Similar articles for PMID: 22053050

Year	Number of Results
2008	3
2009	2
2010	2
2011	8
2012	9
2013	10
2014	14
2015	13
2016	11
2017	10
2018	5
2019	5
2020	10
2021	3
2022	2
2023	3
2024	0

1

mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase.

Zoncu R, Bar-Peled L, Efeyan A, Wang S, Sancak Y, Sabatini DM. Zoncu R, et al. Science. 2011 Nov 4;334(6056):678-83. doi: 10.1126/science.1207056. Science. 2011. PMID: 22053050 Free PMC article.

2

The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids.

Hoxhaj G, Caddye E, Najafov A, Houde VP, Johnson C, Dissanayake K, Toth R, Campbell DG, Prescott AR, MacKintosh C. Hoxhaj G, et al. Elife. 2016 Apr 22;5:e12278. doi: 10.7554/eLife.12278. Elife. 2016. PMID: 27244671 Free PMC article.

3

Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1.

Bar-Peled L, Schweitzer LD, Zoncu R, Sabatini DM. Bar-Peled L, et al. Cell. 2012 Sep 14;150(6):1196-208. doi: 10.1016/j.cell.2012.07.032. Cell. 2012. PMID: 22980980 Free PMC article.

4

Amino Acid Availability Modulates Vacuolar H+-ATPase Assembly.

Stransky LA, Forgac M. Stransky LA, et al. J Biol Chem. 2015 Nov 6;290(45):27360-27369. doi: 10.1074/jbc.M115.659128. Epub 2015 Sep 16. J Biol Chem. 2015. PMID: 26378229 Free PMC article.

5

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.

Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM. Sancak Y, et al. Cell. 2010 Apr 16;141(2):290-303. doi: 10.1016/j.cell.2010.02.024. Epub 2010 Apr 8. Cell. 2010. PMID: 20381137 Free PMC article.

6

Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes.

Ögmundsdóttir MH, Heublein S, Kazi S, Reynolds B, Visvalingam SM, Shaw MK, Goberdhan DC. Ögmundsdóttir MH, et al. PLoS One. 2012;7(5):e36616. doi: 10.1371/journal.pone.0036616. Epub 2012 May 4. PLoS One. 2012. PMID: 22574197 Free PMC article.

7

Amino acid signalling upstream of mTOR.

Jewell JL, Russell RC, Guan KL. Jewell JL, et al. Nat Rev Mol Cell Biol. 2013 Mar;14(3):133-9. doi: 10.1038/nrm3522. Epub 2013 Jan 30. Nat Rev Mol Cell Biol. 2013. PMID: 23361334 Free PMC article. Review.

8

Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9.

Jung J, Genau HM, Behrends C. Jung J, et al. Mol Cell Biol. 2015 Jul;35(14):2479-94. doi: 10.1128/MCB.00125-15. Epub 2015 May 11. Mol Cell Biol. 2015. PMID: 25963655 Free PMC article.

9

Orexin/hypocretin activates mTOR complex 1 (mTORC1) via an Erk/Akt-independent and calcium-stimulated lysosome v-ATPase pathway.

Wang Z, Liu S, Kakizaki M, Hirose Y, Ishikawa Y, Funato H, Yanagisawa M, Yu Y, Liu Q. Wang Z, et al. J Biol Chem. 2014 Nov 14;289(46):31950-31959. doi: 10.1074/jbc.M114.600015. Epub 2014 Oct 2. J Biol Chem. 2014. PMID: 25278019 Free PMC article.

10

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.

Rebsamen M, Pochini L, Stasyk T, de Araújo ME, Galluccio M, Kandasamy RK, Snijder B, Fauster A, Rudashevskaya EL, Bruckner M, Scorzoni S, Filipek PA, Huber KV, Bigenzahn JW, Heinz LX, Kraft C, Bennett KL, Indiveri C, Huber LA, Superti-Furga G. Rebsamen M, et al. Nature. 2015 Mar 26;519(7544):477-81. doi: 10.1038/nature14107. Epub 2015 Jan 7. Nature. 2015. PMID: 25561175 Free PMC article.

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