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786 results

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Page 1
A Structural Perspective of the Role of IP6 in Immature and Mature Retroviral Assembly.
Obr M, Schur FKM, Dick RA. Obr M, et al. Viruses. 2021 Sep 17;13(9):1853. doi: 10.3390/v13091853. Viruses. 2021. PMID: 34578434 Free PMC article. Review.
However, the molecular details underlying this effect have been determined only recently, with the identification of the IP6 binding site in the immature Gag lattice. IP6 also promotes formation of the mature capsid protein (CA) lattice via a second IP6 bindi …
However, the molecular details underlying this effect have been determined only recently, with the identification of the IP6 binding …
Monitoring Intracellular IP6 with a Genetically Encoded Fluorescence Biosensor.
Li X, Wei Q, Zhao K, Wang W, Liu B, Li W, Wang J. Li X, et al. ACS Sens. 2023 Dec 22;8(12):4484-4493. doi: 10.1021/acssensors.3c00268. Epub 2023 Nov 21. ACS Sens. 2023. PMID: 38079595
We also provide proof-of-concept evidence that HIPSer can monitor IP6 levels in real time in HEK293T cells and can be targeted for IP6 detection in the nucleus of HEK293T cells. Moreover, HIPSer could also detect changes in IP6 content induced by chemical inh …
We also provide proof-of-concept evidence that HIPSer can monitor IP6 levels in real time in HEK293T cells and can be targeted for …
IP6: a novel anti-cancer agent.
Shamsuddin AM, Vucenik I, Cole KE. Shamsuddin AM, et al. Life Sci. 1997;61(4):343-54. doi: 10.1016/s0024-3205(97)00092-1. Life Sci. 1997. PMID: 9244360 Review.
A striking anti-cancer action of IP6 has been demonstrated both in vivo and in vitro, which is based on the hypotheses that exogenously administered IP6 may be internalized, dephosphorylated to IP(1-5), and inhibit cell growth. There is additional evidence that Ins …
A striking anti-cancer action of IP6 has been demonstrated both in vivo and in vitro, which is based on the hypotheses that exogenous …
Role of Inositols and Inositol Phosphates in Energy Metabolism.
Chatree S, Thongmaen N, Tantivejkul K, Sitticharoon C, Vucenik I. Chatree S, et al. Molecules. 2020 Nov 1;25(21):5079. doi: 10.3390/molecules25215079. Molecules. 2020. PMID: 33139672 Free PMC article. Review.
Recently, inositols, especially myo-inositol and inositol hexakisphosphate, also known as phytic acid or IP6, with their biological activities received much attention for their role in multiple health beneficial effects. ...
Recently, inositols, especially myo-inositol and inositol hexakisphosphate, also known as phytic acid or IP6, with their biological a …
A novel 6-pyrophosphorylating IP6 kinase (IP6-6K) discovered in the protozoon Trichomonas vaginalis.
Wundenberg T, Nalaskowski MM, Löser B, Fanick W, Hackl T, Fürnkranz U, Rehbach C, Lin H, Mayr GW. Wundenberg T, et al. Mol Biochem Parasitol. 2019 Jan;227:53-63. doi: 10.1016/j.molbiopara.2018.12.004. Epub 2018 Dec 26. Mol Biochem Parasitol. 2019. PMID: 30593849
When characterizing the purified protein product of tvip6k1, we discovered that the major activity of the highly active enzyme (2 mumol/min/mg) is a conversion of InsP(6) to 6PP-InsP(5) and not 5PP-InsP(5) as by animal isoforms. Thus TvIP6K1 is a novel IP6-6K. The enzyme a …
When characterizing the purified protein product of tvip6k1, we discovered that the major activity of the highly active enzyme (2 mumol/min/ …
Metabolism and cellular functions of IP6: a review.
Shamsuddin AM. Shamsuddin AM. Anticancer Res. 1999 Sep-Oct;19(5A):3733-6. Anticancer Res. 1999. PMID: 10625949 Review.
Inositol hexaphosphate (IP6) has a demonstrably effective anti-cancer action against a variety of experimental tumors. ...In rats, the urinary metabolites of IP6 are inositol and IP1. However, in humans 1-3% of total administered IP6 is excreted in the urine …
Inositol hexaphosphate (IP6) has a demonstrably effective anti-cancer action against a variety of experimental tumors. ...In rats, th …
Cellular and Molecular Activities of IP6 in Disease Prevention and Therapy.
Dilworth L, Stennett D, Omoruyi F. Dilworth L, et al. Biomolecules. 2023 Jun 10;13(6):972. doi: 10.3390/biom13060972. Biomolecules. 2023. PMID: 37371552 Free PMC article. Review.
IP6 (phytic acid) is a naturally occurring compound in plant seeds and grains. ...Additionally, it has been shown to have anti-mutagenic properties, which reduce the risk of malignancies by preventing DNA damage and mutations. IP6 has also been reported to have a po …
IP6 (phytic acid) is a naturally occurring compound in plant seeds and grains. ...Additionally, it has been shown to have anti-mutage …
HIV-1 is dependent on its immature lattice to recruit IP6 for mature capsid assembly.
Renner N, Kleinpeter A, Mallery DL, Albecka A, Rifat Faysal KM, Böcking T, Saiardi A, Freed EO, James LC. Renner N, et al. Nat Struct Mol Biol. 2023 Mar;30(3):370-382. doi: 10.1038/s41594-022-00887-4. Epub 2023 Jan 9. Nat Struct Mol Biol. 2023. PMID: 36624347 Free PMC article.
Here we show that the immature lattice is required to concentrate the cellular metabolite inositol hexakisphosphate (IP6) into virions to catalyze mature capsid assembly. Disabling the ability of HIV-1 to enrich IP6 does not prevent immature lattice formation or pro …
Here we show that the immature lattice is required to concentrate the cellular metabolite inositol hexakisphosphate (IP6) into virion …
Mammary tumor inhibition by IP6: a review.
Shamsuddin AM, Vucenik I. Shamsuddin AM, et al. Anticancer Res. 1999 Sep-Oct;19(5A):3671-4. Anticancer Res. 1999. PMID: 10625937 Review.
Could eating high fiber diet afford the same protection as IP6? Thus, we investigated whether dietary fiber containing high IP6 shows a dose-response inhibition of DMBA-induced rat mammary carcinogenesis, and if pure IP6 is more active as a cancer preventive …
Could eating high fiber diet afford the same protection as IP6? Thus, we investigated whether dietary fiber containing high IP6 …
786 results