Effects of propylene oxide exposure on rat nasal respiratory cell proliferation.
Ríos-Blanco MN, Yamaguchi S, Dhawan-Robl M, Kessler W, Schoonhoven R, Filser JG, Swenberg JA.
Ríos-Blanco MN, et al.
Toxicol Sci. 2003 Oct;75(2):279-88. doi: 10.1093/toxsci/kfg187. Epub 2003 Jul 11.
Toxicol Sci. 2003.
PMID: 12857943
Long-term exposure of rodents to propylene oxide (PO) induced inflammation, respiratory cell hyperplasia, and nasal tumors at concentrations >/= 300 ppm, suggesting a possible role for cytotoxicity and compensatory cell proliferation in PO carcinogenesis. ...
Long-term exposure of rodents to propylene oxide (PO) induced inflammation, respiratory cell hyperplasia, and nasal tumors at concent …