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Progress towards clinically useful aldosterone synthase inhibitors.

Cerny MA. Cerny MA. Curr Top Med Chem. 2013;13(12):1385-401. doi: 10.2174/1568026611313120003. Curr Top Med Chem. 2013. PMID: 23688131 Review.

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Effective Application of Metabolite Profiling in Drug Design and Discovery.

Cerny MA, Kalgutkar AS, Obach RS, Sharma R, Spracklin DK, Walker GS. Cerny MA, et al. J Med Chem. 2020 Jun 25;63(12):6387-6406. doi: 10.1021/acs.jmedchem.9b01840. Epub 2020 Mar 6. J Med Chem. 2020. PMID: 32097005

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Identification of Glycochenodeoxycholate 3-O-Glucuronide and Glycodeoxycholate 3-O-Glucuronide as Highly Sensitive and Specific OATP1B1 Biomarkers.

Neuvonen M, Hirvensalo P, Tornio A, Rago B, West M, Lazzaro S, Mathialagan S, Varma M, Cerny MA, Costales C, Ramanathan R, Rodrigues AD, Niemi M. Neuvonen M, et al. Among authors: cerny ma. Clin Pharmacol Ther. 2021 Mar;109(3):646-657. doi: 10.1002/cpt.2053. Epub 2020 Oct 18. Clin Pharmacol Ther. 2021. PMID: 32961594 Free PMC article.

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Prevalence of Non-Cytochrome P450-Mediated Metabolism in Food and Drug Administration-Approved Oral and Intravenous Drugs: 2006-2015.

Cerny MA. Cerny MA. Drug Metab Dispos. 2016 Aug;44(8):1246-52. doi: 10.1124/dmd.116.070763. Epub 2016 Apr 15. Drug Metab Dispos. 2016. PMID: 27084892 Review.

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Static and Dynamic Projections of Drug-Drug Interactions Caused by Cytochrome P450 3A Time-Dependent Inhibitors Measured in Human Liver Microsomes and Hepatocytes.

Tseng E, Eng H, Lin J, Cerny MA, Tess DA, Goosen TC, Obach RS. Tseng E, et al. Among authors: cerny ma. Drug Metab Dispos. 2021 Oct;49(10):947-960. doi: 10.1124/dmd.121.000497. Epub 2021 Jul 29. Drug Metab Dispos. 2021. PMID: 34326140

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Identification and Characterization of a Selective Human Carbonyl Reductase 1 Substrate.

Ramsden D, Smith D, Arenas R, Frederick K, Cerny MA. Ramsden D, et al. Among authors: cerny ma. Drug Metab Dispos. 2018 Oct;46(10):1434-1440. doi: 10.1124/dmd.118.082487. Epub 2018 Aug 1. Drug Metab Dispos. 2018. PMID: 30068520

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Identification of Human Sulfotransferases Involved in Lorcaserin N-Sulfamate Formation.

Sadeque AJ, Palamar S, Usmani KA, Chen C, Cerny MA, Chen WG. Sadeque AJ, et al. Among authors: cerny ma. Drug Metab Dispos. 2016 Apr;44(4):570-5. doi: 10.1124/dmd.115.067397. Epub 2016 Jan 12. Drug Metab Dispos. 2016. PMID: 26758853

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Dihydrobenzisoxazole-4-one compounds are novel selective inhibitors of aldosterone synthase (CYP11B2) with in vivo activity.

Meyers K, Cogan DA, Burke J, Arenas R, Balestra M, Brown NF, Chen Z, Cerny MA, Clifford HE, Colombo F, Fader L, Frederick KS, Guo X, Goldberg D, Hornberger KR, Kugler S, Lord J, Marshall DR, Moss N, Parmentier JH, Richman JR, Schmenk J, Weldon SM, Yu M, Zhang M. Meyers K, et al. Among authors: cerny ma. Bioorg Med Chem Lett. 2018 Mar 1;28(5):979-984. doi: 10.1016/j.bmcl.2017.12.015. Epub 2017 Dec 8. Bioorg Med Chem Lett. 2018. PMID: 29254646

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Cytochrome P450 3A Time-Dependent Inhibition Assays Are Too Sensitive for Identification of Drugs Causing Clinically Significant Drug-Drug Interactions: A Comparison of Human Liver Microsomes and Hepatocytes and Definition of Boundaries for Inactivation Rate Constants.

Eng H, Tseng E, Cerny MA, Goosen TC, Obach RS. Eng H, et al. Among authors: cerny ma. Drug Metab Dispos. 2020 Jun;49(6):442-450. doi: 10.1124/dmd.121.000356. Epub 2021 Apr 2. Drug Metab Dispos. 2020. PMID: 33811106

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Identification of human UDP-glucuronosyltransferases involved in N-carbamoyl glucuronidation of lorcaserin.

Sadeque AJ, Usmani KA, Palamar S, Cerny MA, Chen WG. Sadeque AJ, et al. Among authors: cerny ma. Drug Metab Dispos. 2012 Apr;40(4):772-8. doi: 10.1124/dmd.111.043448. Epub 2012 Jan 18. Drug Metab Dispos. 2012. PMID: 22259019

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