Design, synthesis and evaluation of novel 2-phenyl-3-(1H-pyrazol-4-yl)pyridine positive allosteric modulators for the M4 mAChR.
Jörg M, van der Westhuizen ET, Lu Y, Christopher Choy KH, Shackleford DM, Khajehali E, Tobin AB, Thal DM, Capuano B, Christopoulos A, Valant C, Scammells PJ.
Jörg M, et al.
Eur J Med Chem. 2023 Oct 5;258:115588. doi: 10.1016/j.ejmech.2023.115588. Epub 2023 Jul 1.
Eur J Med Chem. 2023.
PMID: 37423123
Herein, we report the synthesis and comprehensive pharmacological evaluation of M(4) mAChR PAMs structurally related to 1e, Me-C-c, [(11)C]MK-6884 and [(18)F]12. Our results show that small structural changes to the PAMs can result in pronounced differences to baseline, po …
Herein, we report the synthesis and comprehensive pharmacological evaluation of M(4) mAChR PAMs structurally related to 1e, Me-C-c, [(11)C]M …