NF-κB is a critical mediator of post-mitotic senescence in oligodendrocytes and subsequent white matter loss.
Schlett JS, Mettang M, Skaf A, Schweizer P, Errerd A, Mulugeta EA, Hein TM, Tsesmelis K, Tsesmelis M, Büttner UFG, Wendt H, Abaei A, Rasche V, Prex V, Nespoli E, Alami NO, Tews D, Walther P, Yilmazer-Hanke D, Oswald F, Dimou L, Wirth T, Baumann B.
Schlett JS, et al.
Mol Neurodegener. 2023 Apr 17;18(1):24. doi: 10.1186/s13024-023-00616-5.
Mol Neurodegener. 2023.
PMID: 37069623
Free PMC article.
White matter degeneration (WMD), a well-known process in the aging brain, manifests in myelin loss finally resulting in motor, sensory and cognitive impairments. Oligodendrocytes (OL) are responsible for homeostasis and maintenance of the myelin sheaths, which is a complex …
White matter degeneration (WMD), a well-known process in the aging brain, manifests in myelin loss finally resulting in motor, sensor …