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16794006,27150391,24675665,25070550,18666258,18406350,22683370,15118091,22593575,15166014,22580899,15741654,23690465,22176652,28546220,25913303,21273557,19930098,20649626,34118252,17461796,18280815,26980204,22019884,15358785,19060325,15805190,22261195,19008317,18039658,24632287,23333725,23400816,25544176,25258384,18836590,25778403,8941642,23714205,17452316,21539517,15677715,31419281,25613181,20026049,18245819,16211558,26833058,18675252,32913121,17449864,23308045,28750079,29396908,18355829,15767856,20884874,26056005,26547624,25341796,25463543,20529551,25110901,26494228,15385538,22074827,31553664,25023731,25940973,26350813,22848640,17493938,32078365,26323289,25940972,16806138,26333678,25600226,16893422,17242417,25519174,17328821,25682035,33119548,26548330,10024503,20562239,22992388,23422832,20448210,26252194,18197702,24603306,21069265,21332221,14583618,21692990,24548670,9788969,26342106,19191301,26668321,17495605,24680982,33276863,18649882,18354138,23087140,23974119,36263780,25791168,29428206,25652089,17435765,32705598,22554600,30026278,24144304,27986651,26824363,22426206,17080197,19601924,32673528,20498851,31004037,30767742,25904765,19828345,25410128,28204827,22005270,11352738,24950000,29548750,29180444,19878649,19443683,16487721,33531418,18638454,16407292,15772090,24352472,19222187,26023080,28673045,29183623,17765244,18799458,26987067,31867167,24166456,24134510,27470509,20073037,36077166,21411093,30582457,29618348,17502100,25349780,28495363,19628659,20453200,19635789,32769621,33020528,19265033,19269636,29569973,35344222,17502126,12730697,19489072,23283366,28145001,24916110,19224862,27552305,26495026,21518694,24308640,30092639,20716520,32423823,29601818,27358438,29665987,16913836,28012395,36475702,15099351,30002483,27082100,22051553,27031271,17448444,36207148,24893659,31055921,27038318,27617748,28196290,18617647,16741291,27707816,36193893,33758009,24619822,34615375,29982592,34816633,25889684,27230129,25887680,35660019,15297286,21596380,30768966,12220520,25320235,22481440,30235833,16462892,20178985,35263196,27171436,12007578,19273907,34593126,36209894,33153264,26445568,18498363,29113347,36771126,36353989,32613143,30066942,21494143,28304296,29727700,29438441,27121620,24677271,20028367,30100244,33609572,28115413,25967607,27751895,15297287,25026302,27663646,7515194,26978583,19592617,36243100,32058941,31317882,11546779,31843964,31870234,15001574,11108739,31452340,27050512,24735884,29467219,28000893,27405064,28179493,29050560,25931382,16957181,17353672,35007650,36230934,34731223,23376223,31934720,34036816,22606049,17870468,34666623,16384559,26354227,30483910,30015940,16423404,27578139,15581455,36357523,27424515,33606190,23580231,22658144,22573014,27019638,19188430,11445560,30668438,34015522,33739075,36913119,33609733,34439528,35154499,31778654,27318830,11238273,18054320,33737240,36103516,28504688,36552895,26320603,29050561,18375913,30443213,36125039,23426179,33639994,27809445,30844857,28377633,30253291,23300532,27092942,25255477,7925422,35883473,32674159,33070710,28089936,29294034,27995077,24753547,29308438,36356495,33617869,10985956,36980993,17681148,33590771,26131194,28301372,30335889,27057980,18388699,22398276,24811296,35237981,36830035,30372828,31921471,22260066,34884827,35038435,23406852,35408655,31785104,34994492,1816553,35560019,29378408,2906935,31784031,15471862,32680936,16376325,3471147,36708961,25857370,34859075,36180774,34895256,27378433,36557234,35323669,23997648,28341860,9434055,27340263,32824248,31462089,29404461,28291840,34966782,12552133,33519890,9248728,7919660,34307504,29174841,11481320,10655497,27986868,36097119,25349778,32949971,23307490,34924503,27041125,32014013,23469003,24252756,34631822,32067608,29046503,18041677,31978056,31505607,32614936,29507367,28821605[uid]

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Fasting induces hyperlipidemia in mice overexpressing proprotein convertase subtilisin kexin type 9: lack of modulation of very-low-density lipoprotein hepatic output by the low-density lipoprotein receptor.

Lambert G, Jarnoux AL, Pineau T, Pape O, Chetiveaux M, Laboisse C, Krempf M, Costet P. Lambert G, et al. Endocrinology. 2006 Oct;147(10):4985-95. doi: 10.1210/en.2006-0098. Epub 2006 Jun 22. Endocrinology. 2006. PMID: 16794006

Low-Density Lipoprotein Receptor-Dependent and Low-Density Lipoprotein Receptor-Independent Mechanisms of Cyclosporin A-Induced Dyslipidemia.

Kockx M, Glaros E, Leung B, Ng TW, Berbée JF, Deswaerte V, Nawara D, Quinn C, Rye KA, Jessup W, Rensen PC, Meikle PJ, Kritharides L. Kockx M, et al. Arterioscler Thromb Vasc Biol. 2016 Jul;36(7):1338-49. doi: 10.1161/ATVBAHA.115.307030. Epub 2016 May 5. Arterioscler Thromb Vasc Biol. 2016. PMID: 27150391

Hepatic overexpression of idol increases circulating protein convertase subtilisin/kexin type 9 in mice and hamsters via dual mechanisms: sterol regulatory element-binding protein 2 and low-density lipoprotein receptor-dependent pathways.

Sasaki M, Terao Y, Ayaori M, Uto-Kondo H, Iizuka M, Yogo M, Hagisawa K, Takiguchi S, Yakushiji E, Nakaya K, Ogura M, Komatsu T, Ikewaki K. Sasaki M, et al. Arterioscler Thromb Vasc Biol. 2014 Jun;34(6):1171-8. doi: 10.1161/ATVBAHA.113.302670. Epub 2014 Mar 27. Arterioscler Thromb Vasc Biol. 2014. PMID: 24675665

Proprotein convertase subtilisin kexin type 9 promotes intestinal overproduction of triglyceride-rich apolipoprotein B lipoproteins through both low-density lipoprotein receptor-dependent and -independent mechanisms.

Rashid S, Tavori H, Brown PE, Linton MF, He J, Giunzioni I, Fazio S. Rashid S, et al. Circulation. 2014 Jul 29;130(5):431-41. doi: 10.1161/CIRCULATIONAHA.113.006720. Epub 2014 May 23. Circulation. 2014. PMID: 25070550 Free PMC article.

Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration.

Zaid A, Roubtsova A, Essalmani R, Marcinkiewicz J, Chamberland A, Hamelin J, Tremblay M, Jacques H, Jin W, Davignon J, Seidah NG, Prat A. Zaid A, et al. Hepatology. 2008 Aug;48(2):646-54. doi: 10.1002/hep.22354. Hepatology. 2008. PMID: 18666258

Secreted proprotein convertase subtilisin/kexin type 9 reduces both hepatic and extrahepatic low-density lipoprotein receptors in vivo.

Schmidt RJ, Beyer TP, Bensch WR, Qian YW, Lin A, Kowala M, Alborn WE, Konrad RJ, Cao G. Schmidt RJ, et al. Biochem Biophys Res Commun. 2008 Jun 13;370(4):634-40. doi: 10.1016/j.bbrc.2008.04.004. Epub 2008 Apr 10. Biochem Biophys Res Commun. 2008. PMID: 18406350

Serum levels of proprotein convertase subtilisin/kexin type 9 in subjects with familial hypercholesterolemia indicate that proprotein convertase subtilisin/kexin type 9 is cleared from plasma by low-density lipoprotein receptor-independent pathways.

Cameron J, Bogsrud MP, Tveten K, Strøm TB, Holven K, Berge KE, Leren TP. Cameron J, et al. Transl Res. 2012 Aug;160(2):125-30. doi: 10.1016/j.trsl.2012.01.010. Epub 2012 Jan 31. Transl Res. 2012. PMID: 22683370

Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype.

Maxwell KN, Breslow JL. Maxwell KN, et al. Proc Natl Acad Sci U S A. 2004 May 4;101(18):7100-5. doi: 10.1073/pnas.0402133101. Epub 2004 Apr 26. Proc Natl Acad Sci U S A. 2004. PMID: 15118091 Free PMC article.

Peroxisome Proliferator-activated receptor γ activation by ligands and dephosphorylation induces proprotein convertase subtilisin kexin type 9 and low density lipoprotein receptor expression.

Duan Y, Chen Y, Hu W, Li X, Yang X, Zhou X, Yin Z, Kong D, Yao Z, Hajjar DP, Liu L, Liu Q, Han J. Duan Y, et al. J Biol Chem. 2012 Jul 6;287(28):23667-77. doi: 10.1074/jbc.M112.350181. Epub 2012 May 16. J Biol Chem. 2012. PMID: 22593575 Free PMC article.

Apolipoprotein B100 metabolism in autosomal-dominant hypercholesterolemia related to mutations in PCSK9.

Ouguerram K, Chetiveaux M, Zair Y, Costet P, Abifadel M, Varret M, Boileau C, Magot T, Krempf M. Ouguerram K, et al. Arterioscler Thromb Vasc Biol. 2004 Aug;24(8):1448-53. doi: 10.1161/01.ATV.0000133684.77013.88. Epub 2004 May 27. Arterioscler Thromb Vasc Biol. 2004. PMID: 15166014

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