Downregulation of IRF8 in alveolar macrophages by G-CSF promotes metastatic tumor progression.
Tzetzo SL, Kramer ED, Mohammadpour H, Kim M, Rosario SR, Yu H, Dolan MR, Oturkar CC, Morreale BG, Bogner PN, Stablewski AB, Benavides FJ, Brackett CM, Ebos JML, Das GM, Opyrchal M, Nemeth MJ, Evans SS, Abrams SI.
Tzetzo SL, et al.
iScience. 2024 Feb 10;27(3):109187. doi: 10.1016/j.isci.2024.109187. eCollection 2024 Mar 15.
iScience. 2024.
PMID: 38420590
Free PMC article.
Translational relevance of IRF8 downregulation was observed among macrophage precursors in breast cancer and a CD68(hi)IRF8(lo)G-CSF(hi) gene signature suggests poorer prognosis in triple-negative breast cancer (TNBC), a G-CSF-expressing subtype. ...AMs are an attra …
Translational relevance of IRF8 downregulation was observed among macrophage precursors in breast cancer and a CD68(hi)IRF8(lo)G-CSF( …