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Irvalec inserts into the plasma membrane causing rapid loss of integrity and necrotic cell death in tumor cells.
Molina-Guijarro JM, Macías Á, García C, Muñoz E, García-Fernández LF, David M, Núñez L, Martínez-Leal JF, Moneo V, Cuevas C, Lillo MP, Villalobos Jorge C, Valenzuela C, Galmarini CM. Molina-Guijarro JM, et al. Among authors: valenzuela c. PLoS One. 2011 Apr 27;6(4):e19042. doi: 10.1371/journal.pone.0019042. PLoS One. 2011. PMID: 21556352 Free PMC article.
Elisidepsin Interacts Directly with Glycosylceramides in the Plasma Membrane of Tumor Cells to Induce Necrotic Cell Death.
Molina-Guijarro JM, García C, Macías Á, García-Fernández LF, Moreno C, Reyes F, Martínez-Leal JF, Fernández R, Martínez V, Valenzuela C, Lillo MP, Galmarini CM. Molina-Guijarro JM, et al. Among authors: valenzuela c. PLoS One. 2015 Oct 16;10(10):e0140782. doi: 10.1371/journal.pone.0140782. eCollection 2015. PLoS One. 2015. PMID: 26474061 Free PMC article.