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Page 1
Is perioperative COVID-19 really associated with worse surgical outcomes? A nationwide COVIDSurg propensity-matched analysis.
Argandykov D, Dorken-Gallastegi A, El Moheb M, Gebran A, Proaño-Zamudio JA, Bokenkamp M, Renne AM, Nepogodiev D, Bhangu A, Kaafarani HMA; COVIDSurg Collaborative. Argandykov D, et al. J Trauma Acute Care Surg. 2023 Apr 1;94(4):513-524. doi: 10.1097/TA.0000000000003859. Epub 2023 Jan 19. J Trauma Acute Care Surg. 2023. PMID: 36949053 Free PMC article.
MINCR is not a MYC-induced lncRNA.
Hart JR, Weinberg MS, Morris KV, Roberts TC, Janda KD, Garner AL, Vogt PK. Hart JR, et al. Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):E496-7. doi: 10.1073/pnas.1519903113. Epub 2016 Jan 25. Proc Natl Acad Sci U S A. 2016. PMID: 26811502 Free PMC article. No abstract available.
Translocation of c-myc in the hereditary renal cell carcinoma associated with a t(3;8)(p14.2;q24.13) chromosomal translocation.
Drabkin HA, Bradley C, Hart I, Bleskan J, Li FP, Patterson D. Drabkin HA, et al. Proc Natl Acad Sci U S A. 1985 Oct;82(20):6980-4. doi: 10.1073/pnas.82.20.6980. Proc Natl Acad Sci U S A. 1985. PMID: 2995998 Free PMC article.
Using somatic cell hybrids, we have isolated, separately, both derivative chromosomes. We find that the c-myc oncogene (8q24.1) has been translocated to the derivative 3 [der(3)]. We have not detected a rearrangement within an approximately equal to 21-kilobase region arou …
Using somatic cell hybrids, we have isolated, separately, both derivative chromosomes. We find that the c-myc oncogene (8q24.1) has b …
Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3Kα.
Liu X, Zhou Q, Hart JR, Xu Y, Yang S, Yang D, Vogt PK, Wang MW. Liu X, et al. Proc Natl Acad Sci U S A. 2022 Nov 16;119(46):e2215621119. doi: 10.1073/pnas.2215621119. Epub 2022 Nov 7. Proc Natl Acad Sci U S A. 2022. PMID: 36343266 Free PMC article.
About 80% of these mutations lead to single-amino-acid substitutions in one of three sites of p110alpha: two in the helical domain of the protein (E542K and E545K) and one at the C-terminus of the kinase domain (H1047R). Here, we report the cryo-electron microscopy structu …
About 80% of these mutations lead to single-amino-acid substitutions in one of three sites of p110alpha: two in the helical domain of the pr …
Glycosylation of the c-Myc transactivation domain.
Chou TY, Dang CV, Hart GW. Chou TY, et al. Proc Natl Acad Sci U S A. 1995 May 9;92(10):4417-21. doi: 10.1073/pnas.92.10.4417. Proc Natl Acad Sci U S A. 1995. PMID: 7753821 Free PMC article.
Here we present evidence for O-GlcNAc glycosylation of the oncoprotein c-Myc, a helix-loop-helix/leucine zipper phosphoprotein that heterodimerizes with Max and participates in the regulation of gene transcription in normal and neoplastic cells. ...Analyses of serial delet …
Here we present evidence for O-GlcNAc glycosylation of the oncoprotein c-Myc, a helix-loop-helix/leucine zipper phosphoprotein that h …
Cystatin C and the Risk of Frailty and Mortality in Older Men.
Hart A, Blackwell TL, Paudel ML, Taylor BC, Orwoll ES, Cawthon PM, Ensrud KE; Osteoporotic Fractures in Men (MrOS) Study Group. Hart A, et al. J Gerontol A Biol Sci Med Sci. 2017 Jul 1;72(7):965-970. doi: 10.1093/gerona/glw223. J Gerontol A Biol Sci Med Sci. 2017. PMID: 28329858 Free PMC article.
BACKGROUND: This study examines the association between cystatin C (cysC) levels and risks of progression of frailty status or death in older men. ...
BACKGROUND: This study examines the association between cystatin C (cysC) levels and risks of progression of frailty status or death …
Integrative geochronology calibrates the Middle and Late Stone Ages of Ethiopia's Afar Rift.
Niespolo EM, WoldeGabriel G, Hart WK, Renne PR, Sharp WD, Shackley MS, Ambrose SH, Asfaw B, Beyene Y, Brasil MF, Carlson JP, Sahle Y, White TD. Niespolo EM, et al. Proc Natl Acad Sci U S A. 2021 Dec 14;118(50):e2116329118. doi: 10.1073/pnas.2116329118. Proc Natl Acad Sci U S A. 2021. PMID: 34873047 Free PMC article.
We apply the recently developed (230)Th/U burial dating of OES to bridge the temporal gap between radiocarbon ((14)C) and (40)Ar/(39)Ar ages for the MSA and provide (14)C ages to constrain the younger LSA archaeology and fauna to 24 to 21.4 ka. Paired (14)C a …
We apply the recently developed (230)Th/U burial dating of OES to bridge the temporal gap between radiocarbon ((14)C) and (40)Ar/(39) …
Substrate binding to BamD triggers a conformational change in BamA to control membrane insertion.
Lee J, Sutterlin HA, Wzorek JS, Mandler MD, Hagan CL, Grabowicz M, Tomasek D, May MD, Hart EM, Silhavy TJ, Kahne D. Lee J, et al. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2359-2364. doi: 10.1073/pnas.1711727115. Epub 2018 Feb 20. Proc Natl Acad Sci U S A. 2018. PMID: 29463713 Free PMC article.
To elucidate aspects of this process we slowed the assembly of an essential beta-barrel substrate of the Bam complex, LptD, by changing a conserved residue near the C terminus. This defective substrate is recruited to the Bam complex via BamD but is unable to integrate int …
To elucidate aspects of this process we slowed the assembly of an essential beta-barrel substrate of the Bam complex, LptD, by changing a co …
Structure of CARDS toxin, a unique ADP-ribosylating and vacuolating cytotoxin from Mycoplasma pneumoniae.
Becker A, Kannan TR, Taylor AB, Pakhomova ON, Zhang Y, Somarajan SR, Galaleldeen A, Holloway SP, Baseman JB, Hart PJ. Becker A, et al. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5165-70. doi: 10.1073/pnas.1420308112. Epub 2015 Apr 6. Proc Natl Acad Sci U S A. 2015. PMID: 25848012 Free PMC article.
Here we present the structure of CARDS TX, a triangular molecule in which N-terminal mART and C-terminal tandem beta-trefoil domains associate to form an overall architecture distinct from other well-recognized ADP-ribosylating bacterial toxins. We demonstrate that CARDS T …
Here we present the structure of CARDS TX, a triangular molecule in which N-terminal mART and C-terminal tandem beta-trefoil domains …
Inhibitor of MYC identified in a Kröhnke pyridine library.
Hart JR, Garner AL, Yu J, Ito Y, Sun M, Ueno L, Rhee JK, Baksh MM, Stefan E, Hartl M, Bister K, Vogt PK, Janda KD. Hart JR, et al. Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12556-61. doi: 10.1073/pnas.1319488111. Epub 2014 Aug 11. Proc Natl Acad Sci U S A. 2014. PMID: 25114221 Free PMC article.
55 results