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Page 1
Human liver model systems in a dish.
Thompson WL, Takebe T. Thompson WL, et al. Dev Growth Differ. 2021 Jan;63(1):47-58. doi: 10.1111/dgd.12708. Epub 2021 Feb 2. Dev Growth Differ. 2021. PMID: 33423319 Free PMC article. Review.
Due to the liver's intricate structure, there are many challenges to design differentiation protocols to generate more mature functional hepatocytes from human stem cells and maintain the long-term viability and functionality of primary hepatocytes. To this end, recent adv …
Due to the liver's intricate structure, there are many challenges to design differentiation protocols to generate more mature functional hep …
Modelling human hepato-biliary-pancreatic organogenesis from the foregut-midgut boundary.
Koike H, Iwasawa K, Ouchi R, Maezawa M, Giesbrecht K, Saiki N, Ferguson A, Kimura M, Thompson WL, Wells JM, Zorn AM, Takebe T. Koike H, et al. Nature. 2019 Oct;574(7776):112-116. doi: 10.1038/s41586-019-1598-0. Epub 2019 Sep 25. Nature. 2019. PMID: 31554966 Free PMC article.
Whereas transplant-derived tissues are dominated by midgut derivatives, long-term-cultured microdissected hepato-biliary-pancreatic organoids develop into segregated multi-organ anlages, which then recapitulate early morphogenetic events including the invagination and bran …
Whereas transplant-derived tissues are dominated by midgut derivatives, long-term-cultured microdissected hepato-biliary-pancreatic o …
Clinical Applications of the Eosinophilic Esophagitis Diagnostic Panel.
Wen T, Rothenberg ME. Wen T, et al. Front Med (Lausanne). 2017 Jul 14;4:108. doi: 10.3389/fmed.2017.00108. eCollection 2017. Front Med (Lausanne). 2017. PMID: 28770203 Free PMC article. Review.
In addition to providing a definitive EoE diagnosis with high accuracy, the EDP has been useful in elucidating several key elements about the disease including the efficacy of specific drugs such as swallowed glucocorticoids and anti-IL-13 humanized antibody therapy, the relation …
In addition to providing a definitive EoE diagnosis with high accuracy, the EDP has been useful in elucidating several key elements about th …
Eosinophil Involvement Outside the Esophagus in Eosinophilic Esophagitis.
Sato H, Taylor RJ, Sakai N, Osonoi K, Rothenberg ME, Shoda T. Sato H, et al. Clin Gastroenterol Hepatol. 2024 Jul;22(7):1531-1534.e2. doi: 10.1016/j.cgh.2023.12.004. Epub 2023 Dec 15. Clin Gastroenterol Hepatol. 2024. PMID: 38103874 Review.
Notably, in a survey of these experts, 61% agreed with the later term "non-EoE EGID with EI," because EoE is isolated to the esophagus by current diagnostic criteria.(3) However, limited molecular and pathogenic data exist to support the distinction. ...
Notably, in a survey of these experts, 61% agreed with the later term "non-EoE EGID with EI," because EoE is isolated to the esophagu …
Colivelin, a synthetic derivative of humanin, ameliorates endothelial injury and glycocalyx shedding after sepsis in mice.
Urban C, Hayes HV, Piraino G, Wolfe V, Lahni P, O'Connor M, Phares C, Zingarelli B. Urban C, et al. Front Immunol. 2022 Sep 2;13:984298. doi: 10.3389/fimmu.2022.984298. eCollection 2022. Front Immunol. 2022. PMID: 36119052 Free PMC article.
At molecular analysis, colivelin treatment was associated with inhibition of the signal transducer and activator of transcription 3 and activation of the AMP-activated protein kinase in the aorta and lung. In long-term outcomes studies up to 7 days, co-treatment of colivel …
At molecular analysis, colivelin treatment was associated with inhibition of the signal transducer and activator of transcription 3 and acti …
Pathogenesis of biliary atresia: defining biology to understand clinical phenotypes.
Asai A, Miethke A, Bezerra JA. Asai A, et al. Nat Rev Gastroenterol Hepatol. 2015 Jun;12(6):342-52. doi: 10.1038/nrgastro.2015.74. Epub 2015 May 26. Nat Rev Gastroenterol Hepatol. 2015. PMID: 26008129 Free PMC article. Review.
Although this approach can improve the short-term outcome, the liver disease progresses to end-stage cirrhosis in most children. Further improvement in outcome will require a greater understanding of the mechanisms of biliary injury and fibrosis. ...
Although this approach can improve the short-term outcome, the liver disease progresses to end-stage cirrhosis in most children. Furt …
Lipopolysaccharide suppresses IgE-mast cell-mediated reactions.
Wang N, McKell M, Dang A, Yamani A, Waggoner L, Vanoni S, Noah T, Wu D, Kordowski A, Köhl J, Hoebe K, Divanovic S, Hogan SP. Wang N, et al. Clin Exp Allergy. 2017 Dec;47(12):1574-1585. doi: 10.1111/cea.13013. Epub 2017 Oct 10. Clin Exp Allergy. 2017. PMID: 28833704 Free PMC article.
Notably, LPS-induced desensitization of MCs was short term with MC sensitivity to IgE reconstituted within 48 hours, which was associated with recapitulation of FcepsilonRI expression on the MCs. ...
Notably, LPS-induced desensitization of MCs was short term with MC sensitivity to IgE reconstituted within 48 hours, which was associ …
Nutritional Risks in Adolescents After Bariatric Surgery.
Xanthakos SA, Khoury JC, Inge TH, Jenkins TM, Modi AC, Michalsky MP, Chen MK, Courcoulas AP, Harmon CM, Brandt ML, Helmrath MA, Kalkwarf HJ; Teen Longitudinal Assessment of Bariatric Surgery Consortium. Xanthakos SA, et al. Clin Gastroenterol Hepatol. 2020 May;18(5):1070-1081.e5. doi: 10.1016/j.cgh.2019.10.048. Epub 2019 Nov 6. Clin Gastroenterol Hepatol. 2020. PMID: 31706057 Free PMC article.
PROTECTIVE EFFECTS OF HUMANIN-G IN HEMORRHAGIC SHOCK IN FEMALE MICE VIA AMPKα1-INDEPENDENT MECHANISMS.
Wagner ML, Ammann A, Piraino G, Wolfe V, O'Connor M, Lahni P, Ziady A, Zingarelli B. Wagner ML, et al. Shock. 2023 Jul 1;60(1):64-74. doi: 10.1097/SHK.0000000000002134. Epub 2023 Apr 21. Shock. 2023. PMID: 37079467 Free PMC article.
Methods: AMPKalpha1 wild-type (WT) and knockout (KO) female mice were subjected to hemorrhagic shock followed by resuscitation with blood and lactated Ringer's solution. In short-term studies, mice were treated with humanin-G or vehicle and sacrificed at 3 h after resuscit …
Methods: AMPKalpha1 wild-type (WT) and knockout (KO) female mice were subjected to hemorrhagic shock followed by resuscitation with blood an …
Engineering human hepato-biliary-pancreatic organoids from pluripotent stem cells.
Koike H, Iwasawa K, Ouchi R, Maezawa M, Kimura M, Kodaka A, Nishii S, Thompson WL, Takebe T. Koike H, et al. Nat Protoc. 2021 Feb;16(2):919-936. doi: 10.1038/s41596-020-00441-w. Epub 2021 Jan 11. Nat Protoc. 2021. PMID: 33432231 Free PMC article.
Subsequently, self-patterning of multi-organ (i.e., HBP) domains occurs within the boundary region of the two spheroids, even in the absence of any extrinsic factors. Long-term culture of HBP structures induces differentiation of the domains into segregated organs complete …
Subsequently, self-patterning of multi-organ (i.e., HBP) domains occurs within the boundary region of the two spheroids, even in the absence …
54 results