (shRNA): design, delivery, and assessment of gene knockdown.
Moore CB, Guthrie EH, Huang MT, Taxman DJ. Moore CB, et al. Methods Mol Biol. 2010;629:141-58. doi: 10.1007/978-1-60761-657-3_10. Methods Mol Biol. 2010. PMID: 20387148 Free PMC article.
This included designing better methods for the successful delivery of small interfering RNAs (siRNAs) and short hairpin RNAs (shRNAs) into mammalian cells. ...Here we describe some well-tested protocols which should increase the chances of successful design, …
This included designing better methods for the successful delivery of small interfering RNAs (siRNAs) and short hairpin RNAs ( …
siRNA, miRNA, and shRNA: in vivo applications.
Pushparaj PN, Aarthi JJ, Manikandan J, Kumar SD. Pushparaj PN, et al. J Dent Res. 2008 Nov;87(11):992-1003. doi: 10.1177/154405910808701109. J Dent Res. 2008. PMID: 18946005 Review.
Subsequent RNAi studies have demonstrated the clinical potential of synthetic small interfering RNAs (siRNAs) or short hairpin RNAs (shRNAs) in dental diseases, eye diseases, cancer, metabolic diseases, neurodegenerative disorders, and other illnesses. siRNAs …
Subsequent RNAi studies have demonstrated the clinical potential of synthetic small interfering RNAs (siRNAs) or short hairpin …
A streamlined method for the design and cloning of shRNAs into an optimized Dox-inducible lentiviral vector.
Frank SB, Schulz VV, Miranti CK. Frank SB, et al. BMC Biotechnol. 2017 Feb 28;17(1):24. doi: 10.1186/s12896-017-0341-x. BMC Biotechnol. 2017. PMID: 28245848 Free PMC article.
BACKGROUND: Short hairpin RNA (shRNA) is an established and effective tool for stable knock down of gene expression. ...Lastly, we display the robustness of the system with a doxycycline titration and recovery time course and provide a cost/benefit analysis comparin …
BACKGROUND: Short hairpin RNA (shRNA) is an established and effective tool for stable knock down of gene expression. ...Lastly …
The recent progresses in shRNA-nanoparticle conjugate as a therapeutic approach.
Acharya R. Acharya R. Mater Sci Eng C Mater Biol Appl. 2019 Nov;104:109928. doi: 10.1016/j.msec.2019.109928. Epub 2019 Jun 27. Mater Sci Eng C Mater Biol Appl. 2019. PMID: 31500065 Review.
The recent trend of gene therapy is using short hairpin RNA conjugated with different types of nanoparticles. shRNAs have a significant role in gene silencing and have a promising role in treating several genetic and infectious diseases. There are several drawbacks …
The recent trend of gene therapy is using short hairpin RNA conjugated with different types of nanoparticles. shRNAs have a si …
A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen.
Moffat J, Grueneberg DA, Yang X, Kim SY, Kloepfer AM, Hinkle G, Piqani B, Eisenhaure TM, Luo B, Grenier JK, Carpenter AE, Foo SY, Stewart SA, Stockwell BR, Hacohen N, Hahn WC, Lander ES, Sabatini DM, Root DE. Moffat J, et al. Cell. 2006 Mar 24;124(6):1283-98. doi: 10.1016/j.cell.2006.01.040. Cell. 2006. PMID: 16564017 Free article.
To enable arrayed or pooled loss-of-function screens in a wide range of mammalian cell types, including primary and nondividing cells, we are developing lentiviral short hairpin RNA (shRNA) libraries targeting the human and murine genomes. The libraries currently co …
To enable arrayed or pooled loss-of-function screens in a wide range of mammalian cell types, including primary and nondividing cells, we ar …
shRNA-armed conditionally replicative adenoviruses: a promising approach for cancer therapy.
Zhang J, Ding M, Xu K, Mao L, Zheng J. Zhang J, et al. Oncotarget. 2016 May 17;7(20):29824-34. doi: 10.18632/oncotarget.8035. Oncotarget. 2016. PMID: 26980708 Free PMC article. Review.
The small-interfering RNAs (siRNAs) have been employed to knockdown the expression of cancer-associated genes and shown some promise in cancer therapy. ...In this review, we summarize recent progress in the development of CRAds-shRNA for cancer treatment. Com …
The small-interfering RNAs (siRNAs) have been employed to knockdown the expression of cancer-associated genes and shown some p …
RNA interference (RNAi)-based therapeutics for treatment of rare neurologic diseases.
Germain ND, Chung WK, Sarmiere PD. Germain ND, et al. Mol Aspects Med. 2023 Jun;91:101148. doi: 10.1016/j.mam.2022.101148. Epub 2022 Oct 17. Mol Aspects Med. 2023. PMID: 36257857 Review.
Understanding the fundamental causes of rare monogenic disorders has made gene therapy a possible treatment approach for these conditions. RNA interference (RNAi) technologies such as small interfering RNA (siRNA), microRNA (miRNA), and short hairpin …
Understanding the fundamental causes of rare monogenic disorders has made gene therapy a possible treatment approach for these conditions. …
Guidelines for the optimal design of miRNA-based shRNAs.
Bofill-De Ros X, Gu S. Bofill-De Ros X, et al. Methods. 2016 Jul 1;103:157-66. doi: 10.1016/j.ymeth.2016.04.003. Epub 2016 Apr 12. Methods. 2016. PMID: 27083402 Free PMC article. Review.
It can be triggered by transfected synthetic small interfering RNA (siRNA) or by expressed small hairpin RNA (shRNA). ...Here, based on current understanding of the miRNA maturation pathway, we discuss the principles of different shRNA …
It can be triggered by transfected synthetic small interfering RNA (siRNA) or by expressed small hairpin RNA …
Enzymatic construction of shRNA library from oligonucleotide library.
Park SK, Kee Y, Ryu T, Kim H, Hwang BJ. Park SK, et al. Genes Genomics. 2019 May;41(5):573-581. doi: 10.1007/s13258-019-00800-2. Epub 2019 Mar 4. Genes Genomics. 2019. PMID: 30830681
BACKGROUND: Short hairpin RNAs (shRNAs) expressed from vectors have been used as an effective means of exploiting the RNA interference (RNAi) pathway in mammalian cells. Genome-scale screening with shRNA libraries has been used to investigate the relationship …
BACKGROUND: Short hairpin RNAs (shRNAs) expressed from vectors have been used as an effective means of exploiting the RNA inte …
106,381 results
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