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Theophylline inhibits tolerance and sensitization induced by morphine: a conditioned place preference paradigm study in female mice.
Sahraei H, Barzegari AA, Shams J, Zarrindast MR, Haeri-Rohani A, Ghoshooni H, Sepehri H, Salimi SH. Sahraei H, et al. Behav Pharmacol. 2006 Nov;17(7):621-8. doi: 10.1097/01.fbp.0000236274.18042.54. Behav Pharmacol. 2006. PMID: 17021395
Administration of morphine (12.5, 25 or 50 mg/kg) daily, for 3 days, produced tolerance to conditioned place preference induced by the drug (5 mg/kg). Administration of theophylline (2.5 and 10 mg/kg) 1 h before morphine (12.5, 25 mg/kg), during development of tolerance, a …
Administration of morphine (12.5, 25 or 50 mg/kg) daily, for 3 days, produced tolerance to conditioned place preference induced by the drug …