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Page 1
Radiosensitizing effect of dendrosomal nanoformulation of curcumin on cancer cells.
Varnamkhasti TJ, Jafarzadeh M, Sadeghizadeh M, Aghili M. Varnamkhasti TJ, et al. Pharmacol Rep. 2022 Aug;74(4):718-735. doi: 10.1007/s43440-022-00383-y. Epub 2022 Jul 10. Pharmacol Rep. 2022. PMID: 35819593
Further experiments then indicated that DNC could effectively induce G2/M phase cell cycle arrest and apoptosis following irradiation. ...
Further experiments then indicated that DNC could effectively induce G2/M phase cell cycle arrest and apoptosis following irradiation …
Mitochondria-Targeted Polyamidoamine Dendrimer-Curcumin Construct for Hepatocellular Cancer Treatment.
Kianamiri S, Dinari A, Sadeghizadeh M, Rezaei M, Daraei B, Bahsoun NE, Nomani A. Kianamiri S, et al. Mol Pharm. 2020 Dec 7;17(12):4483-4498. doi: 10.1021/acs.molpharmaceut.0c00566. Epub 2020 Nov 18. Mol Pharm. 2020. PMID: 33205974
Our findings showed that the targeted-dendrimeric curcumin (TDC) could successfully deliver and colocalize the drug to the mitochondria of the cancer cells, and selectively induce a potent apoptosis and cell cycle arrest at G2/M. Moreover, at a low curcumin dose of less th …
Our findings showed that the targeted-dendrimeric curcumin (TDC) could successfully deliver and colocalize the drug to the mitochondria of t …
Up-regulation of miR-21 decreases chemotherapeutic effect of dendrosomal curcumin in breast cancer cells.
Esmatabadi MJD, Farhangi B, Montazeri M, Monfared H, Sistani RN, Sadeghizadeh M. Esmatabadi MJD, et al. Iran J Basic Med Sci. 2017 Apr;20(4):350-359. doi: 10.22038/IJBMS.2017.8574. Iran J Basic Med Sci. 2017. PMID: 28804605 Free PMC article.
Furthermore, DNC induced a marked increase in the number of cells in sub G1/G1 phase and a decrease in G2/M phase of the cell cycle in both; but, we observed reverse results compared it, after transfection with miR-21 vector. ...
Furthermore, DNC induced a marked increase in the number of cells in sub G1/G1 phase and a decrease in G2/M phase of the cell cycle i …
Down-regulation of lncRNA, GAS5 decreases chemotherapeutic effect of dendrosomal curcumin (DNC) in breast cancer cells.
Esmatabadi MJD, Motamedrad M, Sadeghizadeh M. Esmatabadi MJD, et al. Phytomedicine. 2018 Mar 15;42:56-65. doi: 10.1016/j.phymed.2018.03.022. Epub 2018 Mar 13. Phytomedicine. 2018. PMID: 29655698
Furthermore, DNC induced a significant increase in the number of cells in sub G1/G1 phase and a decrease in the G2/M phase of the cell cycle. But, after GAS5 down-regulation alone opposite results was observed compared to DNC. ...
Furthermore, DNC induced a significant increase in the number of cells in sub G1/G1 phase and a decrease in the G2/M phase of the cel …
Antiproliferative and Apoptotic Effect of Dendrosomal Curcumin Nanoformulation in P53 Mutant and Wide-Type Cancer Cell Lines.
Montazeri M, Pilehvar-Soltanahmadi Y, Mohaghegh M, Panahi A, Khodi S, Zarghami N, Sadeghizadeh M. Montazeri M, et al. Anticancer Agents Med Chem. 2017;17(5):662-673. doi: 10.2174/1871520616666160815124537. Anticancer Agents Med Chem. 2017. PMID: 27604683
RESULTS: During the time, DNC increased the SubG1 cells and decreased G1, S and G2/M cells, early apoptosis also indicated the inhibition of cell growth in early phase. ...
RESULTS: During the time, DNC increased the SubG1 cells and decreased G1, S and G2/M cells, early apoptosis also indicated the inhibi …
Nanoformulation of curcumin protects HUVEC endothelial cells against ionizing radiation and suppresses their adhesion to monocytes: potential in prevention of radiation-induced atherosclerosis.
Soltani B, Bodaghabadi N, Mahpour G, Ghaemi N, Sadeghizadeh M. Soltani B, et al. Biotechnol Lett. 2016 Dec;38(12):2081-2088. doi: 10.1007/s10529-016-2189-x. Epub 2016 Aug 24. Biotechnol Lett. 2016. PMID: 27558390
RESULTS: Co(60) gamma rays reduced viability, raised the expression of adhesion molecules, ICAM-1, VCAM-1 and E-selectin (mRNA and protein), augmented the adhesion of THP-1 cells to HUVECs, activated NF-kappaB binding, increased the release of pro-inflammatory cytokines (IL-6, IL …
RESULTS: Co(60) gamma rays reduced viability, raised the expression of adhesion molecules, ICAM-1, VCAM-1 and E-selectin (mRNA and protein), …
19 results