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Identifying gene-environment interactions in schizophrenia: contemporary challenges for integrated, large-scale investigations.
European Network of National Networks studying Gene-Environment Interactions in Schizophrenia (EU-GEI); van Os J, Rutten BP, Myin-Germeys I, Delespaul P, Viechtbauer W, van Zelst C, Bruggeman R, Reininghaus U, Morgan C, Murray RM, Di Forti M, McGuire P, Valmaggia LR, Kempton MJ, Gayer-Anderson C, Hubbard K, Beards S, Stilo SA, Onyejiaka A, Bourque F, Modinos G, Tognin S, Calem M, O'Donovan MC, Owen MJ, Holmans P, Williams N, Craddock N, Richards A, Humphreys I, Meyer-Lindenberg A, Leweke FM, Tost H, Akdeniz C, Rohleder C, Bumb JM, Schwarz E, Alptekin K, Üçok A, Saka MC, Atbaşoğlu EC, Gülöksüz S, Gumus-Akay G, Cihan B, Karadağ H, Soygür H, Cankurtaran EŞ, Ulusoy S, Akdede B, Binbay T, Ayer A, Noyan H, Karadayı G, Akturan E, Ulaş H, Arango C, Parellada M, Bernardo M, Sanjuán J, Bobes J, Arrojo M, Santos JL, Cuadrado P, Rodríguez Solano JJ, Carracedo A, García Bernardo E, Roldán L, López G, Cabrera B, Cruz S, Díaz Mesa EM, Pouso M, Jiménez E, Sánchez T, Rapado M, González E, Martínez C, Sánchez E, Olmeda MS, de Haan L, Velthorst E, van der Gaag M, Selten JP, van Dam D, van der Ven E, van der Meer F, Messchaert E, Kraan T, Burger N, Leboyer M, Szoke A, Schürhoff F, Llorca PM, Jamain S… See abstract for full author list ➔ European Network of National Networks studying Gene-Environment Interactions in Schizophrenia (EU-GEI), et al. Schizophr Bull. 2014 Jul;40(4):729-36. doi: 10.1093/schbul/sbu069. Epub 2014 May 24. Schizophr Bull. 2014. PMID: 24860087 Free PMC article. Review.
There are now also a limited number of studies that have investigated molecular genetic candidate gene-environment interactions (G E), however, so far, thorough replication of findings is rare and G E research still faces several conceptual and methodological challe …
There are now also a limited number of studies that have investigated molecular genetic candidate gene-environment interactions (G E) …
Practical issues with amisulpride in the management of patients with schizophrenia.
Pani L, Villagrán JM, Kontaxakis VP, Alptekin K. Pani L, et al. Clin Drug Investig. 2008;28(8):465-77. doi: 10.2165/00044011-200828080-00001. Clin Drug Investig. 2008. PMID: 18598092 Review.
Amisulpride has a low risk of drug-drug interactions, and, during cross-tapering, patients can remain on concurrent treatments (e.g. anticholinergics and antiparkinsonian agents) until the effective dosage has been reached. ...
Amisulpride has a low risk of drug-drug interactions, and, during cross-tapering, patients can remain on concurrent treatments (e.g. …
Effects of a cyclic NSAID regimen on levels of gingival crevicular fluid prostaglandin E(2)and Interleukin-1beta: A 6-month randomized controlled clinical trial.
Oduncuoglu BF, Kayar NA, Haliloglu S, Serpek B, Ataoglu T, Alptekin NO. Oduncuoglu BF, et al. Niger J Clin Pract. 2018 May;21(5):658-666. doi: 10.4103/njcp.njcp_221_17. Niger J Clin Pract. 2018. PMID: 29735869 Clinical Trial.
We evaluated the effect of a cyclic diclofenac potassium (DP) regimen on clinical parameters and levels of prostaglandin E(2) (PGE(2)) and interleukin-1beta (IL-1beta) in the gingival crevicular fluid (GCF) of individuals with periodontitis. ...
We evaluated the effect of a cyclic diclofenac potassium (DP) regimen on clinical parameters and levels of prostaglandin E(2) (PGE(2) …
Neurocognitive functioning during symptomatic states and remission in bipolar disorder and schizophrenia: A comparative study.
Ceylan D, Akdede BB, Bora E, Aktener AY, Hıdıroğlu Ongun C, Tunca Z, Alptekin K, Özerdem A. Ceylan D, et al. Psychiatry Res. 2020 Oct;292:113292. doi: 10.1016/j.psychres.2020.113292. Epub 2020 Jul 15. Psychiatry Res. 2020. PMID: 32707217
Conclusion Our data suggest that both disorders are associated with state dependent (i.e., global cognition and working memory) and diagnosis dependent (i.e., global cognition and verbal fluency) neurocognitive dysfunctions. ...
Conclusion Our data suggest that both disorders are associated with state dependent (i.e., global cognition and working memory) and d …
A Comprehensive Framework for Measuring the Immediate Impact of TV Advertisements: TV-Impact.
Arslan A, Tecimer K, Turgut H, Bali Ö, Yücel A, Alptekin GI, Orman GK. Arslan A, et al. Entropy (Basel). 2024 Jan 25;26(2):109. doi: 10.3390/e26020109. Entropy (Basel). 2024. PMID: 38392364 Free PMC article.
Existing studies have either determined how a specific focus group, i.e., toddlers, people of a certain age group, etc., react to ads via simple statistical tests using a case study approach or have examined the effects of advertising with simple regression models. ...
Existing studies have either determined how a specific focus group, i.e., toddlers, people of a certain age group, etc., react to ads …
Burnout in Chest Physicians after Health Care Reforms: A Cross-Sectional Study in Turkey.
Atik M, Uçan ES, Ellidokuz H, Alptekin K. Atik M, et al. Turk Thorac J. 2019 Jan 1;20(1):18-24. doi: 10.5152/TurkThoracJ.2018.18041. Turk Thorac J. 2019. PMID: 30664422 Free PMC article.
Between September and November 2016, chest physicians were reached with permissions by expertise associations via e-mail groups. A sample size of 352 physicians was included in the study out of 2,349 chest physicians in Turkey. ...
Between September and November 2016, chest physicians were reached with permissions by expertise associations via e-mail groups. A sa …
Comparison of 12-Week Fitness Protocols Following Bariatric Surgery: Aerobic Exercise Versus Aerobic Exercise and Progressive Resistance.
In G, Taskin HE, Al M, Alptekin HK, Zengin K, Yumuk V, Ikitimur B. In G, et al. Obes Surg. 2021 Apr;31(4):1475-1484. doi: 10.1007/s11695-020-05144-5. Epub 2021 Jan 6. Obes Surg. 2021. PMID: 33409974
Anthropometric characteristic changes were recorded, as well as changes in functional capacity (e.g., 6-min walking test), muscle strength (e.g., hand grip strength test; five-times-sit-to-stand test), and quality of life (i.e., Beck Depression Inventory). .. …
Anthropometric characteristic changes were recorded, as well as changes in functional capacity (e.g., 6-min walking test), muscle str …
Cognitive functioning throughout adulthood and illness stages in individuals with psychotic disorders and their unaffected siblings.
Velthorst E, Mollon J, Murray RM, de Haan L, Germeys IM, Glahn DC, Arango C, van der Ven E, Di Forti M, Bernardo M, Guloksuz S, Delespaul P, Mezquida G, Amoretti S, Bobes J, Saiz PA, García-Portilla MP, Santos JL, Jiménez-López E, Sanjuan J, Aguilar EJ, Arrojo M, Carracedo A, López G, González-Peñas J, Parellada M, Atbaşoğlu C, Saka MC, Üçok A, Alptekin K, Akdede B, Binbay T, Altınyazar V, Ulaş H, Yalınçetin B, Gümüş-Akay G, Beyaz BC, Soygür H, Cankurtaran EŞ, Kaymak SU, Maric NP, Mihaljevic MM, Petrovic SA, Mirjanic T, Del-Ben CM, Ferraro L, Gayer-Anderson C, Jones PB, Jongsma HE, Kirkbride JB, La Cascia C, Lasalvia A, Tosato S, Llorca PM, Menezes PR, Morgan C, Quattrone D, Menchetti M, Selten JP, Szöke A, Tarricone I, Tortelli A, McGuire P, Valmaggia L, Kempton MJ, van der Gaag M, Riecher-Rössler A, Bressan RA, Barrantes-Vidal N, Nelson B, McGorry P, Pantelis C, Krebs MO, Ruhrmann S, Sachs G, Rutten BPF, van Os J, Alizadeh BZ, van Amelsvoort T, Bartels-Velthuis AA, Bruggeman R, van Beveren NJ, Luykx JJ, Cahn W, Simons CJP, Kahn RS, Schirmbeck F, van Winkel R; EU-GEI High Risk Study; Reichenberg A. Velthorst E, et al. Mol Psychiatry. 2021 Aug;26(8):4529-4543. doi: 10.1038/s41380-020-00969-z. Epub 2021 Jan 7. Mol Psychiatry. 2021. PMID: 33414498
Deficits in verbal knowledge, and working memory may specifically index familial, i.e., shared genetic and/or shared environmental, liability for psychotic disorders. ...
Deficits in verbal knowledge, and working memory may specifically index familial, i.e., shared genetic and/or shared environmental, l …
Psychometric liability to psychosis and childhood adversities are associated with shorter telomere length: A study on schizophrenia patients, unaffected siblings, and non-clinical controls.
Çevik B, Mançe-Çalışır Ö, Atbaşoğlu EC, Saka MC, Alptekin K, Üçok A, Sırmatel B, Gülöksüz S, Tükün A, van Os J, Gümüş-Akay G. Çevik B, et al. J Psychiatr Res. 2019 Apr;111:169-185. doi: 10.1016/j.jpsychires.2019.01.022. Epub 2019 Feb 8. J Psychiatr Res. 2019. PMID: 30776705
Our additional goals were to determine (1) whether shorter TL correlates with intermediate phenotypes of SCZ (i.e. Psychosis-like symptoms and schizotypal traits); and (2) whether childhood adversities have a moderating role in TL shortening among SCZ and their unaffected …
Our additional goals were to determine (1) whether shorter TL correlates with intermediate phenotypes of SCZ (i.e. Psychosis-like sym …
Effects of quetiapine on cognitive functions in schizophrenia.
Kivircik Akdede BB, Alptekin K, Kitiş A, Arkar H, Akvardar Y. Kivircik Akdede BB, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Feb;29(2):233-8. doi: 10.1016/j.pnpbp.2004.11.005. Epub 2004 Dec 24. Prog Neuropsychopharmacol Biol Psychiatry. 2005. PMID: 15694229 Clinical Trial.
OBJECTIVE: All atypical antipsychotic drugs with complex pharmacology have been shown to improve some, but not all, domains of cognitive function, including quetiapine, i.e., the agent with the most rapid dissociation from dopamine receptors and a relatively weak serotonin …
OBJECTIVE: All atypical antipsychotic drugs with complex pharmacology have been shown to improve some, but not all, domains of cognitive fun …
24 results