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Year Number of Results
2008 1
2009 1
2010 3
2012 2
2013 3
2014 2
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2019 2
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2023 1
2024 5

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27 results

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Page 1
The naked truth: a comprehensive clarification and classification of current 'myths' in naked mole-rat biology.
Buffenstein R, Amoroso V, Andziak B, Avdieiev S, Azpurua J, Barker AJ, Bennett NC, Brieño-Enríquez MA, Bronner GN, Coen C, Delaney MA, Dengler-Crish CM, Edrey YH, Faulkes CG, Frankel D, Friedlander G, Gibney PA, Gorbunova V, Hine C, Holmes MM, Jarvis JUM, Kawamura Y, Kutsukake N, Kenyon C, Khaled WT, Kikusui T, Kissil J, Lagestee S, Larson J, Lauer A, Lavrenchenko LA, Lee A, Levitt JB, Lewin GR, Lewis Hardell KN, Lin TD, Mason MJ, McCloskey D, McMahon M, Miura K, Mogi K, Narayan V, O'Connor TP, Okanoya K, O'Riain MJ, Park TJ, Place NJ, Podshivalova K, Pamenter ME, Pyott SJ, Reznick J, Ruby JG, Salmon AB, Santos-Sacchi J, Sarko DK, Seluanov A, Shepard A, Smith M, Storey KB, Tian X, Vice EN, Viltard M, Watarai A, Wywial E, Yamakawa M, Zemlemerova ED, Zions M, Smith ESJ. Buffenstein R, et al. Biol Rev Camb Philos Soc. 2022 Feb;97(1):115-140. doi: 10.1111/brv.12791. Epub 2021 Sep 3. Biol Rev Camb Philos Soc. 2022. PMID: 34476892 Free PMC article. Review.
., we argue that these 'myths' fall into four main categories: (i) 'myths' that would be better described as oversimplifications, some of which persist solely in the popular press; (ii) 'myths' that are based on incomplete understanding, where more evidence is clearly needed; (ii …
., we argue that these 'myths' fall into four main categories: (i) 'myths' that would be better described as oversimplifications, some of wh …
Drugs Targeting Mechanisms of Aging to Delay Age-Related Disease and Promote Healthspan: Proceedings of a National Institute on Aging Workshop.
Espinoza SE, Khosla S, Baur JA, de Cabo R, Musi N. Espinoza SE, et al. J Gerontol A Biol Sci Med Sci. 2023 Jun 16;78(Suppl 1):53-60. doi: 10.1093/gerona/glad034. J Gerontol A Biol Sci Med Sci. 2023. PMID: 37325957
However, much further research is needed to demonstrate benefits and general safety for wider use, the appropriate target populations, and longer-term outcomes....
However, much further research is needed to demonstrate benefits and general safety for wider use, the appropriate target populations, and l …
Effect of acute TLR4 inhibition on insulin resistance in humans.
Liang H, Sathavarodom N, Colmenares C, Gelfond J, Espinoza SE, Ganapathy V, Musi N. Liang H, et al. J Clin Invest. 2022 Nov 1;132(21):e162291. doi: 10.1172/JCI162291. J Clin Invest. 2022. PMID: 36066991 Free PMC article.
Eritoran also failed to improve any baseline metabolic parameters (M, FPG, FPI, HOMA-IR) in individuals with obesity and insulin resistance (protocol II).ConclusionsAcute TLR4 inhibition with eritoran did not protect against lipid-induced insulin resistance. Short-term eri …
Eritoran also failed to improve any baseline metabolic parameters (M, FPG, FPI, HOMA-IR) in individuals with obesity and insulin resistance …
Hepatic Insulin Resistance and Altered Gluconeogenic Pathway in Premature Baboons.
McGill-Vargas L, Gastaldelli A, Liang H, Anzueto Guerra D, Johnson-Pais T, Seidner S, McCurnin D, Muscogiuri G, DeFronzo R, Musi N, Blanco C. McGill-Vargas L, et al. Endocrinology. 2017 May 1;158(5):1140-1151. doi: 10.1210/en.2016-1806. Endocrinology. 2017. PMID: 28324053 Free PMC article.
The purpose of this study was to investigate developmental differences in glucose metabolism, hepatic protein content, and gene expression of key insulin-signaling/gluconeogenic molecules. Fetal baboons were delivered at 67%, 75%, and term gestational age and euthanized at …
The purpose of this study was to investigate developmental differences in glucose metabolism, hepatic protein content, and gene expression o …
Adaptations to chronic rapamycin in mice.
Dodds SG, Livi CB, Parihar M, Hsu HK, Benavides AD, Morris J, Javors M, Strong R, Christy B, Hasty P, Sharp ZD. Dodds SG, et al. Pathobiol Aging Age Relat Dis. 2016 May 27;6:31688. doi: 10.3402/pba.v6.31688. eCollection 2016. Pathobiol Aging Age Relat Dis. 2016. PMID: 27237224 Free PMC article.
Chronic treatment with encapsulated rapamycin (eRapa) extended health and life span for wild-type and cancer-prone mice. Yet, the long-term consequences of chronic eRapa treatment are not known at the organ level. ...
Chronic treatment with encapsulated rapamycin (eRapa) extended health and life span for wild-type and cancer-prone mice. Yet, the long-te …
Senescence in natural populations of animals: widespread evidence and its implications for bio-gerontology.
Nussey DH, Froy H, Lemaitre JF, Gaillard JM, Austad SN. Nussey DH, et al. Ageing Res Rev. 2013 Jan;12(1):214-25. doi: 10.1016/j.arr.2012.07.004. Epub 2012 Aug 4. Ageing Res Rev. 2013. PMID: 22884974 Free PMC article. Review.
We identify the roots of this fallacy in the otherwise seminal works of Medawar and Comfort, and explain that under antagonistic pleiotropy or disposable soma explanations for the evolution of senescence there is no reason why senescence cannot evolve to be manifest within the li …
We identify the roots of this fallacy in the otherwise seminal works of Medawar and Comfort, and explain that under antagonistic pleiotropy …
Hypothalamic sex-specific metabolic shift by canagliflozin during aging.
Jayarathne HSM, Sullivan R, Stilgenbauer L, Debarba LK, Kuchumov A, Koshko L, Scofield S, Liu W, Ginsburg BC, Miller RA, Sadagurski M. Jayarathne HSM, et al. Geroscience. 2024 May 27. doi: 10.1007/s11357-024-01214-z. Online ahead of print. Geroscience. 2024. PMID: 38801647
Recent studies have shown that a SGLT2i, Canagliflozin (Cana), can extend the median survival of genetically heterogeneous UM-HET3 male mice and improve central metabolic control via increases in hypothalamic insulin responsiveness in aged males, as well as reduced age-associated …
Recent studies have shown that a SGLT2i, Canagliflozin (Cana), can extend the median survival of genetically heterogeneous UM-HET3 male mice …
Evaluation of the pharmacokinetics of metformin and acarbose in the common marmoset.
Fernandez E, Ross C, Liang H, Javors M, Tardif S, Salmon AB. Fernandez E, et al. Pathobiol Aging Age Relat Dis. 2019 Aug 22;9(1):1657756. doi: 10.1080/20010001.2019.1657756. eCollection 2019. Pathobiol Aging Age Relat Dis. 2019. PMID: 31497263 Free PMC article.
The ability to rapidly and reliably dose socially housed marmosets with an oral form of acarbose or metformin that is well tolerated indicates that this species is a reliable model for testing acarbose and metformin in a safe and efficient way in a long-term intervention.. …
The ability to rapidly and reliably dose socially housed marmosets with an oral form of acarbose or metformin that is well tolerated indicat …
Chronic mTOR inhibition in mice with rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune-deficient mice.
Hurez V, Dao V, Liu A, Pandeswara S, Gelfond J, Sun L, Bergman M, Orihuela CJ, Galvan V, Padrón Á, Drerup J, Liu Y, Hasty P, Sharp ZD, Curiel TJ. Hurez V, et al. Aging Cell. 2015 Dec;14(6):945-56. doi: 10.1111/acel.12380. Epub 2015 Aug 28. Aging Cell. 2015. PMID: 26315673 Free PMC article.
Rapamycin or related analogues (rapalogues) also mitigate age-related debilities including increasing antigen-specific immunity, improving vaccine responses in elderly humans, and treating cancers and autoimmunity, suggesting important new clinical applications. Nonetheless, immu …
Rapamycin or related analogues (rapalogues) also mitigate age-related debilities including increasing antigen-specific immunity, improving v …
27 results