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A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease.
Keren-Shaul H, Spinrad A, Weiner A, Matcovitch-Natan O, Dvir-Szternfeld R, Ulland TK, David E, Baruch K, Lara-Astaiso D, Toth B, Itzkovitz S, Colonna M, Schwartz M, Amit I. Keren-Shaul H, et al. Among authors: spinrad a. Cell. 2017 Jun 15;169(7):1276-1290.e17. doi: 10.1016/j.cell.2017.05.018. Epub 2017 Jun 8. Cell. 2017. PMID: 28602351 Free article.
Microglia development follows a stepwise program to regulate brain homeostasis.
Matcovitch-Natan O, Winter DR, Giladi A, Vargas Aguilar S, Spinrad A, Sarrazin S, Ben-Yehuda H, David E, Zelada González F, Perrin P, Keren-Shaul H, Gury M, Lara-Astaiso D, Thaiss CA, Cohen M, Bahar Halpern K, Baruch K, Deczkowska A, Lorenzo-Vivas E, Itzkovitz S, Elinav E, Sieweke MH, Schwartz M, Amit I. Matcovitch-Natan O, et al. Among authors: spinrad a. Science. 2016 Aug 19;353(6301):aad8670. doi: 10.1126/science.aad8670. Epub 2016 Jun 23. Science. 2016. PMID: 27338705
Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner.
Deczkowska A, Matcovitch-Natan O, Tsitsou-Kampeli A, Ben-Hamo S, Dvir-Szternfeld R, Spinrad A, Singer O, David E, Winter DR, Smith LK, Kertser A, Baruch K, Rosenzweig N, Terem A, Prinz M, Villeda S, Citri A, Amit I, Schwartz M. Deczkowska A, et al. Among authors: spinrad a. Nat Commun. 2017 Sep 28;8(1):717. doi: 10.1038/s41467-017-00769-0. Nat Commun. 2017. PMID: 28959042 Free PMC article.