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Engineered anti-EGFRvIII targeted exosomes induce apoptosis in glioblastoma multiforme.
Rahmani R, Kiani J, Tong WY, Soleimani M, Voelcker NH, Arefian E. Rahmani R, et al. J Drug Target. 2023 Mar;31(3):310-319. doi: 10.1080/1061186X.2022.2152819. Epub 2022 Dec 12. J Drug Target. 2023. PMID: 36440540
METHODS: In this study, mesenchymal stem cells (MSCs) were engineered to produce exosomes, i.e. nanosized natural vesicles presenting anti-EGFRvIII (ab139) antibody on their surface while encapsulating two apoptosis-inducing gene therapy agents, i.e. cytosine deamin …
METHODS: In this study, mesenchymal stem cells (MSCs) were engineered to produce exosomes, i.e. nanosized natural vesicles presenting …
Basic Characteristics of Oligodendrogliomas at the Shohada-e Tajrish Hospital (2008 to 2014).
Ahadi M, Moradi A, Rakhshan A, Arefian A, Rafizadeh M, Zham H. Ahadi M, et al. Iran J Pathol. 2017 Summer;12(3):241-247. Epub 2017 Jul 1. Iran J Pathol. 2017. PMID: 29531549 Free PMC article.
METHODS: In this descriptive retrospective study, patients with definite diagnosis of oligodendroglioma were identified by reviewing the archives of pathology reports at the department of pathology of Shohada-e Tajrish Hospital during years 2008 to 2014. Age, gender, locat …
METHODS: In this descriptive retrospective study, patients with definite diagnosis of oligodendroglioma were identified by reviewing the arc …
Mir-122 upregulation and let-7f downregulation combination: The effects on hepatic differentiation of hiPSCs on the PCL-Gel-HA nanofibrous scaffold.
Parvanak M, Mostafavi-Pour Z, Soleimani M, Atashi A, Arefian E, Esmaeili E. Parvanak M, et al. J Cell Mol Med. 2022 Oct;26(20):5235-5245. doi: 10.1111/jcmm.17552. Epub 2022 Sep 13. J Cell Mol Med. 2022. PMID: 36098216 Free PMC article.
We transduced human iPSCs (hiPSCs) with miR-122 and off-let-7f (hiPSCs(miR-122 + off-let-7f) ) to evaluate how they can differentiate hiPSCs to hepatocyte-like cells (HLCs) without any extrinsic growth factor. Additionally, we studied the effect of Poly e-caprolactone-gela …
We transduced human iPSCs (hiPSCs) with miR-122 and off-let-7f (hiPSCs(miR-122 + off-let-7f) ) to evaluate how they can differentiate hiPSCs …
Inhibitory effect of flavonoid xanthomicrol on triple-negative breast tumor via regulation of cancer-associated microRNAs.
Attari F, Keighobadi F, Abdollahi M, Arefian E, Lotfizadeh R, Sepehri H, Moridi Farimani M. Attari F, et al. Phytother Res. 2021 Apr;35(4):1967-1982. doi: 10.1002/ptr.6940. Epub 2020 Nov 20. Phytother Res. 2021. PMID: 33217075
In the present study, we have investigated the anticancer effects of flavonoid xanthomicrol on the mice breast cancer model using MTT assay, cell cycle and Annexin/PI analysis, colony formation assay, H&E staining, immunohistochemistry, and miRNA analysis. Our results …
In the present study, we have investigated the anticancer effects of flavonoid xanthomicrol on the mice breast cancer model using MTT assay, …
Finding Appropriate Signal Peptides for Secretory Production of Recombinant Glucarpidase: An In SilicoMethod.
Vakili O, Khatami SH, Maleksabet A, Movahedpour A, Fana SE, Sadegh R, Salmanzadeh AH, Razeghifam H, Nourdideh S, Tehrani SS, Taheri-Anganeh M. Vakili O, et al. Recent Pat Biotechnol. 2021;15(4):302-315. doi: 10.2174/1872208315666210921095420. Recent Pat Biotechnol. 2021. PMID: 34547999
The recombinant form of glucarpidase is produced by engineered E. coli and is a confirmed choice to overcoming this problem. OBJECTIVE: In the present study, in silico analyses were performed to select suitable SPs for the secretion of recombinant glucarpidase in E. …
The recombinant form of glucarpidase is produced by engineered E. coli and is a confirmed choice to overcoming this problem. OBJECTIV …
Decellularized Pancreas Matrix Scaffolds for Tissue Engineering Using Ductal or Arterial Catheterization.
Hashemi J, Pasalar P, Soleimani M, Arefian E, Khorramirouz R, Akbarzadeh A, Ghorbani F, Enderami SE, Kajbafzadeh AM. Hashemi J, et al. Cells Tissues Organs. 2018;205(2):72-84. doi: 10.1159/000487230. Epub 2018 May 9. Cells Tissues Organs. 2018. PMID: 29742511
RESULTS: High concentrations of sodium dodecyl sulfate (SDS), i.e., > 0.05%, resulted in tissue disruption or incomplete cell removal depending on the duration of exposure. ...
RESULTS: High concentrations of sodium dodecyl sulfate (SDS), i.e., > 0.05%, resulted in tissue disruption or incomplete cell remo …
Inhibitory effect of miR342 on the progression of triple-negative breast cancer cells in vitro and in the mice model.
Alidoost Z, Attari F, Saadatpour F, Arefian E. Alidoost Z, et al. Bioimpacts. 2024;14(1):27758. doi: 10.34172/bi.2023.27758. Epub 2023 Oct 7. Bioimpacts. 2024. PMID: 38327636 Free PMC article.
Apoptosis and invasion rates were respectively evaluated by annexin/7-AAD and wound healing assays. At last, in vivo tumor progression was evaluated using H&E staining, real-time PCR, and immunohistochemistry. RESULTS: The viability of transduced-4T1 cells reduced sign …
Apoptosis and invasion rates were respectively evaluated by annexin/7-AAD and wound healing assays. At last, in vivo tumor progression was e …
MicroRNA-340 inhibits the migration, invasion, and metastasis of breast cancer cells by targeting Wnt pathway.
Mohammadi-Yeganeh S, Paryan M, Arefian E, Vasei M, Ghanbarian H, Mahdian R, Karimipoor M, Soleimani M. Mohammadi-Yeganeh S, et al. Tumour Biol. 2016 Jul;37(7):8993-9000. doi: 10.1007/s13277-015-4513-9. Epub 2016 Jan 12. Tumour Biol. 2016. PMID: 26758430
By bioinformatic analysis, we confirmed the important role of miR-340 as a pivotal regulator of breast cancer metastasis in targeting previously validated (ROCK1) and potentially novel genes, i.e., (CTNNB1 and c-MYC)....
By bioinformatic analysis, we confirmed the important role of miR-340 as a pivotal regulator of breast cancer metastasis in targeting previo …
Suppressing the molecular signaling pathways involved in inflammation and cancer in breast cancer cell lines MDA-MB-231 and MCF-7 by miR-590.
Sheikholeslami A, Nabiuni M, Arefian E. Sheikholeslami A, et al. Tumour Biol. 2017 Apr;39(4):1010428317697570. doi: 10.1177/1010428317697570. Tumour Biol. 2017. PMID: 28443471 Free article.
The cell migration was tested by real-time quantitative reverse transcription polymerase chain reaction for MMP2/MMP9. The expression levels of miR-590 and the selected genes (i.e. JAK2, PI3K, MAPK1, and CREB) were measured 72 h after transfection. ...
The cell migration was tested by real-time quantitative reverse transcription polymerase chain reaction for MMP2/MMP9. The expression levels …
11 results