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2006 1
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Page 1
Improving immunity in the elderly: current and future lessons from nonhuman primate models.
Meyer C, Kerns A, Haberthur K, Messaoudi I. Meyer C, et al. Age (Dordr). 2012 Oct;34(5):1157-68. doi: 10.1007/s11357-011-9353-y. Epub 2011 Dec 20. Age (Dordr). 2012. PMID: 22180097 Free PMC article. Review.
Aging results in several structural and functional changes in the immune system, often described under the umbrella term "immune senescence". Age-related changes affect both the innate and adaptive arms of the immune system and are believed to result in increased susceptib …
Aging results in several structural and functional changes in the immune system, often described under the umbrella term "immune sene …
Contributions of humoral and cellular immunity to vaccine-induced protection in humans.
Amanna IJ, Slifka MK. Amanna IJ, et al. Virology. 2011 Mar 15;411(2):206-15. doi: 10.1016/j.virol.2010.12.016. Epub 2011 Jan 8. Virology. 2011. PMID: 21216425 Free PMC article. Review.
Vaccines play a vital role in protecting the host against infectious disease. The most effective licensed vaccines elicit long-term antigen-specific antibody responses by plasma cells in addition to the development of persisting T cell and B cell memory. ...
Vaccines play a vital role in protecting the host against infectious disease. The most effective licensed vaccines elicit long-term a …
Cloning of non-human primates: the road "less traveled by".
Sparman ML, Tachibana M, Mitalipov SM. Sparman ML, et al. Int J Dev Biol. 2010;54(11-12):1671-8. doi: 10.1387/ijdb.103196ms. Int J Dev Biol. 2010. PMID: 21404187 Free PMC article. Review.
Early studies on cloning of non-human primates by nuclear transfer utilized embryonic blastomeres from preimplantation embryos which resulted in the reproducible birth of live offspring. Soon after, the focus shifted to employing somatic cells as a source of donor nuclei ( …
Early studies on cloning of non-human primates by nuclear transfer utilized embryonic blastomeres from preimplantation embryos which resulte …
Perimenopausal regulation of steroidogenesis in the nonhuman primate.
Sorwell KG, Kohama SG, Urbanski HF. Sorwell KG, et al. Neurobiol Aging. 2012 Jul;33(7):1487.e1-13. doi: 10.1016/j.neurobiolaging.2011.05.004. Epub 2011 Jun 17. Neurobiol Aging. 2012. PMID: 21683476 Free PMC article.
Furthermore, real-time PCR reveals an age-related attenuation of hippocampal expression level of the genes CYP17A1, STS, and 3BHSD1/2. Additionally, short-term administration of estradiol is associated with decreased expression of CYP17A1, STS, SULT2B1, and AROMATASE, cons …
Furthermore, real-time PCR reveals an age-related attenuation of hippocampal expression level of the genes CYP17A1, STS, and 3BHSD1/2. Addit …
In vivo manipulation of gene expression in non-human primates using lentiviral vectors as delivery vehicles.
Dissen GA, Lomniczi A, Neff TL, Hobbs TR, Kohama SG, Kroenke CD, Galimi F, Ojeda SR. Dissen GA, et al. Methods. 2009 Sep;49(1):70-7. doi: 10.1016/j.ymeth.2009.06.004. Epub 2009 Jun 24. Methods. 2009. PMID: 19559089 Free PMC article. Review.
In addition, lentiviruses can permanently integrate into the genome of host cells, and are able to maintain long-term expression. In this article we describe the lentiviral vectors that we use to both express transgenes and suppress expression of endogenous genes via RNA i …
In addition, lentiviruses can permanently integrate into the genome of host cells, and are able to maintain long-term expression. In …
Influence of age and 17beta-estradiol on kisspeptin, neurokinin B, and prodynorphin gene expression in the arcuate-median eminence of female rhesus macaques.
Eghlidi DH, Haley GE, Noriega NC, Kohama SG, Urbanski HF. Eghlidi DH, et al. Endocrinology. 2010 Aug;151(8):3783-94. doi: 10.1210/en.2010-0198. Epub 2010 Jun 2. Endocrinology. 2010. PMID: 20519367 Free PMC article.
To test whether these age-related changes could be attributed to perimenopausal loss of sex steroids, we then examined KNDy, GPR54, NK3, and KOR expression changes in response to ovariectomy (OVX) and exposure to 17beta-estradiol (E(2)). Short-term (7 months) OVX (with or …
To test whether these age-related changes could be attributed to perimenopausal loss of sex steroids, we then examined KNDy, GPR54, NK3, and …
Fetal ventricular diastolic filling characteristics in a primate model: the role of fetal heart rate and pulmonary vascular impedance.
Hashima JN, Frias AE, Bernard L, Spindel ER, Hobbs TR, Rasanen J. Hashima JN, et al. Reprod Sci. 2010 Aug;17(8):760-6. doi: 10.1177/1933719110370490. Reprod Sci. 2010. PMID: 20595708 Free PMC article.
METHODS: Rhesus monkeys underwent Doppler ultrasonography at near-term gestation. Tricuspid (TV) and mitral valve (MV) blood velocity waveforms were used to calculate maximum velocity (V-max) and velocity time integral (VTI) E/A ratios (early filling/ventricular filling du …
METHODS: Rhesus monkeys underwent Doppler ultrasonography at near-term gestation. Tricuspid (TV) and mitral valve (MV) blood velocity …
Antiviral immunity following smallpox virus infection: a case-control study.
Hammarlund E, Lewis MW, Hanifin JM, Mori M, Koudelka CW, Slifka MK. Hammarlund E, et al. J Virol. 2010 Dec;84(24):12754-60. doi: 10.1128/JVI.01763-10. Epub 2010 Oct 6. J Virol. 2010. PMID: 20926574 Free PMC article.
These results indicate that severe, potentially life-threatening disease is not required for the development of sustainable long-term immunity. This study shows that the levels of immunity induced following smallpox vaccination are comparable in magnitude to that achieved …
These results indicate that severe, potentially life-threatening disease is not required for the development of sustainable long-term …
23 results