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1978 3
1979 7
1980 1
1981 2
1982 3
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1992 1
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2003 1
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Page 1
Effects of emorfazone on the nociceptive response induced by bradykinin in rats and dogs.
Sato M. Sato M. Arch Int Pharmacodyn Ther. 1982 Jun;257(2):200-12. Arch Int Pharmacodyn Ther. 1982. PMID: 6956248
Such mode of action of emorfazone on BK-induced nociception was confirmed with a similar experiment using conscious rats. These results suggest that the main site of anti-nociceptive action of emorfazone may be in the periphery, and that its action may be not due to …
Such mode of action of emorfazone on BK-induced nociception was confirmed with a similar experiment using conscious rats. These resul …
[Studies on pyridazinone derivatives. XVI. Analgesic-antiinflammatory activities of 3(2H)-pyridazinone derivatives].
Takaya M, Sato M. Takaya M, et al. Yakugaku Zasshi. 1994 Feb;114(2):94-110. doi: 10.1248/yakushi1947.114.2_94. Yakugaku Zasshi. 1994. PMID: 8169774 Japanese.
In order to examine analgesic and antiinflammatory activities of the position isomers of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (1, emorfazone), an analgesic-antiinflammatory drug, 5-ethoxy-2-methyl-4-morpholino-3(2H)-pyridazinone (2), 6-ethoxy-2-methyl-4-morpho …
In order to examine analgesic and antiinflammatory activities of the position isomers of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone ( …
Studies on mechanisms of action of emorfazone. Effects on the release of bradykinin-like substance in thermic edema of rat paws.
Sato M, Yamaguchi A. Sato M, et al. Arzneimittelforschung. 1982;32(4):379-82. Arzneimittelforschung. 1982. PMID: 7201806
Effects of 4-ethoxy-3-methyl-5-morpholino-3(2H)-pyridazinone (emorfazone, M 73101) on thermic edema in rats were investigated, and following results were obtained: Oral administration of emorfazone (100 and 200 mg/kg) significantly inhibited the edema formation resu …
Effects of 4-ethoxy-3-methyl-5-morpholino-3(2H)-pyridazinone (emorfazone, M 73101) on thermic edema in rats were investigated, and fo …
Analgesic action of amfenac Na, a non-steroidal anti-inflammatory agent.
Hiranuma T, Kato S, Hachisu M. Hiranuma T, et al. J Pharmacobiodyn. 1988 Sep;11(9):612-9. doi: 10.1248/bpb1978.11.612. J Pharmacobiodyn. 1988. PMID: 3265150
This effect was the most potent among the drugs used; the order of potency was as follows: amfenac Na greater than floctafenine greater than loxoprofen much greater than piroxicam = emorfazone greater than mefanamic acid. Similarly, the intravenous injection of amfenac Na …
This effect was the most potent among the drugs used; the order of potency was as follows: amfenac Na greater than floctafenine greater than …
Contribution of substance P to heat-induced edema in rat paw.
Yonehara N, Shibutani T, Inoki R. Yonehara N, et al. J Pharmacol Exp Ther. 1987 Sep;242(3):1071-6. J Pharmacol Exp Ther. 1987. PMID: 2443642
This increasing effect of SP on paw volume was more substantial than that produced by histamine. Simultaneous treatment with stem bromelain and emorfazone decreased significantly the heat-evoked iSP release and edema. ...
This increasing effect of SP on paw volume was more substantial than that produced by histamine. Simultaneous treatment with stem bromelain …
Changes of metabolism and substrate-binding spectrum of emorfazone between immature and mature guinea-pigs.
Hayashi T, Amino M, Ikoma Y. Hayashi T, et al. Xenobiotica. 1983 Aug;13(8):461-6. doi: 10.3109/00498258309052285. Xenobiotica. 1983. PMID: 6649679
Km values for oxidative metabolism at two types of carbon atoms adjacent to nitrogen and oxygen of the morpholino moiety of emorfazone (alpha- and beta-oxygenation) were 1.2 X 10(-2) and 3.0 X 10(-4)M in immature male guinea-pigs, and 8.6 X 10(-3) and 2.5 X 10(-4) M in mat …
Km values for oxidative metabolism at two types of carbon atoms adjacent to nitrogen and oxygen of the morpholino moiety of emorfazone …
4-Amino-3(2H)-pyridazinones bearing arylpiperazinylalkyl groups and related compounds: synthesis and antinociceptive activity.
Piaz VD, Vergelli C, Giovannoni MP, Scheideler MA, Petrone G, Zaratin P. Piaz VD, et al. Farmaco. 2003 Nov;58(11):1063-71. doi: 10.1016/S0014-827X(03)00162-9. Farmaco. 2003. PMID: 14572856
Subsequent dose-response studies revealed 12e to be almost 40-fold more potent than the structurally related Emorfazone....
Subsequent dose-response studies revealed 12e to be almost 40-fold more potent than the structurally related Emorfazone....
24 results