Siponimod ameliorates metabolic oligodendrocyte injury via the sphingosine-1 phosphate receptor 5.
Behrangi N, Heinig L, Frintrop L, Santrau E, Kurth J, Krause B, Atanasova D, Clarner T, Fragoulis A, Joksch M, Rudolf H, Meuth SG, Joost S, Kipp M.
Behrangi N, et al.
Proc Natl Acad Sci U S A. 2022 Oct 4;119(40):e2204509119. doi: 10.1073/pnas.2204509119. Epub 2022 Sep 26.
Proc Natl Acad Sci U S A. 2022.
PMID: 36161894
Free PMC article.
In this project, we followed the hypothesis that siponimod, a sphingosine-1 phosphate receptor modulator, exerts protective effects by direct modulation of glia cell function (i.e., either astrocytes, microglia, or oligodendrocytes). To this end, we used the toxin-mediated …
In this project, we followed the hypothesis that siponimod, a sphingosine-1 phosphate receptor modulator, exerts protective effects by direc …