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The roles of latency-associated antigens in tuberculosis vaccines.
Yousefi Avarvand A, Khademi F, Tafaghodi M, Ahmadipour Z, Moradi B, Meshkat Z. Yousefi Avarvand A, et al. Indian J Tuberc. 2019 Oct;66(4):487-491. doi: 10.1016/j.ijtb.2019.04.012. Epub 2019 May 1. Indian J Tuberc. 2019. PMID: 31813436 Review.
Tuberculosis (TB) is a re-emerging disease and is caused by Mycobacterium tuberculosis (M. tuberculosis). TB is currently one of the leading causes of morbidity and mortality, worldwide. ...To produce a multi-stage subunit vaccine, scientists should combine the early secre …
Tuberculosis (TB) is a re-emerging disease and is caused by Mycobacterium tuberculosis (M. tuberculosis). TB is currently one of the …
Dry Powder form of Polymeric Nanoparticles for Pulmonary Drug Delivery.
Shiehzadeh F, Tafaghodi M. Shiehzadeh F, et al. Curr Pharm Des. 2016;22(17):2549-60. doi: 10.2174/1381612822666160128150449. Curr Pharm Des. 2016. PMID: 26818872 Review.
The prolonged residence of NPs in the lungs due to ability to escape from the clearance mechanisms such as mucociliary escalator, macrophage uptake (a size of 1-2 m is ideal for macrophage phagocytosis), and translocation to the systemic circulation is amongst the key adva …
The prolonged residence of NPs in the lungs due to ability to escape from the clearance mechanisms such as mucociliary escalator, macrophage …
Potential of polymeric particles as future vaccine delivery systems/adjuvants for parenteral and non-parenteral immunization against tuberculosis: A systematic review.
Khademi F, Derakhshan M, Yousefi-Avarvand A, Tafaghodi M. Khademi F, et al. Iran J Basic Med Sci. 2018 Feb;21(2):116-123. doi: 10.22038/IJBMS.2017.22059.5648. Iran J Basic Med Sci. 2018. PMID: 29456807 Free PMC article. Review.
The present study revealed that various polymeric particles, after M. tuberculosis challenge in animal models, provide long-lasting protection against TB. ...
The present study revealed that various polymeric particles, after M. tuberculosis challenge in animal models, provide long-lasting p …
A novel formulation of Mtb72F DNA vaccine for immunization against tuberculosis.
Dalirfardouei R, Tafaghodi M, Meshkat Z, Najafi A, Gholoobi A, Nabavinia MS, Sajedifar S, Meshkat M, Badiee A, Ramezani M, Varasteh AR, Naderinasab M. Dalirfardouei R, et al. Iran J Basic Med Sci. 2020 Jun;23(6):826-832. doi: 10.22038/ijbms.2020.41806.9881. Iran J Basic Med Sci. 2020. PMID: 32695300 Free PMC article.
OBJECTIVES: Mycobacterium tuberculosis (M. tuberculosis), an intracellular pathogen, causes 1.5 million deaths globally. Bacilli Calmette-Guerin (BCG) is commonly administered to protect people against M. tuberculosis infection; however, there are some obstacles wit …
OBJECTIVES: Mycobacterium tuberculosis (M. tuberculosis), an intracellular pathogen, causes 1.5 million deaths globally. Bacilli Calm …
Immunogenicity of HspX/EsxS fusion protein of Mycobacterium tuberculosis along with ISCOMATRIX and PLUSCOM nano-adjuvants after subcutaneous administration in animal model.
Yousefi Avarvand A, Meshkat Z, Khademi F, Tafaghodi M. Yousefi Avarvand A, et al. Microb Pathog. 2021 May;154:104842. doi: 10.1016/j.micpath.2021.104842. Epub 2021 Mar 21. Microb Pathog. 2021. PMID: 33762199
BACKGROUND: Tuberculosis (TB), caused by Mycobacterium tuberculosis (M. tuberculosis), is one of the most common and dangerous infectious diseases in the world. ...METHODS: HspX/EsxS fused protein of M. tuberculosis was cloned, expressed and purified in the prokaryo …
BACKGROUND: Tuberculosis (TB), caused by Mycobacterium tuberculosis (M. tuberculosis), is one of the most common and dangerous infect …
Enhancing immunogenicity of novel multistage subunit vaccine of Mycobacterium tuberculosis using PLGA:DDA hybrid nanoparticles and MPLA: Subcutaneous administration.
Khademi F, Yousefi A, Derakhshan M, Najafi A, Tafaghodi M. Khademi F, et al. Iran J Basic Med Sci. 2019 Aug;22(8):893-900. doi: 10.22038/ijbms.2019.33962.8079. Iran J Basic Med Sci. 2019. PMID: 31579445 Free PMC article.
The aim of the present study was to evaluate the PLGA:DDA hybrid nanoparticles (NPs) for subcutaneous delivery of a novel multistage subunit vaccine along with MPLA adjuvant against Mycobacterium tuberculosis (M. tuberculosis). MATERIALS AND METHODS: PLGA and PLGA:DDA NPs …
The aim of the present study was to evaluate the PLGA:DDA hybrid nanoparticles (NPs) for subcutaneous delivery of a novel multistage subunit …
Enhancement of the immunogenicity of a Mycobacterium tuberculosis fusion protein using ISCOMATRIX and PLUSCOM nano-adjuvants as prophylactic vaccine after nasal administration in mice.
Yousefi Avarvand A, Meshkat Z, Khademi F, Aryan E, Sankian M, Tafaghodi M. Yousefi Avarvand A, et al. Iran J Basic Med Sci. 2024;27(1):24-30. doi: 10.22038/IJBMS.2023.69295.15100. Iran J Basic Med Sci. 2024. PMID: 38164481 Free PMC article.
OBJECTIVES: Tuberculosis (TB), a contagious disease caused by Mycobacterium tuberculosis (M. tuberculosis), remains a health problem worldwide and this infection has the highest mortality rate among bacterial infections. Current studies suggest that intranasal administrati …
OBJECTIVES: Tuberculosis (TB), a contagious disease caused by Mycobacterium tuberculosis (M. tuberculosis), remains a health problem …
Preparation and Characterization of a Dry Powder Inhaler Composed of PLGA Large Porous Particles Encapsulating Gentamicin Sulfate.
Shiehzadeh F, Tafaghodi M, Dehghani ML, Mashhoori F, Fazly Bazzaz BS, Imenshahidi M. Shiehzadeh F, et al. Adv Pharm Bull. 2019 Jun;9(2):255-261. doi: 10.15171/apb.2019.029. Epub 2019 Jun 1. Adv Pharm Bull. 2019. PMID: 31380251 Free PMC article.
Mass median aerodynamic diameter (MMAD) and fine particle fraction (FPF) were 4.9 m and 39% respectively. Conclusion: In this study, dry powder formulation composed of PLGA LPPs encapsulating gentamicin sulfate showed a promising in vitro behavior as a pulmonary delivery c …
Mass median aerodynamic diameter (MMAD) and fine particle fraction (FPF) were 4.9 m and 39% respectively. Conclusion: In this study, …
Impact of chitosan coating of anionic liposomes on clearance rate, mucosal and systemic immune responses following nasal administration in rabbits.
Amin M, Jaafari MR, Tafaghodi M. Amin M, et al. Colloids Surf B Biointerfaces. 2009 Nov 1;74(1):225-9. doi: 10.1016/j.colsurfb.2009.07.024. Epub 2009 Jul 25. Colloids Surf B Biointerfaces. 2009. PMID: 19699067 Clinical Trial.
The serum IgG titers (2nd bleeding) in animals immunized by both kinds of liposome were similar (P>0.05), and were lower than the TT solution group (P<0.05). Immunization by i.m. injection of TT solution resulted in the lowest sIgA and highest IgG titers (P<0.05) …
The serum IgG titers (2nd bleeding) in animals immunized by both kinds of liposome were similar (P>0.05), and were lower than the TT solu …
15 results