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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 1
1972 1
1975 2
1976 2
1978 1
1979 1
1981 2
1982 1
1983 1
1984 1
1985 1
1986 3
1987 6
1988 3
1989 8
1990 5
1991 4
1992 9
1993 4
1994 11
1995 7
1996 12
1997 5
1998 5
1999 7
2000 12
2001 21
2002 11
2003 24
2004 17
2005 26
2006 35
2007 40
2008 44
2009 28
2010 52
2011 50
2012 48
2013 67
2014 95
2015 114
2016 137
2017 155
2018 153
2019 145
2020 150
2021 199
2022 179
2023 186
2024 54

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1,931 results

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Page 1
Irritable bowel syndrome: pathogenesis, diagnosis, treatment, and evidence-based medicine.
Saha L. Saha L. World J Gastroenterol. 2014 Jun 14;20(22):6759-73. doi: 10.3748/wjg.v20.i22.6759. World J Gastroenterol. 2014. PMID: 24944467 Free PMC article. Review.
According to the updated ROME III criteria, IBS is a clinical diagnosis and presents as one of the three predominant subtypes: (1) IBS with constipation (IBS-C); (2) IBS with diarrhea (IBS-D); and (3) mixed IBS (IBS-M); former ROME definitions refer to IBS-M as alternating …
According to the updated ROME III criteria, IBS is a clinical diagnosis and presents as one of the three predominant subtypes: (1) IBS with …
SAHA Alleviates Diarrhea-Predominant Irritable Bowel Syndrome Through Regulation of the p-STAT3/SERT/5-HT Signaling Pathway.
Shen J, Zhang B, Chen J, Cheng J, Wang J, Zheng X, Lan Y, Zhang X. Shen J, et al. J Inflamm Res. 2022 Mar 10;15:1745-1756. doi: 10.2147/JIR.S331303. eCollection 2022. J Inflamm Res. 2022. PMID: 35300211 Free PMC article.
The treatment also elevated the expression of signal transducer and activator for transcription 3 (STAT3) and SERT. Activation of p-STAT3 may reverse the inhibitory effect of SAHA on the elevated visceral sensitivity of D-IBS model rats. Moreover, SAHA promot …
The treatment also elevated the expression of signal transducer and activator for transcription 3 (STAT3) and SERT. Activation of p-STAT3 ma …
Vitamin D in thyroid tumorigenesis and development.
Clinckspoor I, Verlinden L, Mathieu C, Bouillon R, Verstuyf A, Decallonne B. Clinckspoor I, et al. Prog Histochem Cytochem. 2013 Aug;48(2):65-98. doi: 10.1016/j.proghi.2013.07.001. Epub 2013 Jul 26. Prog Histochem Cytochem. 2013. PMID: 23890557 Review.
Besides its classical role in bone and calcium homeostasis, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), the active form of vitamin D, has many non-classical effects; antiproliferative, anti-apoptotic and prodifferentiating effects of 1,25(OH)2D3 have been described in several …
Besides its classical role in bone and calcium homeostasis, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), the active form of vitamin D, has …
Unified D-alpha-Tocopherol 5-Fu/SAHA bioconjugates self-assemble as complex nanodrug for optimized combination therapy.
Han L, Wang T, Mu S, Yin X, Liang S, Fang H, Liu Y, Zhang N. Han L, et al. Nanomedicine (Lond). 2018 Jun;13(11):1285-1301. doi: 10.2217/nnm-2017-0316. Nanomedicine (Lond). 2018. PMID: 29949468
AIM: To optimize the synergistic efficacy of combination therapy with controlled molar ratio, complex small molecule-based nanodrug (Co-SMND) of 5-fluorouracil (5-Fu)/vorinostat (SAHA) was developed. MATERIALS & METHODS: Co-SMND with various ratios of 5-Fu-D-alp …
AIM: To optimize the synergistic efficacy of combination therapy with controlled molar ratio, complex small molecule-based nanodrug (Co-SMND …
Dibenzoheterole-Fused s-Indacenes.
Saha HK, Mallick D, Das S. Saha HK, et al. J Org Chem. 2023 Dec 1;88(23):16248-16258. doi: 10.1021/acs.joc.3c01719. Epub 2023 Nov 9. J Org Chem. 2023. PMID: 37943573
However, the outcome of the antiaromatic properties for dibenzoheterole-fused s-indacene antiaromatics remained underexplored. Carbazole-, dibenzothiophene-, dibenzofuran-, and dibenzo[b,d]thiophene-5,5-dioxide-fused s-indacenes 1-4, respectively, were synthesized and char …
However, the outcome of the antiaromatic properties for dibenzoheterole-fused s-indacene antiaromatics remained underexplored. Carbazole-, d …
Renin-Angiotensin System and Cardiovascular Functions.
Wu CH, Mohammadmoradi S, Chen JZ, Sawada H, Daugherty A, Lu HS. Wu CH, et al. Arterioscler Thromb Vasc Biol. 2018 Jul;38(7):e108-e116. doi: 10.1161/ATVBAHA.118.311282. Arterioscler Thromb Vasc Biol. 2018. PMID: 29950386 Free PMC article. Review. No abstract available.
Effect of low doses of actinomycin D on neuroblastoma cell lines.
Cortes CL, Veiga SR, Almacellas E, Hernández-Losa J, Ferreres JC, Kozma SC, Ambrosio S, Thomas G, Tauler A. Cortes CL, et al. Mol Cancer. 2016 Jan 4;15:1. doi: 10.1186/s12943-015-0489-8. Mol Cancer. 2016. PMID: 26728659 Free PMC article.
We also determined whether actinomycin D could increase the efficacy of the histone deacetylase inhibitor, SAHA, which is in being used in neuroblastoma clinical trials. We show that actinomycin D synergizes with SAHA in neuroblastoma cell lines. Moreo …
We also determined whether actinomycin D could increase the efficacy of the histone deacetylase inhibitor, SAHA, which is in b …
Diagnosis of arsenicosis.
Saha KC. Saha KC. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2003 Jan;38(1):255-72. doi: 10.1081/ese-120016893. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2003. PMID: 12635831 Review.
Diagnosis of arsenicosis was derived by chronological establishment of facts: (a) arsenic as the cause of malady, (b) drinking water (tubewell water) as the vehicle of arsenic, (c) soil as the source of arsenic, (d) mechanism of leaching of arsenic from soil, and (e) cause …
Diagnosis of arsenicosis was derived by chronological establishment of facts: (a) arsenic as the cause of malady, (b) drinking water (tubewe …
Histone deacetylase inhibitors.
Monneret C. Monneret C. Eur J Med Chem. 2005 Jan;40(1):1-13. doi: 10.1016/j.ejmech.2004.10.001. Eur J Med Chem. 2005. PMID: 15642405 Review.
Except depsispeptide FK228, natural HDACs (trichostatin (TSA), depudecin, trapoxins, apicidins) as well as sodium butyrate, phenylbutyrate and suberoyl anilide hydroxamic acid (SAHA), while effective in vivo, are inefficient due to instability and low retention. Subsequent …
Except depsispeptide FK228, natural HDACs (trichostatin (TSA), depudecin, trapoxins, apicidins) as well as sodium butyrate, phenylbutyrate a …
1,931 results