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Metabolic activation of N-hydroxy arylamines and N-hydroxy heterocyclic amines by human sulfotransferase(s).
Chou HC, Lang NP, Kadlubar FF. Chou HC, et al. Cancer Res. 1995 Feb 1;55(3):525-9. Cancer Res. 1995. PMID: 7834621
No ST-mediated DNA binding of N-hydroxy-2-amino-3-methylimidazo[4,5-f]quinoline or N-hydroxy-2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline was detected under our assay conditions. ...
No ST-mediated DNA binding of N-hydroxy-2-amino-3-methylimidazo[4,5-f]quinoline or N-hydroxy-2-amino-3, …
Bioactivation of the cooked food mutagen N-hydroxy-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by estrogen sulfotransferase in cultured human mammary epithelial cells.
Lewis AJ, Walle UK, King RS, Kadlubar FF, Falany CN, Walle T. Lewis AJ, et al. Carcinogenesis. 1998 Nov;19(11):2049-53. doi: 10.1093/carcin/19.11.2049. Carcinogenesis. 1998. PMID: 9855023
In contrast, EST did not catalyze the DNA binding of two other cooked food mutagens, N-hydroxy-2-amino-3-methylimidazo[4,5-f]quinoline and N-hydroxy-2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, which a …
In contrast, EST did not catalyze the DNA binding of two other cooked food mutagens, N-hydroxy-2-amino-3-methylimidazo[4,5-f]quinoline and …
Codominant expression of N-acetylation and O-acetylation activities catalyzed by N-acetyltransferase 2 in human hepatocytes.
Doll MA, Zang Y, Moeller T, Hein DW. Doll MA, et al. J Pharmacol Exp Ther. 2010 Aug;334(2):540-4. doi: 10.1124/jpet.110.168567. Epub 2010 Apr 29. J Pharmacol Exp Ther. 2010. PMID: 20430842 Free PMC article.

A robust and significant relationship was observed between deduced NAT2 phenotype (rapid, intermediate, or slow) and N-acetyltransferase activity toward sulfamethazine (p < 0.0001) and 4-aminobiphenyl (p < 0.0001) and for O-acetyltransferase-catalyzed metabolic activation o

…
A robust and significant relationship was observed between deduced NAT2 phenotype (rapid, intermediate, or slow) and N-acetyltransferase act …
The effect of the rs1799931 G857A (G286E) polymorphism on N-acetyltransferase 2-mediated carcinogen metabolism and genotoxicity differs with heterocyclic amine exposure.
Hein DW, Salazar-González RA, Doll MA, Zang Y. Hein DW, et al. Arch Toxicol. 2023 Oct;97(10):2697-2705. doi: 10.1007/s00204-023-03577-2. Epub 2023 Aug 18. Arch Toxicol. 2023. PMID: 37592049
The T341C (I114T) SNP reduced the O-acetylation of N-hydroxy-2-amino-3-methylimidazo [4,5-f] quinoline (N-OH-IQ), N-hydroxy-2-amino-3,8-dimethylimidazo [4,5-f] quinoxaline (N-OH-MeIQx) and N-hydroxy- 2-a …
The T341C (I114T) SNP reduced the O-acetylation of N-hydroxy-2-amino-3-methylimidazo [4,5-f] quinoline (N-OH-IQ), N-hydroxy- …
4-Aminobiphenyl downregulation of NAT2 acetylator genotype-dependent N- and O-acetylation of aromatic and heterocyclic amine carcinogens in primary mammary epithelial cell cultures from rapid and slow acetylator rats.
Jefferson FA, Xiao GH, Hein DW. Jefferson FA, et al. Toxicol Sci. 2009 Jan;107(1):293-7. doi: 10.1093/toxsci/kfn216. Epub 2008 Oct 8. Toxicol Sci. 2009. PMID: 18842621 Free PMC article.
PABA, 2-aminofluorene, and 4-aminobiphenyl N-acetyltransferase and N-hydroxy-2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine and N-hydroxy-2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline O-acetyltransfera …
PABA, 2-aminofluorene, and 4-aminobiphenyl N-acetyltransferase and N-hydroxy-2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine and N- …
Effects of single nucleotide polymorphisms in human N-acetyltransferase 2 on metabolic activation (O-acetylation) of heterocyclic amine carcinogens.
Hein DW, Fretland AJ, Doll MA. Hein DW, et al. Int J Cancer. 2006 Sep 1;119(5):1208-11. doi: 10.1002/ijc.21957. Int J Cancer. 2006. PMID: 16570281 Free PMC article.
N-Acetyltransferase 2 (NAT2) catalyzes the O-acetylation of N-hydroxy heterocyclic amines such as N-hydroxy-2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (N--OH--MeIQx) and N-hydroxy-2-amino-1-methyl-6-p …
N-Acetyltransferase 2 (NAT2) catalyzes the O-acetylation of N-hydroxy heterocyclic amines such as N-hydroxy-2-amino …