Similar articles for PMID: 27245636

Year	Number of Results
1993	1
2011	5
2012	10
2013	9
2014	12
2015	9
2016	27
2017	30
2018	35
2019	42
2020	38
2021	72
2022	117
2023	42
2024	0

1

The most prevalent genetic cause of ALS-FTD, C9orf72 synergizes the toxicity of ATXN2 intermediate polyglutamine repeats through the autophagy pathway.

Ciura S, Sellier C, Campanari ML, Charlet-Berguerand N, Kabashi E. Ciura S, et al. Autophagy. 2016 Aug 2;12(8):1406-8. doi: 10.1080/15548627.2016.1189070. Epub 2016 May 31. Autophagy. 2016. PMID: 27245636 Free PMC article.

2

C9ORF72 is a GDP/GTP exchange factor for Rab8 and Rab39 and regulates autophagy.

Corbier C, Sellier C. Corbier C, et al. Small GTPases. 2017 Jul 3;8(3):181-186. doi: 10.1080/21541248.2016.1212688. Epub 2016 Aug 5. Small GTPases. 2017. PMID: 27494456 Free PMC article. Review.

3

Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death.

Sellier C, Campanari ML, Julie Corbier C, Gaucherot A, Kolb-Cheynel I, Oulad-Abdelghani M, Ruffenach F, Page A, Ciura S, Kabashi E, Charlet-Berguerand N. Sellier C, et al. EMBO J. 2016 Jun 15;35(12):1276-97. doi: 10.15252/embj.201593350. Epub 2016 Apr 21. EMBO J. 2016. PMID: 27103069 Free PMC article.

4

C9orf72 ALS-FTD: recent evidence for dysregulation of the autophagy-lysosome pathway at multiple levels.

Beckers J, Tharkeshwar AK, Van Damme P. Beckers J, et al. Autophagy. 2021 Nov;17(11):3306-3322. doi: 10.1080/15548627.2021.1872189. Epub 2021 Feb 26. Autophagy. 2021. PMID: 33632058 Free PMC article. Review.

5

OPTN p.Met468Arg and ATXN2 intermediate length polyQ extension in families with C9orf72 mediated amyotrophic lateral sclerosis and frontotemporal dementia.

Farhan SMK, Gendron TF, Petrucelli L, Hegele RA, Strong MJ. Farhan SMK, et al. Am J Med Genet B Neuropsychiatr Genet. 2018 Jan;177(1):75-85. doi: 10.1002/ajmg.b.32606. Epub 2017 Oct 28. Am J Med Genet B Neuropsychiatr Genet. 2018. PMID: 29080331

6

Stable transgenic C9orf72 zebrafish model key aspects of the ALS/FTD phenotype and reveal novel pathological features.

Shaw MP, Higginbottom A, McGown A, Castelli LM, James E, Hautbergue GM, Shaw PJ, Ramesh TM. Shaw MP, et al. Acta Neuropathol Commun. 2018 Nov 19;6(1):125. doi: 10.1186/s40478-018-0629-7. Acta Neuropathol Commun. 2018. PMID: 30454072 Free PMC article.

7

The progress in C9orf72 research: ALS/FTD pathogenesis, functions and structure.

Jiang L, Zhang T, Lu K, Qi S. Jiang L, et al. Small GTPases. 2022 Jan;13(1):56-76. doi: 10.1080/21541248.2021.1892443. Epub 2021 Mar 5. Small GTPases. 2022. PMID: 33663328 Free PMC article. Review.

8

A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy.

Yang M, Liang C, Swaminathan K, Herrlinger S, Lai F, Shiekhattar R, Chen JF. Yang M, et al. Sci Adv. 2016 Sep 2;2(9):e1601167. doi: 10.1126/sciadv.1601167. eCollection 2016 Sep. Sci Adv. 2016. PMID: 27617292 Free PMC article.

9

Contribution of ATXN2 intermediary polyQ expansions in a spectrum of neurodegenerative disorders.

Lattante S, Millecamps S, Stevanin G, Rivaud-Péchoux S, Moigneu C, Camuzat A, Da Barroca S, Mundwiller E, Couarch P, Salachas F, Hannequin D, Meininger V, Pasquier F, Seilhean D, Couratier P, Danel-Brunaud V, Bonnet AM, Tranchant C, LeGuern E, Brice A, Le Ber I, Kabashi E; French Research Network on FTD and FTD-ALS. Lattante S, et al. Neurology. 2014 Sep 9;83(11):990-5. doi: 10.1212/WNL.0000000000000778. Epub 2014 Aug 6. Neurology. 2014. PMID: 25098532 Free PMC article.

10

Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72.

Zhu Q, Jiang J, Gendron TF, McAlonis-Downes M, Jiang L, Taylor A, Diaz Garcia S, Ghosh Dastidar S, Rodriguez MJ, King P, Zhang Y, La Spada AR, Xu H, Petrucelli L, Ravits J, Da Cruz S, Lagier-Tourenne C, Cleveland DW. Zhu Q, et al. Nat Neurosci. 2020 May;23(5):615-624. doi: 10.1038/s41593-020-0619-5. Epub 2020 Apr 13. Nat Neurosci. 2020. PMID: 32284607 Free PMC article.

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