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Page 1
Rivaroxaban in Rheumatic Heart Disease-Associated Atrial Fibrillation.
Connolly SJ, Karthikeyan G, Ntsekhe M, Haileamlak A, El Sayed A, El Ghamrawy A, Damasceno A, Avezum A, Dans AML, Gitura B, Hu D, Kamanzi ER, Maklady F, Fana G, Gonzalez-Hermosillo JA, Musuku J, Kazmi K, Zühlke L, Gondwe L, Ma C, Paniagua M, Ogah OS, Molefe-Baikai OJ, Lwabi P, Chillo P, Sharma SK, Cabral TTJ, Tarhuni WM, Benz A, van Eikels M, Krol A, Pattath D, Balasubramanian K, Rangarajan S, Ramasundarahettige C, Mayosi B, Yusuf S; INVICTUS Investigators. Connolly SJ, et al. N Engl J Med. 2022 Sep 15;387(11):978-988. doi: 10.1056/NEJMoa2209051. Epub 2022 Aug 28. N Engl J Med. 2022. PMID: 36036525 Clinical Trial.
Structural Characterization of a Neutralizing Nanobody With Broad Activity Against SARS-CoV-2 Variants.
Li T, Zhou B, Luo Z, Lai Y, Huang S, Zhou Y, Li Y, Gautam A, Bourgeau S, Wang S, Bao J, Tan J, Lavillette D, Li D. Li T, et al. Front Microbiol. 2022 Jun 2;13:875840. doi: 10.3389/fmicb.2022.875840. eCollection 2022. Front Microbiol. 2022. PMID: 35722331 Free PMC article.
Here, we report the isolation and biological and structural characterization of a single-chain antibody (nanobody) from RBD-immunized alpaca. The nanobody, named DL28, binds to RBD tightly with a K (D) of 1.56 nM and neutralizes the original SARS-CoV-2 strain with a …
Here, we report the isolation and biological and structural characterization of a single-chain antibody (nanobody) from RBD-immunized alpaca …
Chimeric antibody targeting unique epitope on onco-mucin16 reduces tumor burden in pancreatic and lung malignancies.
Shah A, Chaudhary S, Lakshmanan I, Aithal A, Kisling SG, Sorrell C, Marimuthu S, Gautam SK, Rauth S, Kshirsagar P, Cox JL, Natarajan G, Bhatia R, Mallya K, Rachagani S, Nasser MW, Ganti AK, Salgia R, Kumar S, Jain M, Ponnusamy MP, Batra SK. Shah A, et al. NPJ Precis Oncol. 2023 Aug 11;7(1):74. doi: 10.1038/s41698-023-00423-7. NPJ Precis Oncol. 2023. PMID: 37567918 Free PMC article.
Mitochondrial dysregulation occurs early in ALS motor cortex with TDP-43 pathology and suggests maintaining NAD+ balance as a therapeutic strategy.
Gautam M, Gunay A, Chandel NS, Ozdinler PH. Gautam M, et al. Sci Rep. 2022 Mar 11;12(1):4287. doi: 10.1038/s41598-022-08068-5. Sci Rep. 2022. PMID: 35277554 Free PMC article.
Since nicotinamide mononucleotide (NMN) was reported to restore NAD(+) levels, we next investigated whether NMN treatment would improve the health of diseased corticospinal motor neurons (CSMN, a.k.a. UMN in mice). prpTDP-43(A315T)-UeGFP mice, the CSMN reporter line …
Since nicotinamide mononucleotide (NMN) was reported to restore NAD(+) levels, we next investigated whether NMN treatment would improve the …
Cefpirome Treatment Results in Limited Selection of Stable Derepressed Enterobacter cloacae Mutants in the Intestinal Flora of Rats Treated for an Experimental Klebsiella pneumoniae Pulmonary Infection.
Gautam V, Mouton JW, Ten Kate MT, Bakker-Woudenberg IAJM, van Burgh S, Strepis N, Klaassen CHW, Goessens W. Gautam V, et al. Microb Drug Resist. 2020 Apr;26(4):341-348. doi: 10.1089/mdr.2018.0473. Epub 2019 Oct 29. Microb Drug Resist. 2020. PMID: 31657651
Objectives: We investigated the role of the administered cefpirome dose on the efficacy of treatment of a Klebsiella pneumoniae lung infection as well as in the selection of resistant Enterobacter cloacae isolates in the intestines of rats treated for a K. pneumonia …
Objectives: We investigated the role of the administered cefpirome dose on the efficacy of treatment of a Klebsiella pneumoniae lung infecti …
Development of a novel fluorogenic proteolytic beacon for in vivo detection and imaging of tumour-associated matrix metalloproteinase-7 activity.
McIntyre JO, Fingleton B, Wells KS, Piston DW, Lynch CC, Gautam S, Matrisian LM. McIntyre JO, et al. Biochem J. 2004 Feb 1;377(Pt 3):617-28. doi: 10.1042/BJ20030582. Biochem J. 2004. PMID: 14556651 Free PMC article.
PB-M7VIS is efficiently and selectively cleaved by MMP-7 with a k (cat)/ K (m) value of 1.9x10(5) M(-1).s(-1) as measured by the rate of increase in Fl fluorescence (up to 17-fold for the cleavage of an optimized PB-M7VIS) with minimal change in the TMR fluorescence …
PB-M7VIS is efficiently and selectively cleaved by MMP-7 with a k (cat)/ K (m) value of 1.9x10(5) M(-1).s(-1) as measured by t …
A machine learning-based approach to determine infection status in recipients of BBV152 (Covaxin) whole-virion inactivated SARS-CoV-2 vaccine for serological surveys.
Singh P, Ujjainiya R, Prakash S, Naushin S, Sardana V, Bhatheja N, Singh AP, Barman J, Kumar K, Gayali S, Khan R, Rawat BS, Tallapaka KB, Anumalla M, Lahiri A, Kar S, Bhosale V, Srivastava M, Mugale MN, Pandey CP, Khan S, Katiyar S, Raj D, Ishteyaque S, Khanka S, Rani A, Promila, Sharma J, Seth A, Dutta M, Saurabh N, Veerapandian M, Venkatachalam G, Bansal D, Gupta D, Halami PM, Peddha MS, Veeranna RP, Pal A, Singh RK, Anandasadagopan SK, Karuppanan P, Rahman SN, Selvakumar G, Venkatesan S, Karmakar MK, Sardana HK, Kothari A, Parihar DS, Thakur A, Saifi A, Gupta N, Singh Y, Reddu R, Gautam R, Mishra A, Mishra A, Gogeri I, Rayasam G, Padwad Y, Patial V, Hallan V, Singh D, Tirpude N, Chakrabarti P, Maity SK, Ganguly D, Sistla R, Balthu NK, A KK, Ranjith S, Kumar BV, Jamwal PS, Wali A, Ahmed S, Chouhan R, Gandhi SG, Sharma N, Rai G, Irshad F, Jamwal VL, Paddar MA, Khan SU, Malik F, Ghosh D, Thakkar G, Barik SK, Tripathi P, Satija YK, Mohanty S, Khan MT, Subudhi U, Sen P, Kumar R, Bhardwaj A, Gupta P, Sharma D, Tuli A, Ray Chaudhuri S, Krishnamurthi S, Prakash L, Rao CV, Singh BN, Chaurasiya A, Chaurasiyar M, Bhadange M, Likhitkar B, Mohite S, Patil Y, Kulkarni M, Joshi R, Pandya V, Ma… See abstract for full author list ➔ Singh P, et al. Comput Biol Med. 2022 Jul;146:105419. doi: 10.1016/j.compbiomed.2022.105419. Epub 2022 Apr 25. Comput Biol Med. 2022. PMID: 35483225 Free PMC article.
Cost-Effectiveness of Performing Reference Ultrasonography in Patients with Deep Vein Thrombosis.
de Jong CMM, van den Hout WB, van Dijk CE, Heim N, van Dam LF, Dronkers CEA, Gautam G, Ghanima W, Gleditsch J, von Heijne A, Hofstee HMA, Hovens MMC, Huisman MV, Kolman S, Mairuhu ATA, van Mens TE, Nijkeuter M, van de Ree MA, van Rooden CJ, Westerbeek RE, Westerink J, Westerlund E, Kroft LJM, Klok FA. de Jong CMM, et al. Thromb Haemost. 2023 Dec 27. doi: 10.1055/a-2213-9230. Online ahead of print. Thromb Haemost. 2023. PMID: 37984402
12 results