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1991 2
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Fluorimetric assays for N-acetylgalactosamine-6-sulfatase and arylsulfatase B based on the natural substrates for confirmation of mucopolysaccharidoses types IVA and VI.
Kumar AB, Spacil Z, Ghomashchi F, Masi S, Sumida T, Ito M, Turecek F, Scott CR, Gelb MH. Kumar AB, et al. Clin Chim Acta. 2015 Dec 7;451(Pt B):125-8. doi: 10.1016/j.cca.2015.08.010. Epub 2015 Aug 15. Clin Chim Acta. 2015. PMID: 26282597 Free PMC article.
METHODS: We developed new fluorimetric assays for N-acetylgalactosamine-6-sulfatase (GALNS) and arylsulfatase B (ARSB) based on the natural substrates, N-acetylgalactosamine-6-sulfate (and 4-sulfate), which have improved activity and specificity toward the relevant enzymes …
METHODS: We developed new fluorimetric assays for N-acetylgalactosamine-6-sulfatase (GALNS) and arylsulfatase B (ARSB) based on the n …
New substrates and enzyme assays for the detection of mucopolysaccharidosis III (Sanfilippo Syndrome) types A, B, C, and D by tandem mass spectrometry.
Wolfe BJ, Ghomashchi F, Kim T, Abam CA, Sadilek M, Jack R, Thompson JN, Scott CR, Gelb MH, Turecek F. Wolfe BJ, et al. Bioconjug Chem. 2012 Mar 21;23(3):557-64. doi: 10.1021/bc200609x. Epub 2012 Mar 9. Bioconjug Chem. 2012. PMID: 22372747 Free PMC article.
The clinical phenotype of Sanfilippo Syndrome is caused by one of four enzyme deficiencies that are associated with a defect in mucopolysaccharide metabolism. The four subtypes (A, B, C, and D) are each caused by an enzyme deficiency involved in the degradation of heparan …
The clinical phenotype of Sanfilippo Syndrome is caused by one of four enzyme deficiencies that are associated with a defect in mucopolysacc …
A protein geranylgeranyltransferase from bovine brain: implications for protein prenylation specificity.
Yokoyama K, Goodwin GW, Ghomashchi F, Glomset JA, Gelb MH. Yokoyama K, et al. Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5302-6. doi: 10.1073/pnas.88.12.5302. Proc Natl Acad Sci U S A. 1991. PMID: 2052607 Free PMC article.
Likewise, a peptide corresponding to the C terminus of human lamin B, a known farnesylated protein, selectively served as a substrate for farnesylation by the PFT. ...
Likewise, a peptide corresponding to the C terminus of human lamin B, a known farnesylated protein, selectively served as a substrate …
Groups IV, V, and X phospholipases A2s in human neutrophils: role in eicosanoid production and gram-negative bacterial phospholipid hydrolysis.
Degousee N, Ghomashchi F, Stefanski E, Singer A, Smart BP, Borregaard N, Reithmeier R, Lindsay TF, Lichtenberger C, Reinisch W, Lambeau G, Arm J, Tischfield J, Gelb MH, Rubin BB. Degousee N, et al. J Biol Chem. 2002 Feb 15;277(7):5061-73. doi: 10.1074/jbc.M109083200. Epub 2001 Dec 6. J Biol Chem. 2002. PMID: 11741884 Free article.
GV sPLA(2) does not contribute to fMLP-stimulated leukotriene B(4) production but may support the anti-bacterial properties of the neutrophil, because 10-100 ng per ml concentrations of this enzyme lead to Gram-negative bacterial membrane phospholipid hydrolysis in the pre …
GV sPLA(2) does not contribute to fMLP-stimulated leukotriene B(4) production but may support the anti-bacterial properties of the ne …
Cytosolic phospholipase A2-alpha is necessary for platelet-activating factor biosynthesis, efficient neutrophil-mediated bacterial killing, and the innate immune response to pulmonary infection: cPLA2-alpha does not regulate neutrophil NADPH oxidase activity.
Rubin BB, Downey GP, Koh A, Degousee N, Ghomashchi F, Nallan L, Stefanski E, Harkin DW, Sun C, Smart BP, Lindsay TF, Cherepanov V, Vachon E, Kelvin D, Sadilek M, Brown GE, Yaffe MB, Plumb J, Grinstein S, Glogauer M, Gelb MH. Rubin BB, et al. J Biol Chem. 2005 Mar 4;280(9):7519-29. doi: 10.1074/jbc.M407438200. Epub 2004 Oct 8. J Biol Chem. 2005. PMID: 15475363 Free PMC article.
In contrast, cPLA(2)-alpha inhibition or gene disruption diminished neutrophil-mediated E. coli killing in vitro, which was partially rescued by exogenous arachidonic acid or PAF but not leukotriene B(4). Following intratracheal inoculation with live E. coli in vivo, pulmo …
In contrast, cPLA(2)-alpha inhibition or gene disruption diminished neutrophil-mediated E. coli killing in vitro, which was partially rescue …
Kinetic characterization of phospholipase A2 modified by manoalogue.
Ghomashchi F, Yu BZ, Mihelich ED, Jain MK, Gelb MH. Ghomashchi F, et al. Biochemistry. 1991 Oct 8;30(40):9559-69. doi: 10.1021/bi00104a001. Biochemistry. 1991. PMID: 1911741
Manoalogue, a synthetic analogue of the sea sponge-derived manoalide, has been previously shown to partially inactivate the phospholipase A2 from cobra venom (Reynolds, L. J., Morgan, B. P., Hite, E. D., Mihelich, E. D., & Dennis, E. A. (1988) J. ...
Manoalogue, a synthetic analogue of the sea sponge-derived manoalide, has been previously shown to partially inactivate the phospholipase A2 …