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Year Number of Results
1961 1
1963 1
1965 1
1973 1
1985 1
1988 1
1993 1
1994 2
1995 1
1999 1
2000 1
2002 1
2003 1
2004 1
2005 1
2007 1
2012 5
2013 1
2014 1
2015 1
2016 1
2017 2
2018 5
2019 1
2020 2
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2022 8
2024 1

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44 results

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Page 1
Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis.
Weindel CG, Martinez EL, Zhao X, Mabry CJ, Bell SL, Vail KJ, Coleman AK, VanPortfliet JJ, Zhao B, Wagner AR, Azam S, Scott HM, Li P, West AP, Karpac J, Patrick KL, Watson RO. Weindel CG, et al. Cell. 2022 Aug 18;185(17):3214-3231.e23. doi: 10.1016/j.cell.2022.06.038. Epub 2022 Jul 30. Cell. 2022. PMID: 35907404 Free PMC article.
We discovered that the disease-associated gain-of-function allele Lrrk2(G2019S) (leucine-rich repeat kinase 2) perturbs mitochondrial homeostasis and reprograms cell death pathways in macrophages. ...
We discovered that the disease-associated gain-of-function allele Lrrk2(G2019S) (leucine-rich repeat kinase 2) perturbs mitochondrial …
Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila.
Gu X, Jouandin P, Lalgudi PV, Binari R, Valenstein ML, Reid MA, Allen AE, Kamitaki N, Locasale JW, Perrimon N, Sabatini DM. Gu X, et al. Nature. 2022 Aug;608(7921):209-216. doi: 10.1038/s41586-022-04960-2. Epub 2022 Jul 20. Nature. 2022. PMID: 35859173 Free PMC article.
Knock-in flies expressing a leucine-binding-deficient Sestrin mutant (Sesn(L431E)) have reduced, leucine-insensitive mTORC1 activity. ...This preference depends on Sestrin and its capacity to bind leucine. Leucine regulates mTORC1 activity in glial cel …
Knock-in flies expressing a leucine-binding-deficient Sestrin mutant (Sesn(L431E)) have reduced, leucine-insensitive mTORC1 ac …
Deciphering the function of leucine-rich repeat kinase 2 and targeting its dysfunction in disease.
Lewis PA, Alessi DR. Lewis PA, et al. Biochem Soc Trans. 2012 Oct;40(5):1039-41. doi: 10.1042/BST20120178. Biochem Soc Trans. 2012. PMID: 22988861 Review.
LRRK2 (leucine-rich repeat kinase 2) is a gene of unknown function that has been linked to a number a human diseases, including PD (Parkinson's disease), IBD (inflammatory bowel disease), leprosy and cancer. ...
LRRK2 (leucine-rich repeat kinase 2) is a gene of unknown function that has been linked to a number a human diseases, including PD (P …
MptpA Kinetics Enhanced by Allosteric Control of an Active Conformation.
Maschietto F, Zavala E, Allen B, Loria JP, Batista V. Maschietto F, et al. J Mol Biol. 2022 Sep 15;434(17):167540. doi: 10.1016/j.jmb.2022.167540. Epub 2022 Mar 23. J Mol Biol. 2022. PMID: 35339563 Free PMC article.
Here, we combine computational modeling with solution NMR spectroscopy and we find that Q75 is an allosteric site. Removal of the polar side chain of Q75 by mutation to leucine results in a cascade of events that reposition the acid loop over the active site and relocates …
Here, we combine computational modeling with solution NMR spectroscopy and we find that Q75 is an allosteric site. Removal of the polar side …
A High-Throughput Candida albicans Two-Hybrid System.
Schoeters F, Munro CA, d'Enfert C, Van Dijck P. Schoeters F, et al. mSphere. 2018 Aug 22;3(4):e00391-18. doi: 10.1128/mSphere.00391-18. mSphere. 2018. PMID: 30135223 Free PMC article.
Candida albicans is a human fungal pathogen that does not follow the universal codon usage, as it translates the CUG codon into serine rather than leucine. This makes it difficult to study protein-protein interactions using the standard yeast two-hybrid (Y2H) system in the …
Candida albicans is a human fungal pathogen that does not follow the universal codon usage, as it translates the CUG codon into serine rathe …
MMP7 cleavage of amino-terminal CD95 death receptor switches signaling toward non-apoptotic pathways.
Kenji SF, Kurma K, Collet B, Oblet C, Debure L, Di Primo C, Minder L, Vérité F, Danger Y, Jean M, Penna A, Levoin N, Legembre P. Kenji SF, et al. Cell Death Dis. 2022 Oct 23;13(10):895. doi: 10.1038/s41419-022-05352-0. Cell Death Dis. 2022. PMID: 36274061 Free PMC article.
Although the mature CD95 membrane receptor is considered to start with the arginine at position 17 after elimination of the signal peptide, this receptor can also be cleaved by MMP7 upstream of its leucine at position 37. This post-translational modification occurs in canc …
Although the mature CD95 membrane receptor is considered to start with the arginine at position 17 after elimination of the signal peptide, …
Cryo-EM structure of transcription termination factor Rho from Mycobacterium tuberculosis reveals bicyclomycin resistance mechanism.
Saridakis E, Vishwakarma R, Lai-Kee-Him J, Martin K, Simon I, Cohen-Gonsaud M, Coste F, Bron P, Margeat E, Boudvillain M. Saridakis E, et al. Commun Biol. 2022 Feb 9;5(1):120. doi: 10.1038/s42003-022-03069-6. Commun Biol. 2022. PMID: 35140348 Free PMC article.
The (Mtb)Rho hexamer is poised into a pre-catalytic, open-ring state wherein specific contacts stabilize ATP in intersubunit ATPase pockets, thereby explaining the cofactor preference of (Mtb)Rho. We reveal a leucine-to-methionine substitution that creates a steric bulk in …
The (Mtb)Rho hexamer is poised into a pre-catalytic, open-ring state wherein specific contacts stabilize ATP in intersubunit ATPase pockets, …
44 results