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Differences Between Plasma and Cerebrospinal Fluid Glial Fibrillary Acidic Protein Levels Across the Alzheimer Disease Continuum.
Benedet AL, Milà-Alomà M, Vrillon A, Ashton NJ, Pascoal TA, Lussier F, Karikari TK, Hourregue C, Cognat E, Dumurgier J, Stevenson J, Rahmouni N, Pallen V, Poltronetti NM, Salvadó G, Shekari M, Operto G, Gispert JD, Minguillon C, Fauria K, Kollmorgen G, Suridjan I, Zimmer ER, Zetterberg H, Molinuevo JL, Paquet C, Rosa-Neto P, Blennow K, Suárez-Calvet M; Translational Biomarkers in Aging and Dementia (TRIAD) study, Alzheimer’s and Families (ALFA) study, and BioCogBank Paris Lariboisière cohort. Benedet AL, et al. JAMA Neurol. 2021 Dec 1;78(12):1471-1483. doi: 10.1001/jamaneurol.2021.3671. JAMA Neurol. 2021. PMID: 34661615 Free PMC article.
Genetic, vascular and amyloid components of cerebral blood flow in a preclinical population.
Padrela BE, Lorenzini L, Collij LE, García DV, Coomans E, Ingala S, Tomassen J, Deckers Q, Shekari M, Geus EJ, van de Giessen E, Kate MT, Visser PJ, Barkhof F, Petr J, Braber AD, Mutsaerts HJ. Padrela BE, et al. J Cereb Blood Flow Metab. 2023 Oct;43(10):1726-1736. doi: 10.1177/0271678X231178993. Epub 2023 May 26. J Cereb Blood Flow Metab. 2023. PMID: 37231665 Free PMC article.
We included 134 participants who underwent arterial spin labeling (ASL) MRI and [(18)F]flutemetamol amyloid-PET imaging at baseline and after a four-year follow-up. ...
We included 134 participants who underwent arterial spin labeling (ASL) MRI and [(18)F]flutemetamol amyloid-PET imaging at baseline a …
Quantification of [(18) F]florbetaben amyloid-PET imaging in a mixed memory clinic population: The ABIDE project.
Collij LE, Salvadó G, de Wilde A, Altomare D, Shekari M, Gispert JD, Bullich S, Stephens A, Barkhof F, Scheltens P, Bouwman F, van der Flier WM. Collij LE, et al. Alzheimers Dement. 2023 Jun;19(6):2397-2407. doi: 10.1002/alz.12886. Epub 2022 Dec 7. Alzheimers Dement. 2023. PMID: 36478646
INTRODUCTION: We investigated amyloid-burden quantification in a mixed memory clinic population. METHODS: [(18) F]Florbetaben amyloid-PET (positron emission tomography) scans of 348 patients were visually read and quantified using the Centiloid (CL) method. ...Linear mixed …
INTRODUCTION: We investigated amyloid-burden quantification in a mixed memory clinic population. METHODS: [(18) F]Florbetaben amyloid …
Visual assessment of [(18)F]flutemetamol PET images can detect early amyloid pathology and grade its extent.
Collij LE, Salvadó G, Shekari M, Lopes Alves I, Reimand J, Wink AM, Zwan M, Niñerola-Baizán A, Perissinotti A, Scheltens P, Ikonomovic MD, Smith APL, Farrar G, Molinuevo JL, Barkhof F, Buckley CJ, van Berckel BNM, Gispert JD; ALFA study; AMYPAD consortium. Collij LE, et al. Eur J Nucl Med Mol Imaging. 2021 Jul;48(7):2169-2182. doi: 10.1007/s00259-020-05174-2. Epub 2021 Feb 22. Eur J Nucl Med Mol Imaging. 2021. PMID: 33615397 Free PMC article.
PURPOSE: To investigate the sensitivity of visual read (VR) to detect early amyloid pathology and the overall utility of regional VR. METHODS: [(18)F]Flutemetamol PET images of 497 subjects (ALFA+ N = 352; ADC N = 145) were included. ...Global and regional CL quantificatio …
PURPOSE: To investigate the sensitivity of visual read (VR) to detect early amyloid pathology and the overall utility of regional VR. METHOD …
The amyloid imaging for the prevention of Alzheimer's disease consortium: A European collaboration with global impact.
Collij LE, Farrar G, Valléz García D, Bader I, Shekari M, Lorenzini L, Pemberton H, Altomare D, Pla S, Loor M, Markiewicz P, Yaqub M, Buckley C, Frisoni GB, Nordberg A, Payoux P, Stephens A, Gismondi R, Visser PJ, Ford L, Schmidt M, Birck C, Georges J, Mett A, Walker Z, Boada M, Drzezga A, Vandenberghe R, Hanseeuw B, Jessen F, Schöll M, Ritchie C, Lopes Alves I, Gispert JD, Barkhof F. Collij LE, et al. Front Neurol. 2023 Jan 20;13:1063598. doi: 10.3389/fneur.2022.1063598. eCollection 2022. Front Neurol. 2023. PMID: 36761917 Free PMC article. Review.
Approximately 1600 unique subjects with historical and prospective data were collected within this study. PET acquisition with [(18)F]flutemetamol or [(18)F]florbetaben radiotracers was performed and quantified using the Centiloid (CL) method. ...
Approximately 1600 unique subjects with historical and prospective data were collected within this study. PET acquisition with [(18)F …
Astrocyte biomarkers GFAP and YKL-40 mediate early Alzheimer's disease progression.
Pelkmans W, Shekari M, Brugulat-Serrat A, Sánchez-Benavides G, Minguillón C, Fauria K, Molinuevo JL, Grau-Rivera O, González Escalante A, Kollmorgen G, Carboni M, Ashton NJ, Zetterberg H, Blennow K, Suarez-Calvet M, Gispert JD; ALFA study. Pelkmans W, et al. Alzheimers Dement. 2024 Jan;20(1):483-493. doi: 10.1002/alz.13450. Epub 2023 Sep 10. Alzheimers Dement. 2024. PMID: 37690071 Free PMC article.
A multisite analysis of the concordance between visual image interpretation and quantitative analysis of [(18)F]flutemetamol amyloid PET images.
Bucci M, Savitcheva I, Farrar G, Salvadó G, Collij L, Doré V, Gispert JD, Gunn R, Hanseeuw B, Hansson O, Shekari M, Lhommel R, Molinuevo JL, Rowe C, Sur C, Whittington A, Buckley C, Nordberg A. Bucci M, et al. Eur J Nucl Med Mol Imaging. 2021 Jul;48(7):2183-2199. doi: 10.1007/s00259-021-05311-5. Epub 2021 Apr 12. Eur J Nucl Med Mol Imaging. 2021. PMID: 33844055 Free PMC article.
BACKGROUND: [(18)F]flutemetamol PET scanning provides information on brain amyloid load and has been approved for routine clinical use based upon visual interpretation as either negative (equating to none or sparse amyloid plaques) or amyloid positive (equating to moderate …
BACKGROUND: [(18)F]flutemetamol PET scanning provides information on brain amyloid load and has been approved for routine clinical us …
Investigating reliable amyloid accumulation in Centiloids: Results from the AMYPAD Prognostic and Natural History Study.
Bollack A, Collij LE, García DV, Shekari M, Altomare D, Payoux P, Dubois B, Grau-Rivera O, Boada M, Marquié M, Nordberg A, Walker Z, Scheltens P, Schöll M, Wolz R, Schott JM, Gismondi R, Stephens A, Buckley C, Frisoni GB, Hanseeuw B, Visser PJ, Vandenberghe R, Drzezga A, Yaqub M, Boellaard R, Gispert JD, Markiewicz P, Cash DM, Farrar G, Barkhof F; AMYPAD consortium. Bollack A, et al. Alzheimers Dement. 2024 May;20(5):3429-3441. doi: 10.1002/alz.13761. Epub 2024 Apr 4. Alzheimers Dement. 2024. PMID: 38574374 Free PMC article.
METHODS: A total of 1032 participants from the Amyloid Imaging to Prevent Alzheimer's Disease-Prognostic and Natural History Study (AMYPAD-PNHS) and Insight46 who underwent [(18)F]flutemetamol, [(18)F]florbetaben or [(18)F]florbetapir amyloid-PET were include …
METHODS: A total of 1032 participants from the Amyloid Imaging to Prevent Alzheimer's Disease-Prognostic and Natural History Study (AMYPAD-P …
20 results