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89 results

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Hypoxic Modulation of HLA-G Expression through the Metabolic Sensor HIF-1 in Human Cancer Cells.
Garziera M, Scarabel L, Toffoli G. Garziera M, et al. J Immunol Res. 2017;2017:4587520. doi: 10.1155/2017/4587520. Epub 2017 Jul 11. J Immunol Res. 2017. PMID: 28781970 Free PMC article. Review.
The human leukocyte antigen-G (HLA-G) is considered an immune checkpoint molecule involved in tumor immune evasion. ...Under hypoxia, HLA-G-negative cell lines might transcribe HLA-G without translation of the protein while in contrast, HLA-G-po …
The human leukocyte antigen-G (HLA-G) is considered an immune checkpoint molecule involved in tumor immune evasion. ...Under h …
Association of HLA-G 3'UTR Polymorphisms with Response to First-Line FOLFIRI Treatment in Metastatic Colorectal Cancer.
Scarabel L, Polesel J, De Mattia E, Buonadonna A, D'Andrea MR, Cecchin E, Toffoli G. Scarabel L, et al. Pharmaceutics. 2022 Dec 7;14(12):2737. doi: 10.3390/pharmaceutics14122737. Pharmaceutics. 2022. PMID: 36559230 Free PMC article.
Microenvironmental factors such as non-classical human leukocyte antigen-G (HLA-G) have been associated with cancer invasiveness and metastatic progression. HLA-G expression has been associated with specific single-nucleotide polymorphisms (SNP) in HLA-G …
Microenvironmental factors such as non-classical human leukocyte antigen-G (HLA-G) have been associated with cancer invasivene …
Fluorescent Carbon Nanoparticles in Medicine for Cancer Therapy: An Update.
Rani R, Kumar V, Rizzolio F. Rani R, et al. ACS Med Chem Lett. 2017 Dec 28;9(1):4-5. doi: 10.1021/acsmedchemlett.7b00523. eCollection 2018 Jan 11. ACS Med Chem Lett. 2017. PMID: 29348802 Free PMC article.
In the past few years since our viewpoint on carbon nanoparticles was first published in 2013 (Kumar, V.; Toffoli, G.; Rizzolio, F. ACS Med. Chem. Lett.2013, 4 (11), 1012-1013), a considerable progress has been made in the area of synthesis, functionalization, and a …
In the past few years since our viewpoint on carbon nanoparticles was first published in 2013 (Kumar, V.; Toffoli, G.; Rizzoli …
Ambroxol for the Treatment of Patients With Parkinson Disease With and Without Glucocerebrosidase Gene Mutations: A Nonrandomized, Noncontrolled Trial.
Mullin S, Smith L, Lee K, D'Souza G, Woodgate P, Elflein J, Hällqvist J, Toffoli M, Streeter A, Hosking J, Heywood WE, Khengar R, Campbell P, Hehir J, Cable S, Mills K, Zetterberg H, Limousin P, Libri V, Foltynie T, Schapira AHV. Mullin S, et al. JAMA Neurol. 2020 Apr 1;77(4):427-434. doi: 10.1001/jamaneurol.2019.4611. JAMA Neurol. 2020. PMID: 31930374 Free PMC article. Clinical Trial.
OBJECTIVE: To assess safety, tolerability, cerebrospinal fluid (CSF) penetration, and target engagement of ambroxol therapy with GCase in patients with PD with and without GBA1 mutations. INTERVENTIONS: An escalating dose of oral ambroxol to 1.26 g per day. DESIGN, SETTING …
OBJECTIVE: To assess safety, tolerability, cerebrospinal fluid (CSF) penetration, and target engagement of ambroxol therapy with GCase in pa …
Generalized Toffoli Gate Decomposition Using Ququints: Towards Realizing Grover's Algorithm with Qudits.
Nikolaeva AS, Kiktenko EO, Fedorov AK. Nikolaeva AS, et al. Entropy (Basel). 2023 Feb 20;25(2):387. doi: 10.3390/e25020387. Entropy (Basel). 2023. PMID: 36832752 Free PMC article.
In this work, we present an efficient decomposition of the generalized Toffoli gate on five-level quantum systems-so-called ququints-that use ququints' space as the space of two qubits with a joint ancillary state. The basic two-qubit operation we use is a version of the c …
In this work, we present an efficient decomposition of the generalized Toffoli gate on five-level quantum systems-so-called ququints- …
Cisplatin resistance can be curtailed by blunting Bnip3-mediated mitochondrial autophagy.
Vianello C, Cocetta V, Catanzaro D, Dorn GW 2nd, De Milito A, Rizzolio F, Canzonieri V, Cecchin E, Roncato R, Toffoli G, Quagliariello V, Di Mauro A, Losito S, Maurea N, Scaffa C, Sales G, Scorrano L, Giacomello M, Montopoli M. Vianello C, et al. Cell Death Dis. 2022 Apr 22;13(4):398. doi: 10.1038/s41419-022-04741-9. Cell Death Dis. 2022. PMID: 35459212 Free PMC article.
HLA-G 3'UTR Polymorphisms Impact the Prognosis of Stage II-III CRC Patients in Fluoropyrimidine-Based Treatment.
Garziera M, Bidoli E, Cecchin E, Mini E, Nobili S, Lonardi S, Buonadonna A, Errante D, Pella N, D'Andrea M, De Marchi F, De Paoli A, Zanusso C, De Mattia E, Tassi R, Toffoli G. Garziera M, et al. PLoS One. 2015 Dec 3;10(12):e0144000. doi: 10.1371/journal.pone.0144000. eCollection 2015. PLoS One. 2015. PMID: 26633805 Free PMC article.
Soluble HLA-G has been associated to 3'UTR +2960 Ins/Ins and +3035 C/T (lower levels) and +3187 G/G (high levels) genotypes. ...Our study shows a prognostic and independent role of 3 HLA-G 3'UTR SNPs, +2960 14-bp INDEL, +3035 C>T, and +3187 A> …
Soluble HLA-G has been associated to 3'UTR +2960 Ins/Ins and +3035 C/T (lower levels) and +3187 G/G (high levels) genot …
Soluble HLA-G expression levels and HLA-G/irinotecan association in metastatic colorectal cancer treated with irinotecan-based strategy.
Scarabel L, Garziera M, Fortuna S, Asaro F, Toffoli G, Geremia S. Scarabel L, et al. Sci Rep. 2020 May 29;10(1):8773. doi: 10.1038/s41598-020-65424-z. Sci Rep. 2020. PMID: 32471996 Free PMC article.
We here explore the soluble Human Leukocyte Antigen-G (sHLA-G) expression level as clinical biomarker in metastatic colorectal cancer (mCRC). ...The results suggest a link between HLA-G levels and irinotecan (CPT-11) pharmacokinetic, leading to hypothesize a …
We here explore the soluble Human Leukocyte Antigen-G (sHLA-G) expression level as clinical biomarker in metastatic colorectal …
Inhibition of host immune response in colorectal cancer: human leukocyte antigen-G and beyond.
Garziera M, Toffoli G. Garziera M, et al. World J Gastroenterol. 2014 Apr 14;20(14):3778-94. doi: 10.3748/wjg.v20.i14.3778. World J Gastroenterol. 2014. PMID: 24744572 Free PMC article. Review.
Their type, density and location are summarized in the Immune Score that has been shown to improve prognostic prediction of CRC patients. The non-classical MHC class I human leukocyte antigen-G (HLA-G), is a crucial tumor-driven immune escape molecule involved in im …
Their type, density and location are summarized in the Immune Score that has been shown to improve prognostic prediction of CRC patients. Th …
89 results