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15041700,15758010,22359215,20428822,25434389,16609952,23662801,21365007,25723791,25105699,20686820,25655102,22034964,26682634,26883115,26113646,25910840,19514084,20032445,23377829,18082451,22975219,20167086,22065199,25400033,22414280,20585787,18945611,37047153,23328811,28516344,25078279,33661424,23715499,23245659,33710615,18757334,20232102,18004504,30717206,21107199,27921166,31804140,27428890,21968944,24519517,27997874,30514777,17721049,29726772,19269895,18445844,31701343,21472719,19536096,15297393,28266716,31422371,20150365,31754832,20372840,33663593,27733166,21789683,24101040,25233099,23443801,26320189,20861061,23553268,25163906,23479134,18687982,26423801,21075779,19695438,19635193,27025857,21425258,19834398,24420923,16954518,25394859,28097324,28682902,26249244,22614944,22214427,21097691,17024124,16983109,28298550,21177338,22674304,24248532,25663202,21331613,35474499,29678708,22307805,27764705,22517399,33113214,29425743,15332332,34467991,29159183,21059509,20388697,33203454,20628383,17700563,31108342,31325903,11070098,36513631,24990698,33684406,23175182,34378977,19506159,12744471,32748120,20935218,30537486,20820873,22127356,24670608,25031012,31488360,33116181,22877848,22274924,21339192,22990979,18772354,32367437,24395350,18795231,19221171,19996271,30782343,33771703,21311951,35180887,17404084,21910919,18317694,20725792,31039537,33037945,25194640,18556773,32479605,18393779,20668043,33001310,24190580,20603410,33984151,31831026,31413318,21747120,18403492,32070670,19741564,23224642,21156036,28409559,26603354,35018664,28371907,19075262,9850030,36376167,18632623,35275197,32417407,19118063,33535955,17938272,21636865,23686298,31121035,34182476,28039367,19846904,24157870,22244911,31175579,24057885,18091318,19841864,22045118,24526307,32010632,25558448,18676759,22241957,24130262,34610309,20068091,20353279,36970171,21181234,23680820,31094363,35045869,23086436,22665686,35671254,31288238,10404096,31325144,35122621,21844505,21269507,23115159,35469666,34496417,35858227,20530668,25869098,19367283,27143410,31964274,23514245,23624749,24109190,11870526,20589656,32027343,36705923,33236861,24554053,17342095,26137013,22986464,31054101,37092563,22970054,35626029,32578964,14985452,22437507,35453150,31478117,30786916,16565851,24367102,31766430,20803286,29973405,30511935,36009577,34206775,35452002,34988453,16292171,36291588,29618055,25193022,21882183,29515653,29061781,35804921,19335893,23977117,37078100,28903131,31386024,19884580,32328662,22980038,33689536,23685934,25516857,35378463,32164575,12815001,25499534,19179423,20717836,8612308,29285383,26150933,7523853,34771583,20676728,20306105,21173573,33673490,19584161,29963232,35974468,32942564,23946891,15494421,21301914,15029256,36523794,23066447,34744391,21410456,31828428,31068075,35522273,27643594,30857221,32867455,25096799,32477929,20822523,33754151,35258987,18556768,33121351,31783653,31373686,32039032,32354046,36504469,35589662,35648484,32307112,20449628,23320456,27845303,32133779,32075134,36604366,18618580,23460078,15063138,24163400,29381964,36902848,19267105,33546098,33041828,28672945,31256047,22472174,32233996,34976195,34171601,30083233,23136592,31717973,18493996,36092918,33552543,21863242,32777076,26131285,32766140,30647912,26885283,36547486,24086261,31036078,35088051,28660172,29606808,29020502,23250732,29434855,34347098,33500356,35765521,33937035,34244774,24319345,32886104,32139182,18408892,34424912,36789113,31687638,33718145,27073563,28003765,36428615,23543729,33062270,34321837,36284931,33074333,34982371,33194592,18516257,33850305,30583528,22270850,36050369,25061500,32407064,36900177,29594237,36198483,25026297,24466377,24202340,34827559,27330789,23346075,35261976,33123485,28805815,34566423,33014392,35806160,32083011,32005270,33216844,30947475,30899304,29333122,34309720,23386096,26251808,34204877,35928314,28854621,22815729,32684859,16554488,31044184,31386084,35629107,36948276,34901858,29016865,35379142,23275590,35117137,36185858,33547324,37083881,34966669,30108945,27308637,30151353,27462603,35973053,30326653,34850193,31206012,36412091,34258581,36590948,36299794,35817776,34244800,33880446,33395481,27802852,32239234,32027348,32109287,34150184,31644123,34469495,29905806,34359043,36970166[uid]

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466 results

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Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide.

Hegi ME, Diserens AC, Godard S, Dietrich PY, Regli L, Ostermann S, Otten P, Van Melle G, de Tribolet N, Stupp R. Hegi ME, et al. Clin Cancer Res. 2004 Mar 15;10(6):1871-4. doi: 10.1158/1078-0432.ccr-03-0384. Clin Cancer Res. 2004. PMID: 15041700 Clinical Trial.

MGMT gene silencing and benefit from temozolomide in glioblastoma.

Hegi ME, Diserens AC, Gorlia T, Hamou MF, de Tribolet N, Weller M, Kros JM, Hainfellner JA, Mason W, Mariani L, Bromberg JE, Hau P, Mirimanoff RO, Cairncross JG, Janzer RC, Stupp R. Hegi ME, et al. N Engl J Med. 2005 Mar 10;352(10):997-1003. doi: 10.1056/NEJMoa043331. N Engl J Med. 2005. PMID: 15758010 Free article.

O(6) -methylguanine-DNA methyltransferase (MGMT) promoter methylation and low MGMT-encoded protein expression as prognostic markers in glioblastoma patients treated with biodegradable carmustine wafer implants after initial surgery followed by radiotherapy with concomitant and adjuvant temozolomide.

Lechapt-Zalcman E, Levallet G, Dugué AE, Vital A, Diebold MD, Menei P, Colin P, Peruzzy P, Emery E, Bernaudin M, Chapon F, Guillamo JS. Lechapt-Zalcman E, et al. Cancer. 2012 Sep 15;118(18):4545-54. doi: 10.1002/cncr.27441. Epub 2012 Feb 22. Cancer. 2012. PMID: 22359215 Free article.

Prognostic value of MGMT promoter methylation in glioblastoma patients treated with temozolomide-based chemoradiation: a Portuguese multicentre study.

Costa BM, Caeiro C, Guimarães I, Martinho O, Jaraquemada T, Augusto I, Castro L, Osório L, Linhares P, Honavar M, Resende M, Braga F, Silva A, Pardal F, Amorim J, Nabiço R, Almeida R, Alegria C, Pires M, Pinheiro C, Carvalho E, Lopes JM, Costa P, Damasceno M, Reis RM. Costa BM, et al. Oncol Rep. 2010 Jun;23(6):1655-62. doi: 10.3892/or_00000808. Oncol Rep. 2010. PMID: 20428822 Free article.

Long-term therapy with temozolomide is a feasible option for newly diagnosed glioblastoma: a single-institution experience with as many as 101 temozolomide cycles.

Barbagallo GM, Paratore S, Caltabiano R, Palmucci S, Parra HS, Privitera G, Motta F, Lanzafame S, Scaglione G, Longo A, Albanese V, Certo F. Barbagallo GM, et al. Neurosurg Focus. 2014 Dec;37(6):E4. doi: 10.3171/2014.9.FOCUS14502. Neurosurg Focus. 2014. PMID: 25434389

MGMT promoter methylation correlates with survival benefit and sensitivity to temozolomide in pediatric glioblastoma.

Donson AM, Addo-Yobo SO, Handler MH, Gore L, Foreman NK. Donson AM, et al. Pediatr Blood Cancer. 2007 Apr;48(4):403-7. doi: 10.1002/pbc.20803. Pediatr Blood Cancer. 2007. PMID: 16609952

MGMT promoter methylation status and prognosis of patients with primary or recurrent glioblastoma treated with carmustine wafers.

Gutenberg A, Bock HC, Brück W, Doerner L, Mehdorn HM, Roggendorf W, Westphal M, Felsberg J, Reifenberger G, Giese A. Gutenberg A, et al. Br J Neurosurg. 2013 Dec;27(6):772-8. doi: 10.3109/02688697.2013.791664. Epub 2013 May 11. Br J Neurosurg. 2013. PMID: 23662801 Clinical Trial.

O-methylguanine-DNA methyltransferase (MGMT) mRNA expression predicts outcome in malignant glioma independent of MGMT promoter methylation.

Kreth S, Thon N, Eigenbrod S, Lutz J, Ledderose C, Egensperger R, Tonn JC, Kretzschmar HA, Hinske LC, Kreth FW. Kreth S, et al. PLoS One. 2011 Feb 18;6(2):e17156. doi: 10.1371/journal.pone.0017156. PLoS One. 2011. PMID: 21365007 Free PMC article.

Prognostic value of MGMT promoter status in non-resectable glioblastoma after adjuvant therapy.

Iaccarino C, Orlandi E, Ruggeri F, Nicoli D, Torricelli F, Maggi M, Cerasti D, Pisanello A, Pedrazzi G, Froio E, Crafa P, D'Abbiero N, Michiara M, Ghadirpour R, Servadei F. Iaccarino C, et al. Clin Neurol Neurosurg. 2015 May;132:1-8. doi: 10.1016/j.clineuro.2015.01.029. Epub 2015 Feb 7. Clin Neurol Neurosurg. 2015. PMID: 25723791

Is the absolute value of O(6)-methylguanine-DNA methyltransferase gene messenger RNA a prognostic factor, and does it predict the results of treatment of glioblastoma with temozolomide?

Tanaka S, Akimoto J, Narita Y, Oka H, Tashiro T. Tanaka S, et al. J Neurosurg. 2014 Oct;121(4):818-26. doi: 10.3171/2014.6.JNS132535. Epub 2014 Aug 8. J Neurosurg. 2014. PMID: 25105699

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