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Differences Between Plasma and Cerebrospinal Fluid Glial Fibrillary Acidic Protein Levels Across the Alzheimer Disease Continuum.
Benedet AL, Milà-Alomà M, Vrillon A, Ashton NJ, Pascoal TA, Lussier F, Karikari TK, Hourregue C, Cognat E, Dumurgier J, Stevenson J, Rahmouni N, Pallen V, Poltronetti NM, Salvadó G, Shekari M, Operto G, Gispert JD, Minguillon C, Fauria K, Kollmorgen G, Suridjan I, Zimmer ER, Zetterberg H, Molinuevo JL, Paquet C, Rosa-Neto P, Blennow K, Suárez-Calvet M; Translational Biomarkers in Aging and Dementia (TRIAD) study, Alzheimer’s and Families (ALFA) study, and BioCogBank Paris Lariboisière cohort. Benedet AL, et al. JAMA Neurol. 2021 Dec 1;78(12):1471-1483. doi: 10.1001/jamaneurol.2021.3671. JAMA Neurol. 2021. PMID: 34661615 Free PMC article.
Astrocyte biomarkers GFAP and YKL-40 mediate early Alzheimer's disease progression.
Pelkmans W, Shekari M, Brugulat-Serrat A, Sánchez-Benavides G, Minguillón C, Fauria K, Molinuevo JL, Grau-Rivera O, González Escalante A, Kollmorgen G, Carboni M, Ashton NJ, Zetterberg H, Blennow K, Suarez-Calvet M, Gispert JD; ALFA study. Pelkmans W, et al. Alzheimers Dement. 2024 Jan;20(1):483-493. doi: 10.1002/alz.13450. Epub 2023 Sep 10. Alzheimers Dement. 2024. PMID: 37690071 Free PMC article.
Quantification of [(18) F]florbetaben amyloid-PET imaging in a mixed memory clinic population: The ABIDE project.
Collij LE, Salvadó G, de Wilde A, Altomare D, Shekari M, Gispert JD, Bullich S, Stephens A, Barkhof F, Scheltens P, Bouwman F, van der Flier WM. Collij LE, et al. Alzheimers Dement. 2023 Jun;19(6):2397-2407. doi: 10.1002/alz.12886. Epub 2022 Dec 7. Alzheimers Dement. 2023. PMID: 36478646
INTRODUCTION: We investigated amyloid-burden quantification in a mixed memory clinic population. METHODS: [(18) F]Florbetaben amyloid-PET (positron emission tomography) scans of 348 patients were visually read and quantified using the Centiloid (CL) method. ...Linear mixed …
INTRODUCTION: We investigated amyloid-burden quantification in a mixed memory clinic population. METHODS: [(18) F]Florbetaben amyloid …
The amyloid imaging for the prevention of Alzheimer's disease consortium: A European collaboration with global impact.
Collij LE, Farrar G, Valléz García D, Bader I, Shekari M, Lorenzini L, Pemberton H, Altomare D, Pla S, Loor M, Markiewicz P, Yaqub M, Buckley C, Frisoni GB, Nordberg A, Payoux P, Stephens A, Gismondi R, Visser PJ, Ford L, Schmidt M, Birck C, Georges J, Mett A, Walker Z, Boada M, Drzezga A, Vandenberghe R, Hanseeuw B, Jessen F, Schöll M, Ritchie C, Lopes Alves I, Gispert JD, Barkhof F. Collij LE, et al. Front Neurol. 2023 Jan 20;13:1063598. doi: 10.3389/fneur.2022.1063598. eCollection 2022. Front Neurol. 2023. PMID: 36761917 Free PMC article. Review.
Approximately 1600 unique subjects with historical and prospective data were collected within this study. PET acquisition with [(18)F]flutemetamol or [(18)F]florbetaben radiotracers was performed and quantified using the Centiloid (CL) method. ...
Approximately 1600 unique subjects with historical and prospective data were collected within this study. PET acquisition with [(18)F …
Visual assessment of [(18)F]flutemetamol PET images can detect early amyloid pathology and grade its extent.
Collij LE, Salvadó G, Shekari M, Lopes Alves I, Reimand J, Wink AM, Zwan M, Niñerola-Baizán A, Perissinotti A, Scheltens P, Ikonomovic MD, Smith APL, Farrar G, Molinuevo JL, Barkhof F, Buckley CJ, van Berckel BNM, Gispert JD; ALFA study; AMYPAD consortium. Collij LE, et al. Eur J Nucl Med Mol Imaging. 2021 Jul;48(7):2169-2182. doi: 10.1007/s00259-020-05174-2. Epub 2021 Feb 22. Eur J Nucl Med Mol Imaging. 2021. PMID: 33615397 Free PMC article.
PURPOSE: To investigate the sensitivity of visual read (VR) to detect early amyloid pathology and the overall utility of regional VR. METHODS: [(18)F]Flutemetamol PET images of 497 subjects (ALFA+ N = 352; ADC N = 145) were included. ...Global and regional CL quantificatio …
PURPOSE: To investigate the sensitivity of visual read (VR) to detect early amyloid pathology and the overall utility of regional VR. METHOD …
APOE-ε4 modulates the association between regional amyloid deposition and cognitive performance in cognitively unimpaired middle-aged individuals.
Brugulat-Serrat A, Sánchez-Benavides G, Cacciaglia R, Salvadó G, Shekari M, Collij LE, Buckley C, van Berckel BNM, Perissinotti A, Niñerola-Baizán A, Milà-Alomà M, Vilor-Tejedor N, Operto G, Falcon C, Grau-Rivera O, Arenaza-Urquijo EM, Minguillón C, Fauria K, Molinuevo JL, Suárez-Calvet M, Gispert JD; ALFA Study. Brugulat-Serrat A, et al. EJNMMI Res. 2023 Mar 1;13(1):18. doi: 10.1186/s13550-023-00967-6. EJNMMI Res. 2023. PMID: 36856866 Free PMC article.
METHODS: The 352 CU participants (mean aged 61.1 [4.7] years) included completed two cognitive assessments (average interval 3.34 years), underwent [(18)F]flutemetamol Abeta positron emission tomography (PET), T1w magnetic resonance imaging (MRI), as well as APOE genotypin …
METHODS: The 352 CU participants (mean aged 61.1 [4.7] years) included completed two cognitive assessments (average interval 3.34 years), un …
A multisite analysis of the concordance between visual image interpretation and quantitative analysis of [(18)F]flutemetamol amyloid PET images.
Bucci M, Savitcheva I, Farrar G, Salvadó G, Collij L, Doré V, Gispert JD, Gunn R, Hanseeuw B, Hansson O, Shekari M, Lhommel R, Molinuevo JL, Rowe C, Sur C, Whittington A, Buckley C, Nordberg A. Bucci M, et al. Eur J Nucl Med Mol Imaging. 2021 Jul;48(7):2183-2199. doi: 10.1007/s00259-021-05311-5. Epub 2021 Apr 12. Eur J Nucl Med Mol Imaging. 2021. PMID: 33844055 Free PMC article.
BACKGROUND: [(18)F]flutemetamol PET scanning provides information on brain amyloid load and has been approved for routine clinical use based upon visual interpretation as either negative (equating to none or sparse amyloid plaques) or amyloid positive (equating to moderate …
BACKGROUND: [(18)F]flutemetamol PET scanning provides information on brain amyloid load and has been approved for routine clinical us …
The mediating role of neuroimaging-derived biological brain age in the association between risk factors for dementia and cognitive decline in middle-aged and older individuals without cognitive impairment: a cohort study.
Cumplido-Mayoral I, Brugulat-Serrat A, Sánchez-Benavides G, González-Escalante A, Anastasi F, Milà-Alomà M, López-Martos D, Akinci M, Falcón C, Shekari M, Cacciaglia R, Arenaza-Urquijo EM, Minguillón C, Fauria K, Molinuevo JL, Suárez-Calvet M, Grau-Rivera O, Vilaplana V, Gispert JD; ALFA study. Cumplido-Mayoral I, et al. Lancet Healthy Longev. 2024 Apr;5(4):e276-e286. doi: 10.1016/S2666-7568(24)00025-4. Lancet Healthy Longev. 2024. PMID: 38555920 Free article.
20 results